Aberrant expression of centractin and capping proteins, integral constituents of the dynactin complex, in fetal down syndrome brain

Biochemical and Biophysical Research Communications

Volumn 291, Issue 1, 2002, Pages 62-67

  Gulesserian, Talin ^a   Hwan Kim, Seong ^a   Fountoulakis, Michael ^b   Lubec, Gert ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Axonal transport; Capping protein; Centractin; Cytoskeleton; Down syndrome; Dynactin complex

Indexed keywords

BRAIN PROTEIN; CENTRACTIN ALPHA; CYTOSKELETON PROTEIN; DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; F ACTIN CAPPING PROTEIN ALPHA 1; F ACTIN CAPPING PROTEIN ALPHA 2; F ACTIN CAPPING PROTEIN BETA; KINESIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BRAIN CORTEX; CELL FUNCTION; CELL MOTILITY; CELL NUCLEUS; CELL ORGANELLE; CLINICAL ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; CYTOSKELETON; DOWN SYNDROME; FEMALE; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; MALE; MASS SPECTROMETRY; MITOSIS; NERVE FIBER TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; TWO DIMENSIONAL ELECTROPHORESIS;

EID: 0036086620     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6389     Document Type: Article

References (43)

1. Microtubule dynamics: Tread milling comes around again
2. Kinesin and dynein superfamily proteins and the mechanism of organelle transport
3. Cytoskeletal proteins and Golgi dynamics
4. Retrograde transport of macromolecules in axons
5. The role of dynein in retrograde axonal transport
6. Two activators of microtubule-based vesicle transport
7. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein
8. The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport
9. Centractin (ARP1) associated with spectrin revealing a potential mechanism to link dynactin to intracellular organelles
10. Cytoplasmic dynein and dynactin are required for the transport of microtubules into the axon
11. Glued participates in distinct microtubule-based activities in Drosophila eye development
12. Mutant molecular motors disrupt neural circuits in Drosophila
13. The role of the dynactin complex in intracellular mobility
14. Dynactin
15. Ultrastructural analysis of the dynactin complex: An actin-related protein is a component of a filament that resembles F-actin
16. Glued and a novel actin
17. Actin-related protein nomenclature and classification
18. Centractin is an actin homologue associated with the centrosome
19. Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin
20. Golgi spectrin: Identification of an erythroid beta-spectrin homolog associated with the Golgi complex
21. CapZ(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle
22. Purification and initial characterization of a protein from skeletal muscle that caps the barbed ends of actin filaments
23. Effects of CapZ, an actin capping protein of muscle, on the polymerization of actin
24. Regulation of CapZ, an actin capping protein of chicken muscle, by anionic phospholipids
25. Huntingtin-associated protein I (HAP I) interacts with the p150 Glued subunit of dynactin
26. Interaction of huntingtin-associated protein with dynactin p150 Glued
27. Effect of Alzheimer's brain extracts on dynein immunoreactivity in PC12 cells
28. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
29. Effect of protein application mode and acrylamide concentration on the resolution of protein spots separated by two-dimensional gel electrophoresis
30. Identification of protein by matrix-assisted laser desorption ionization-mass spectrometry following in-gel digestion in low-salt, nonvolatile buffer and simplified peptide recovery
31. Reliable automatic protein identification from matrix-assisted laser desorption/ionization mass spectrometric peptide fingerprints
32. Two-dimensional map of human brain proteins
33. Dynein is the motor of retrograde axonal transport of organelles
34. Cytoplasmic dynein is a minus end-directed motor for membraneous organelles
35. Brain dynein (MAP1C) localizes on both antero-gradely and retrogradely transported membranous organelles in vivo
36. Molecular mechanisms regulating the retrograde axonal transport of neurotrophins
37. Sequence of centromere separation another mechanism for origin of nondisjunction
38. Spindle microtubular dysfunction in mothers of Down syndrome children
39. Cytoplasmic microtubule-associated motors
40. Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure
41. Manifold reduction of moesin in fetal down syndrome brain
42. Deterioration of the transcriptional, splicing and elongation machinery in brain of fetal Down syndrome
43. Decreased transcription factor junD in brains of patients with Down syndrome