4'-Hydroxy aceclofenac suppresses the interleukin-1-induced production of promatrix metalloproteinases and release of sulfated-glycosaminoglycans from rabbit articular chondrocytes

European Journal of Pharmacology

Volumn 401, Issue 3, 2000, Pages 429-436

  Akimoto, Hiroshi ^a   Yamazaki, Ryuta ^b   Hashimoto, Shusuke ^b   Sato, Takashi ^a   Ito, Akira ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

4' Hydroxy aceclofenac; Aceclofenac; Articular chondrocyte, rabbit; Osteoarthritis; Pro matrix metalloproteinase 1; Pro matrix metalloproteinase 3; Rheumatoid arthritis

Indexed keywords

4' HYDROXYACLOFENAC; ACECLOFENAC; COLLAGENASE; GLYCOSAMINOGLYCAN POLYSULFATE; METALLOPROTEINASE; STROMELYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; FEMALE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; RABBIT; RHEUMATOID ARTHRITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARTILAGE, ARTICULAR; CELL DIVISION; CELLS, CULTURED; CHONDROCYTES; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME PRECURSORS; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOSAMINOGLYCANS; INTERLEUKIN-1; MATRIX METALLOPROTEINASES; RABBITS; RNA, MESSENGER; SYNOVIAL MEMBRANE;

EID: 0034637288     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00472-6     Document Type: Article

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