Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 1, 2002, Pages 264-273

  Bowen, Carrie A ^a   Fischer, Bradford D ^a   Mello, Nancy K ^a   Stevens Negus, S ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MCLEAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAMORPHINE; MORPHINE; NALTREXONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; CROSS TOLERANCE; DISCRIMINATIVE STIMULUS; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; REINFORCEMENT; RHESUS MONKEY; SPECIES DIFFERENTIATION;

ANALGESICS; ANALGESICS, OPIOID; ANIMALS; CUES; DISCRIMINATION (PSYCHOLOGY); DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT; HEROIN; KINETICS; MACACA MULATTA; MALE; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; PAIN MEASUREMENT; SUBSTANCE-RELATED DISORDERS;

EID: 0036082404     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.1.264     Document Type: Article

References (40)

1. Morphine-6-glucuronide analgesic effects and receptor binding profile in rats
2. Differential influence of N-dealkylation on the stimulus properties of some opioid agonists
3. Antinociceptive effects of 5-opioid agonists in rhesus monkeys: Effects on chemically induced thermal hypersensitivity
4. 3-Methoxynaltrexone, a selective heroin/morphine-6β-glucuronide antagonist
5. 3H-Morphine-6β-glucuronide binding in brain membranes and an MOR-1-transfected cell line
6. Selective D1 and D2 dopamine antagonists decrease response rates of food-maintained behavior and reduce the discriminative stimulus effects produced by heroin
7. κ-opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and β-funaltrexamine
8. Apparent affinity of opioid antagonists in morphine-treated rhesus monkeys discriminating between saline and naltrexone
9. Effects of the structurally novel opioid 14α,14′β-[dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis(7,8- dihydromorphinone) on schedule-controlled behavior and thermal nociception in rhesus monkeys
10. Antinociceptive and respiratory effects of nalbuphine in rhesus monkeys
11. Drug discrimination studies
12. The pharmacokinetics of heroin in patients with chronic pain
13. Evidence from opioid binding sites that heroin acts through its metabolites
14. 2 analysis in rhesus monkeys
15. Absence of cross-tolerance to heroin in morphine-tolerant mice
16. Anatomy of CNS opioid receptors
17. Effects of drug discrimination history on the generalization of pentobarbital to other drugs
18. Effects of opioid agonists selective for μ-, κ-, and δ-opioid receptors on schedule-controlled responding in rhesus monkeys: Antagonism by quadazocine
19. 2-induced hyperalgesia and its reversal by morphine in the warm-water tail-withdrawal procedure in rhesus monkeys
20. Discriminative stimulus effects of a cocaine/heroin "speedball" combination in rhesus monkeys
21. Effects of μ opioid agonists alone and in combination with cocaine and d-amphetamine in rhesus monkeys trained to discriminate cocaine
22. Opioid antinociception in ovariectomized monkeys: Comparison with antinociception in males and effects of estradiol replacement
23. Sex differences in opioid antinociception in rhesus monkeys: Antagonism of fentanyl and U50,488 by quadazocine
24. Morphine-6β-glucuronide, a potent μ-agonist
25. Pharmacological characterization of morphine-6β-glucuronide, a very potent morphine metabolite
26. Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: Opioid and dopaminergic mechanisms
27. Morphine tolerance in mice changes response of heroin from μ- to δ-opioid receptors
28. Novel receptor mechanisms for heroin and morphine-6β-glucuronide analgesia
29. Antisense mapping of MOR-1 in rats: Distinguishing between morphine and morphine-6β-glucuronide antinociception
30. Antisense mapping the MOR-1 opioid receptor: Evidence for alternative splicing and a novel morphine-6β-glucuronide receptor
31. Differential blockade of morphine and morphine-6β-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein alpha subunits in rats
32. Self-administration of cocaineheroin combinations by rhesus monkeys: Antagonism by naltrexone
33. Retention of heroin and morphine-6β-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1
34. Relationship between the discriminative stimulus properties and subjective effects of drugs
35. Further evaluation of the discriminative stimulus effects of morphine in the rat
36. Antagonism of heroin and morphine self-administration in rats by the morphine-6β-glucuronide antagonist 3-O-methylnaltrexone
37. The pharmacologic effects of heroin in relationship to its rate of biotransformation