Antagonism of heroin and morphine self-administration in rats by the morphine-6β-glucuronide antagonist 3-O-methylnaltrexone

European Journal of Pharmacology

Volumn 383, Issue 2, 1999, Pages 115-119

  Walker, John R ^a   King, Michael ^b   Izzo, Emanuela ^a   Koob, George F ^a   Pasternak, Gavril W ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Addiction; Drug abuse; Heroin; Morphine; Morphine 6 glucuronide; Self administration

Indexed keywords

3 O METHYLNALTREXONE; DIAMORPHINE; MORPHINE; MORPHINE 6 ACETATE; MORPHINE 6 GLUCURONIDE; NALOXONE; OPIATE ANTAGONIST; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG SELF ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; RAT; REINFORCEMENT; SUBCUTANEOUS DRUG ADMINISTRATION; TAIL FLICK TEST;

ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; HEROIN; INJECTIONS, SUBCUTANEOUS; MALE; MORPHINE; MORPHINE DERIVATIVES; NALTREXONE; NARCOTIC ANTAGONISTS; NARCOTICS; PAIN MEASUREMENT; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SELF ADMINISTRATION;

EID: 0032758835     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00633-0     Document Type: Article

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