T cell receptor δ repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 282, Issue 6 45-6, 2002, Pages

  Holtmeier, Wolfgang ^a   Hennemann, Andreas ^a   May, Ekkehard ^b   Duchmann, Rainer ^c   Caspary, Wolfgang F ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Crohn's disease; Gamma delta mucosal immunology; Ulcerative colitis

Indexed keywords

RNA; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; AUTOIMMUNE DISEASE; COLON MUCOSA; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MUCOSAL IMMUNITY; NUCLEOTIDE SEQUENCE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; ULCERATIVE COLITIS;

EID: 0036086508     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00224.2001     Document Type: Article

References (53)

1. Localization of γ/δ T cells to the intestinal epithelium is independent of normal microbial colonization
2. Tolerance of T cell receptor γ/δ cells in the intestine
3. Modulation of epithelial cell growth by intraepithelial γ/δ T cells
4. Non-random expression of T cell receptor γ and δ variable gene segments in functional T lymphocyte clones from human peripheral blood
5. Immune mechanisms in chronic inflammatory bowel disease
6. Analysis of γ/δ V region usage in normal and diseased human intestinal biopsies and peripheral blood by polymerase chain reaction (PCR) and flow cytometry
7. Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease
8. Recognition by γ/δ T cells
9. A common TCR β-chain expressed by CD8+ intestinal mucosa T cells in ulcerative colitis
10. The Vδ 1 T cell receptor repertoire in human small intestine and colon
11. Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis
12. Expression of T cell receptors α/β and γ/δ in the ileal mucosa of patients with Crohn's disease and with spondylarthropathy
13. A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the Vδ 1 gene segment
14. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
15. Experimental models of inflammatory bowel disease
16. Attributes of γ/δ intraepithelial lymphocytes as suggested by their transcriptional profile
17. Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease
18. + T cells provide B cell help
19. Immunohistochemical characterization, distribution, and ultrastructure of lymphocytes bearing T-cell receptor γ/δ in inflammatory bowel disease
20. Increase of circulating γ/δ T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease
21. Molecular evidence for two forms of Crohn's disease
22. Recognition of stress-induced MHC molecules by intestinal epithelial γ/δ T cells
23. Selective expansion of specific T cell receptors in the inflamed colon of Crohn's disease
24. Activation and control of self-reactive γ/δ T cells
25. γ/δ cells: A right time and a right place for a conserved third way of protection
26. γ/δ cells regulate autoimmunity
27. Role of T lymphocytes in rat 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis: Increased mortality after γ/δ T cell depletion and no effect of α/β T cell depletion
28. The δ T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage
29. IgA and IgM VH repertoires in human colon: Evidence for clonally expanded B cells that are widely disseminated
30. The TCR δ repertoire in normal human skin is restricted and distinct from the TCR δ repertoire in the peripheral blood
31. The TCR-δ repertoire in human intestine undergoes characteristic changes during fetal to adult development
32. γ/δ T cell receptor repertoire in brain lesions of patients with multiple sclerosis
33. Current concepts in mucosal immunity. III. Ontogeny and function of γ/δ T cells in the intestine
34. + γ/δ T-cell clonotypes in intestinal mucosa from patients with Crohn's disease
35. Over-utilization of the Jδ3 gene-segment in Crohn's disease
36. Systemic activation and antigen-driven oligoclonal expansion of T cells in a mouse model of colitis
37. Changes in human mucosal γ/δ T cell repertoire and function associated with the disease process in inflammatory bowel disease
38. Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCR-α mutant mice with inflammatory bowel disease
39. Specific clonal T cell accumulation in intestinal lesions of Crohn's disease
40. Repertoire analysis of human peripheral blood lymphocytes using a human Vδ3 region-specific monoclonal antibody. Characterization of dual T cell receptor (TCR) δ-chain expressors and α/δ T cells expressing Vδ3J αCα-encoded TCR chains
41. T cells in inflammatory bowel disease: Protective and pathogenic roles
42. 4+ T cells
43. Analysis of function, specificity and T cell receptor expression of cloned mucosal T cell lines in Crohn's disease
44. 4+ lymphocytes in chronic inflammatory bowel disease
45. CDR3 length in antigen-specific immune receptors
46. T cells and cytokines in Crohn's disease
47. Keratinocyte growth factor and coeliac disease
48. Evidence of T cell receptor β-chain patterns in inflammatory and noninflammatory bowel disease states
49. Evidence for an altered T-cell receptor repertoire in Crohn's disease
50. Clonal expansions of activated γ/δ T cells in recent-onset multiple sclerosis
51. Increased frequency of abnormal γ/δ T cells in blood of patients with inflammatory bowel diseases
52. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry
53. γ/δ T cell receptor-positive cells of the human gastrointestinal mucosa: Occurrence and V region gene expression in Heliobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease