Novel poly(ethylene glycol) derivatives for preparation of ribosome-inactivating protein conjugates

Bioconjugate Chemistry

Volumn 13, Issue 4, 2002, Pages 757-765

  Arpicco, Silvia ^a   Dosio, Franco ^a   Bolognesi, Andrea ^b   Lubelli, Chiara ^b   Brusa, Paola ^a   Stella, Barbara ^a   Ceruti, Maurizio ^c   Cattel, Luigi ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b Dipartimento di Patologia Sperimentale   (Italy)

^c Tossicologico e Biologico   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; CHAINS; CYTOTOXICITY; ETHYLENE GLYCOL; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; POLYOLS; PROTEINS;

AMINO GROUP; CYTOTOXIC; GLYCOL DERIVATIVES; HYDROXYL GROUPS; POSITIVE CHARGES; PROTEIN CONJUGATES; REACTIVE GROUP; RIBOSOME-INACTIVATING PROTEIN; SINGLE CHAINS; SPACER ARMS;

ETHYLENE;

CROSS LINKING REAGENT; GEL PROTEIN, GELONIUM MULTIFLORUM; MACROGOL DERIVATIVE; MONOMETHOXYPOLYETHYLENE GLYCOL; PROTEIN SYNTHESIS INHIBITOR; VEGETABLE PROTEIN;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BAGG ALBINO MOUSE; CELL FREE SYSTEM; CHEMISTRY; DRUG EFFECT; FEMALE; HALF LIFE TIME; IC 50; IMMUNOLOGY; MOUSE; RABBIT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL-FREE SYSTEM; CROSS-LINKING REAGENTS; FEMALE; HALF-LIFE; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED BALB C; ORGAN SPECIFICITY; PLANT PROTEINS; POLYETHYLENE GLYCOLS; PROTEIN SYNTHESIS INHIBITORS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036079378     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc015578s     Document Type: Article

References (57)

1. Ribosome-inactivating proteins from plants: More than RNA N-glycosidases?
2. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins
3. Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: Effect on DNA, RNA and poly(A)
4. Targeted toxins
5. Immunotoxins in cancer therapy
6. Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies
7. A phase II study of effect of addition of trichosanthin to zidovudine in patients with HIV disease and failing antiretroviral agents
8. Trichosanthin, alpha-momorcharin and beta-momorcharin: Identity of abortifacient and ribosome-inactivating proteins
9. Recombinant immunotoxins directed against the c-erb-2/HER2/neu oncogene product: In vitro cytotoxicity, pharmacokinetics, and in vivo efficacy studies in xenograft models
10. Humanized M195 monoclonal antibody conjugated to recombinant gelonin: An anti-CD33 immunotoxin with antileukemic activity
11. Combination of antiviral immunotoxin and ganciclovir or cidofovir for the treatment of murine cytomegalovirus infections
12. The plant ribosome inactivating proteins luffin and saporin are potent inhibitors of HIV-1 integrase
13. Cell surface receptor directed targeting of toxin to human malaria parasite, Plasmodium falciparum
14. Gelonin is an unusual DNA glycosylase that removes adenine from single-stranded DNA, normal base pairs and mismatches
15. A new class of DNA glycosylase/apurinic/apyrimidinic lyases that act on specific adenines in single-stranded DNA
16. New coupling reagents for the preparation of disulfide cross-linked conjugates with increased stability
17. Synthesis of different immunotoxins composed by ribosome inactivating proteins non-covalently bound to monoclonal antibody
18. A new approach in the synthesis of immunotoxins: Ribosome inactivating protein noncovalently bound to monoclonal antibody
19. Toxin-targeted design for anticancer therapy. II: Preparation and biological comparison of different chemically linked gelonin-antibody conjugates
20. Blood clearance and organ distribution and tissue concentration of native, homopolymerized and IgG-conjugated ribosome-inactivating proteins
21. Immunotoxins containing single-chain ribosome-inactivating proteins
22. Site-directed poly(ethylene glycol) modification of trichosanthin: Effects on its biological activities, pharmacokinteics, and antigenicity
23. Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation
24. In vivo administration of lymphocyte-specific monoclonal antibodies in non-human primates. V. Evidence that humoral immune response to monoclonal antibodies and immunotoxin conjugates abrogates their cytotoxic activity
25. The uses and properties of PEG-linked proteins
26. The conjugation of proteins with polyethylene glycol and other polymers: Altering properties of protein to enhance their therapeutic potential
27. Use of functionalized polyethylene glycols for modification of polipeptides
28. Long-acting growth hormones produced by conjugation with polyethylene glycol
29. Cytotoxicity acquired by conjugation of an anti-Thy1.1 monoclonal antibody and the ribosome-inactivating protein, gelonin
30. Purified immunotoxins that are reactive with human lymphoid cells. Monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins
31. A new 'solid phase' procedure to synthesize immunotoxins (antibody-ribosome inactivating protein conjugates)
32. Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A
33. Largescale chromatographic purification of ribosome-inactivating proteins
34. The chemistry of imidates
35. Determination of free amino groups in proteins by trinitrobenzenesulfonic acid
36. Synthesis of hemoglobin in a cell free system. Properties of the complete system
37. Targeting of saporin to CD25-positive normal and neoplastic lymphocytes by an anti-saporin/anti-CD25 bispecific monoclonal antibody: In vitro evaluation
38. Enzyme-linked immunosorbent assay, ELISA. Quantitation of specific antibodies by enzyme labeled anti immunoglobulin in antigen-coated tubes
39. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,2,4,6-tetrachloro-3a,6a-diphenylglycouril
40. Synthesis of monocarboxylic polyoxyethylenes
41. Amino acid sequence analysis, gene construction, cloning, and expression of gelonin, a toxin derived from Gelonium multiflorum
42. Comparative cytotoxicity and pharmacokinetics of antimelanoma immunotoxins containing either natural or recombinant gelonin
43. Site-specific chemical modification with polyethylene glycol) of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity
44. In vitro anti-tumour activity of anti-CD80 and anti-CD86 immunotoxins containing type 1 ribosome-inactivating proteins
45. Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization
46. Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin
47. Shock wave permeabilization with ribosome inactivating proteins: A new approach to tumor therapy
48. Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates
49. Amidination
50. Formation of non-amidine products in the reaction of primary amine with imido esters
51. S-Methylthioacetidate is a new reagent for amidination of proteins at low pH
52. Conjugation of folate via gelonin carbohydrate residues retains ribosomal-inactivating properties of the toxin and permits targeting to folate receptor positive cells
53. Stabilization of substances in circulation
54. Rationale for the use of immunotoxins in the treatment of HIV-infected humans
55. Pharmacokinetics in the rat of a panel of immunotoxins made with abrin A chain, ricin A chain, gelonin, and momordin
56. Design, characterization and anti-tumour cytotoxicity of a panel of recombinant, mammalian ribonuclease-based immunotoxins