Relb-p50 NF-κB complexes are selectively induced by cytomegalovirus immediate-early protein 1: Differential regulation of Bcl-xL promoter activity by NF-κB family members

Journal of Virology

Volumn 76, Issue 11, 2002, Pages 5737-5747

  Jiang, H Y ^a   Petrovas, Constantinos ^a   Sonenshein, Gail E ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYC PROTEIN; PROTEIN BCL XL; PROTEIN P50; TRANSCRIPTION FACTOR RELB; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; CYTOMEGALOVIRUS; EMBRYO; FIBROBLAST; GENE ACTIVATION; GENE ACTIVITY; GENE CONTROL; GENE INDUCTION; GENE TARGETING; IMMUNOFLUORESCENCE; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SMOOTH MUSCLE FIBER; STEADY STATE; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

3T3 CELLS; ANIMALS; BCL-X PROTEIN; CATTLE; CELL NUCLEUS; CELLS, CULTURED; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CYTOMEGALOVIRUS; FEMALE; GENES, REPORTER; HUMANS; IMMEDIATE-EARLY PROTEINS; MICE; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS; VIRAL PROTEINS;

EID: 0036098494     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.11.5737-5747.2002     Document Type: Article

References (65)

1. Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes
2. Nuclear factor-κB/Rel blocks transforming growth factor beta1-induced apoptosis of murine hepatocyte cell lines
3. TGF beta 1 inhibits NF-κB/Rel activity inducing apoptosis of B cells: Transcriptional activation of IκBα
4. The inducible transcription activator NF-κB: Regulation by distinct protein subunits
5. Control of apoptosis by Rel/NF-κB transcription factors
6. Physical interactions between Ets and NF-κB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells
7. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
8. Cell density and estradiol modulation of procollagen type III in cultured calf smooth muscle cells
9. Inhibition of NF-κB activity induces apoptosis in murine hepatocytes
10. NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats
11. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
12. Expression of the c-myb proto-oncogene in bovine vascular smooth muscle cells
13. Expression of relB transcripts during lymphoid organ development: Specific expression in dendritic antigen-presenting cells
14. The Rel/NF-κB family directly activates expression of the apoptosis inhibitor Bcl-xL
15. Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element
16. Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-κB, and DNA by a designed DNA-binding ligand
17. Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response
18. Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity
19. The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus
20. Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter
21. Transactivation of transcription by herpes virus products: Requirement for two HSV-1 immediate-early polypeptides for maximum activity
22. Trans activation of plasmid-borne promoters by adenovirus and several herpes group viruses
23. Physical interaction of the bHLH LYLI protein and NF-κB1 p105
24. Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal
25. Identification and characterization of nuclear factor κB binding sites in the murine bcl-x promoter
26. NF-kappa B and Rel: Participants in a multiform transcriptional regulatory system
27. The inducible transcription factor NF-kappa B: Structure-function relationship of its protein subunits
28. Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA
29. Human cytomegalovirus late protein encoded by ie2: A trans-activator as well as a repressor of gene expression
30. Negative interaction between the RelA (p65) subunit of NF-κB and the progesterone receptor
31. The DNA binding subunit of NF-κB is identical to factor KBFI and homologous to the rel oncogene product
32. The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells
33. Localization of c-Myb and induction of apoptosis by antisense oligonucleotide c-Myb after angioplasty of porcine coronary arteries
34. Differential regulation of the c-myc oncogene promoter by the NF-κB rel family of transcription factors
35. Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line
36. Antisense strategies to inhibit restenosis
37. Cytomegalovirus infection enhances smooth muscle cell proliferation and intimal thickening of rat aortic allografts
38. Distinct NF-kappa B/Rel transcription factors are responsible for tissue-specific and inducible gene activation
39. Adenovirus-mediated expression of a ribozyme to c-myb mRNA inhibits smooth muscle cell proliferation and neo-intima formation in vivo
40. 1-to-S phase transition and cooperates with c-myc to mediate progression to S phase
41. Human cytomegalovirus in a SCID-hu mouse: Thymic epithelial cells are prominent targets of viral replication
42. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFκB
43. Human T-Cell lymphotropic virus type 1 tax represses c-Myb-dependent transcription through activation of the NF-κB pathway and modulation of coactivator usage
44. Transcriptional regulation of human polyomavirus JC: Evidence for a functional interaction between RelA (p65) and the Y-box-binding protein, YB-1
45. Aberrant rel/NF-κB genes and activity in human cancer
46. 1 phase of the cell cycle
47. Contribution of NF-κB and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: Distinct patterns of viral growth are determined by T-cell types
48. Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-κB
49. RelB, a new Rel family transcription activator that can interact with p50-NF-κB
50. NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation
51. Maintenance of nuclear factor-kappa B/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins
52. Tissue-selective expression of dominant-negative proteins for the regulation of vascular smooth muscle cell proliferation
53. Ret/NF-kappa B transcription factors and the control of apoptosis
54. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer
55. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB
56. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration
57. Transcriptional elongation of c-myb is regulated by NF-κB (p50/RelB)
58. cAMP-induced NF-κB (p50/reiB) binding to a c-myb intronic enhancer correlates with c-myb up-regulation and inhibition of erythroleukemia cell differentiation
59. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
60. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family
61. -/- double-knockout mice
62. NF-kappa B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells
63. Inhibition of NF-κB/Rel induces apoptosis of murine B cells
64. Human cytomegalovirus upregulates NF-κB activity by transactivating the NF-κB p105/p50 and p65 promoters
65. Induction of the transcription factor Spl during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-κB promoters