Orf virus immuno-modulation and the host immune response

Veterinary Immunology and Immunopathology

Volumn 87, Issue 3-4, 2002, Pages 395-399

  Haig, David M ^a   Thomson, Jackie ^a   McInnes, Colin ^a   McCaughan, Catherine ^b   Imlach, Wendy ^b   Mercer, Andrew ^b   Fleming, Stephen ^b  

^a MOREDUN RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Interleukin 10; Poxvirus; Sheep

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; PROTEIN GIF; PROTEIN OVIFNR; UNCLASSIFIED DRUG; VASCULOTROPIN; VIRUS PROTEIN;

CELL ACTIVATION; CONFERENCE PAPER; CYTOKINE PRODUCTION; EPIDERMIS CELL; GENE FUNCTION; GENETIC CODE; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATION; KERATINOCYTE; MACROPHAGE ACTIVATION; NONHUMAN; PATHOGENICITY; POXVIRUS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; VIRUS CELL INTERACTION; VIRUS IMMUNITY; VIRUS REPLICATION;

ANIMALS; ECTHYMA, CONTAGIOUS; ENDOTHELIAL GROWTH FACTORS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-10; INTERLEUKIN-2; LYMPHOKINES; POXVIRIDAE; SHEEP; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VIRAL PROTEINS;

ORF VIRUS; OVIS ARIES; POXVIRIDAE;

EID: 0036088313     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(02)00087-9     Document Type: Conference Paper

References (24)

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2. Detection of cellular cytokine mRNA expression during orf virus infection in sheep: Differential IFN-γ mRNA expression by cells in primary versus reinfection skin lesions
3. Effect of passively-acquired antibodies and vaccination on the immune response to contagious ecthyma virus
4. Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2
5. A single amino acid determines the immunostimulatory activity of interleukin-10
6. A homolog of interleukin-10 is encoded by the poxvirus orf virus
7. Sequence and functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus orf virus
8. Identification of functional domains on human interleukin-10
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10. The effect of intradermal injection of GM-CSF and TNF-α on the accumulation of dendritic cells in ovine skin
11. The survival and growth of ovine afferent lymph dendritic cells in culture depends on tumour necrosis factor-α and is enhanced by granulocyte-macrophage colony-stimulating factor but inhibited by interferon-γ
12. The cytokine response of afferent lymph following orf virus reinfection of sheep
13. Cyclosporin-A abrogates the acquired immunity to cutaneous reinfection with the parapoxvirus orf virus
14. + T cells during orf virus reinfection
15. The orf virus OV20.0L gene product is involved in interferon resistance and inhibits an interferon-inducible, dsRNA-dependent kinase
16. Changes in the MHC class II dendritic cell population of ovine skin in response to orf virus infection
17. The B and T cell responses to orf virus infection of ovine skin
18. Phenotypic characterisation of the dendritic cells accumulating in ovine dermis following primary and secondary orf virus infections
19. + T cells and a humoral immune response are necessary for the elimination of orf virus from the skin of sheep
20. Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus
21. Orf virus encodes a homolog of the vaccinia virus interferon-resistance gene E3L
22. Viral vascular endothelial growth factor plays a critical role in orf virus infection
23. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR-2 and neuropilin-1