Non-peptidic HIV protease inhibitors: C2-symmetry-based design of bis- sulfonamide dihydropyrones

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 10, 1998, Pages 1237-1242

  Janakiraman, Musiri N ^a   Watenpaugh, Keith D ^a   Tomich, Paul K ^a   Chong, Kong Teck ^a   Turner, Steve R ^a   Tommasi, Ruben A ^a   Thaisrivongs, Suvit ^a   Strohbach, Joseph W ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRONE SULFONAMIDE; PROTEINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; X RAY CRYSTALLOGRAPHY;

DIMERIZATION; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0032546525     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00197-8     Document Type: Article

References (9)

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6. 1 = 699.1695, found 699.1679.
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8. 7. The biological assay used to measure in vitro inhibition of the HIV-1 protease has been previously described in reference 2.
9. 8. The biological assay used to measure whole cell antiviral activity has been previously described: Chong, K.-T; Pagano, P. J.; Hinshaw, R. R. Antimicrob. Agents Chemother. 1994, 38, 288.