Role of antigen-presenting cells in cross-priming of cytotoxic T lymphocytes by apoptotic cells

Journal of Leukocyte Biology

Volumn 66, Issue 2, 1999, Pages 247-251

  Ronchetti, Anna ^a   Iezzi, Giandomenica ^a   Crosti, Maria Cristina ^a   Garancini, Maria Paola ^a   Protti, Maria Pia ^a   Bellone, Matteo ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Apoptosis; Cancer immunity; In vivo animal models; Ovalbumin; RMA

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; TUMOR ANTIGEN;

ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CYTOTOXIC T LYMPHOCYTE; IMMUNOGENICITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY;

ANIMALIA;

EID: 0032796387     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.66.2.247     Document Type: Article

References (35)

1. Choen, J. J. (1993) Apoptosis. Immunol. Today 14, 126-130.
2. Ren, Y., Savill, J. (1998) Apoptosis: the importance of being eaten. Cell Death Diff. 5, 563-568.
3. Vaishnaw, A. K., McNally, J. C., Elkon, K. B. (1997) Apoptosis and rheumatic diseases. Arthr. Rheum. 40, 1917-1927.
4. Utz, P. J., Anderson, P. (1998) Posttranslational protein modifications, apoptosis, and the bypass of toleiance to autoantigens. Arthr. Rheum. 41, 1152-1160.
5. Bell, D. A., Morrison, B. (1991) The spontaneous apoptotic death of normal human lymphocytes in vitro: the release of an immunoproliferative response to nucleosome in vitro. Clin. Immunol. Immunopathol. 60, 13-26.
6. Casciola-Rosen, L. A., Anhalt, G., Rosen, A. (1994) Autoantigens targeted in systemic lupus erythematosus ere clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179, 1317-1330.
7. Casciola-Rosen, L. A., Anhalt, G., Rosen, A. (1995) DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med. 182, 1625-1634.
8. Albert, M. L., Sauter, B., Bhardwaj, N. (1998) Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTL. Nature 392, 86-89.
9. Banchereau, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
10. Germain, R. N., Margulies, D. H. (1993) The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11, 403-450.
11. Germain, R. N., Castellino, F., Ricai, H., Reis e Sousa, C., Romagnoli, P., Sadegh-Nasseri, S., Zhong, G-M. (1996) Processing and presentation of endocytically acquired protein antigens by MHC class II and I molecules. Immunol. Rev. 151, 5-30.
12. Bevan, M. J. (1976) Cross-priming for secondary cytotoxic responce to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J. Exp. Med. 143, 1283-1288.
13. Bevan, M. J. (1995) Antigen presentation to cytotoxic T lymphocytes in vivo. J. Exp. Med. 182, 639-641.
14. Karre, K., Ljunggren, H-G., Piontek, G., Kiessling, R. (1986) H-2 deficient lymphoma variants suggests alternative immune defence strategy. Nature 319, 675-678.
15. Iezzi, G., Rivolta L., Ronchetti, A., Martin-Fontecha, A., Rosato, A., Protti, M. P., Sabbadini, M. G., Bellone, M. (1997) The immunogenicity of experimental tumors is strongly biased by the expression of dominant viral cytotoxic T lymphocyte epitopes. Cancer Res. 57, 2564-2568.
16. Bellone, M., Iezzi, G., Rovere, P., Galati, G., Ronchetti, A., Protti, M. P., Davoust, J., Rugarli, C., Manfredi, A. A. (1997) Processing of engulfed apoptotic cells yields T cells epitopes. J. Immunol. 159, 5391-5399.
17. Chen, L., McGowan, P., Ashe, S., Johnston, J., Ii, Y., Hellstrom, I., Hellstrom, K. E. (1994) Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity. J. Exp. Med. 179, 523-532.
18. Martin-Fontecha, A., Cavallo, F., Bellone, M., Heltai, S., Iezzi, G., Tornaghi, P., Nabavi, N., Forni, G., Dellabona, P., Casorati, G. (1996) Heterogeneous effects of B7-1 and B7-2 in the induction of both protective and therapeutic anti-tumor immunity against different mouse tumors. Eur. J. Immunol. 26, 1851-1859.
19. Rotzschke, O., Falk, K., Stevanovic, S., Jung, G., Walden, P., Rammensee, H. G. (1991) Exact prediction of a natural T cell epitope. Eur. J. Immunol. 21, 2891-2894.
20. Celik, C. D., Lewis, D. A., Goldrosen, M. H. (1983) Demonstration of immunogenicity with the poorly immunogenic B16 melanoma. Cancer Res. 43, 3507-3510.
21. Savill, J. S., Fadok, V., Henson, P., Haslett, C. (1993) Phagocyte recognition of cells undergoing apoptosis. Immunol. Today 14, 131-136.
22. Bellingan, G. J. H., Caldwell, S. E. M., Howei, I., Dransfield, Haslett, C. (1996) In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally but migrate to the draining lymph nodes, J. Immunol. 157, 2577-2585.
23. Iezzi, G., Protti, M. P., Rugarli, C., Bellone, M. (1996) B7.1 expression on tumor cells circumvent the need for antigen presentation for in vitro propagation of cytotoxic T cell lines. Cancer Res. 56, 11-15.
24. Reis e Sousa, C., Germain, R. N. (1995) Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis. J. Exp. Med. 182, 841-851.
25. Ronchetti, A., Rovere, P., Iezzi, G., Galati, G., Heltai, S., Protti, M. P., Garancini, M. P., Manfredi, A. A., Rugarli, C., Bellone, M. (1999) Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen presenting cells, and cytokines. J. Immunol., in press.
26. Bellone, M., Iezzi, G., Martin-Fontecha, A., Rivolta, L., Manfredi, A. A., Protti, M. P., Freschi, M., Dellabona, P., Casorali, G., Rugarli, C. (1997) Rejection of nonimmunogenic melanoma by vaccination with natural melanoma peptides on engineered antigen-presenting cells. J. Immunol. 158, 783-789.
27. Lenshow, D. J., Walunas, T. L., Bluestone, J. A. (1996) CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14, 233-258.
28. Voll, R. E., Hermann, M., Roth, E. A., Stach, C, Salden, J. R., Girkontaite, I. (1997) Immunosoppressive effects of apoptotic cells. Nature 390, 350-351.
29. 2, and PAF. J. Clin. Invest. 101, 890-898.
30. 3 integrin and requires untracellular and extracellular calcium. Eur. J. Immunol. 27, 1893-1900.
31. Rovere, P., Zimmermann, V. S., Forquet, F., Demandolx, D., Trucy, J., Ricciardi-Castagnoli, P., Davoust, J. (1998) Dendritic cell maturation and antigen presentation in the absence of invariant chain. Proc. Natl. Acad. Sci. USA 95, 1067-1072.
32. Botto, M., Dell'Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., Walport, M. J. (1998) Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nature Genetics 19, 56-61.
33. Tan, E. M. (1994) Autoimmunity and apoptosis. J. Exp. Med. 179, 1083-1086.
34. French, L. E., Tschopp, J. (1997) Thyroiditis and hepatitis: Fas on the road to disease. Nature Med. 3, 387-388.
35. Carrol, M. C. (1998) The lupus paradox. Nature Genetics 19, 3-4.