Oxidative degradation of a sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrone in aqueous/organic cosolvent mixtures

Pharmaceutical Research

Volumn 19, Issue 4, 2002, Pages 538-545

  Hovorka, S W ^a   Hageman, M J ^b   Schoneich C ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b PFIZER INC   (United States)

Author keywords

5,6 dihydro 4 hydroxy 2 pyrone; Hydroxylation; Oxidation; Payne oxidation; Peroxycarboximidic acid; Stability

Indexed keywords

5,6 DIHYDRO 4 HYDROXY 2 PYRONE; HYDROGEN PEROXIDE; N [3 [1 (4 HYDROXY 2 OXO 6 PHENYL 6 PROPYLTETRAHYDRO 2H PYRAN 3 YL)PROPYL]PHENYL] 5 (TRIFLUOROMETHYL) 2 PYRIDINYLSULFONAMIDE; ORGANIC SOLVENT; PEROXIDE; PEROXY RADICAL; PYRONE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; ATOMIC EMISSION SPECTROMETRY; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

ORGANIC CHEMICALS; OXIDATION-REDUCTION; SOLUTIONS; SOLVENTS; SULFONAMIDES; WATER;

EID: 0036109132     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015116317269     Document Type: Article

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