Salmonella enterica serovar Typhi live vector vaccines delivered intranasally elicit regional and systemic specific CD8+ major histocompatibility class I-restricted cytotoxic T lymphocytes

Infection and Immunity

Volumn 70, Issue 8, 2002, Pages 4009-4018

  Pasetti, Marcela F ^a   Salerno Gonçalves, Rosangela ^a   Sztein, Marcelo B ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; LIVE VACCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TYPHOID VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SELECTION; CERVICAL LYMPH NODE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DOSE RESPONSE; EFFECTOR CELL; IMMUNIZATION; IMMUNOGENICITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA ENTERICA; SEROTYPE; SPLEEN; SPLEEN CELL; T LYMPHOCYTE; TYPHOID FEVER; VACCINATION;

ADMINISTRATION, INTRANASAL; ANIMALS; CELLS, CULTURED; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SALMONELLA TYPHI; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TYPHOID FEVER; TYPHOID-PARATYPHOID VACCINES; VACCINES, ATTENUATED; VACCINES, SYNTHETIC;

EID: 0036078661     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.8.4009-4018.2002     Document Type: Article

References (52)

1. + cytotoxic T cells
2. Peptide mimics of a tumor antigen induce functional cytotoxic T cells
3. Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908
4. Introduction of protein or DNA delivered via recombinant Salmonella typhimurium into the major histocompatibility complex class I presentation pathway of macrophages
5. H-2L-restricted recognition of viral antigens in the H-2d haplotype. Anti-vesicular stomatitis virus cytotoxic T cells are restricted solely by H-2L
6. Oral somatic transgene vaccination using attenuated S. typhimurium
7. Mucosal immune defense: The Salmonella typhimurium model
8. Mucosal DNA vaccine immunization against measles with a highly attenuated Shigella flexneri vector
9. Generation of a cytotoxic T-lymphocyte response using a Salmonella antigen-delivery system
10. A murine model of intranasal immunization to assess the immunogenicity of attenuated Salmonella typhi live vector vaccines in stimulating serum antibody responses to expressed foreign antigens
11. NKT cells: Facts, functions and fallacies
12. Salmonella typhi vaccine strain CVD 908 expressing the circumsporozoite protein of Plasmodium falciparum: Strain construction and safety and immunogenicity in humans
13. Immune response to porins isolated from Salmonella typhi in different mouse strains
14. Immunogenicity of a Salmonella typhi CVD 908 candidate vaccine strain expressing the major surface protein gp63 of Leishmania mexicana
15. + T cells in acquired immunity and granuloma formation
16. Salmonella typhimurium aro A-infection in gene-targeted mice
17. Optimization of a peptide-based protocol employing IL-7 for in vitro restimulation of human cytotoxic T lymphocyte precursors
18. Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens
19. Optimism over vaccines administered via mucosal surfaces
20. Duration of efficacy of Ty21a, attenuated Salmonella typhi live oral vaccine
21. Attenuated Salmonella as live oral vaccines against typhoid fever and as live vectors
22. Progress in the development of new attenuated strains of Salmonella typhi as live oral vaccines against typhoid fever
23. Host-Salmonella interaction: Human trials
24. + T cells in immunity to Salmonella infection and the involvement of MHC class Ib molecules
25. Macrophages present exogenous antigens by class I major histocompatibility complex molecules via a secretory pathway as a consequence of interferon-gamma activation
26. Adoptive transfer of immunity to oral challenge with virulent salmonellae in innately susceptible BALB/c mice requires both immune serum and T cells
27. Role of T cells. TNF alpha and IFN gamma in recall of immunity to oral challenge with virulent salmonellae in mice vaccinated with live attenuated aro-Salmonella vaccines
28. + T cell responses during natural infection with Salmonella typhimurium
29. Immune response to infection with Salmonella typhimurium in mice
30. Nasal vaccination with attenuated Salmonella typhimurium strains expressing the hepatitis B nucleocapsid: Dose response analysis
31. + T cells and T-independent mechanisms in acquired resistance to Salmonella typhimurium infection
32. Attenuated ΔguaBA Salmonella typhi vaccine strain CVD 915 as a live vector utilizing prokaryotic or eukaryotic expression systems to deliver foreign antigens and elicit immune responses
33. A comparison of immunogenicity and in vivo distribution of Salmonella enterica serovar Typhi and Typhimurium live vector vaccines delivered by mucosal routes in the murine model
34. In vivo characterization of the murine intranasal model for assessing the immunogenicity of attenuated Salmonella enterica serovar Typhi strains as live mucosal vaccines and as live vectors
35. + cytotoxic T lymphocytes following primary and secondary Salmonella infection
36. CTL epitopes identified with a defective recombinant adenovirus expressing measles virus nucleoprotein and evaluation of their protective capacity in mice
37. Salmonella typhimurium aroA, htrA, and aroD htrA mutants cause progressive infections in athymic (nu/nu) BALB/c mice
38. Molecules related to class-I major histocompatibility complex antigens
39. Cytotoxic T lymphocytes after oral immunization with attenuated vaccine strains of Salmonella typhi in humans
40. Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella typhi
41. Safety and immune responses to attenuated Salmonella enterica serovar Typhi oral live vector vaccines expressing tetanus toxin fragment C
42. Clinical acceptability and immunogenicity of CVD 908 Salmonella typhi vaccine strain
43. Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans
44. Phase 2 clinical trial of attenuated Salmonella enterica serovar Typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers
45. Survival-promoting activity of IL-7 on IL-2-dependent cytotoxic T lymphocyte clones: Resultant induction of G1 arrest
46. Salmonella typhimurium ΔaroA ΔaroD mutants expressing a foreign recombinant protein induce specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes in mice
47. Delivery of class I and class II MHC-restricted T-cell epitopes of listeriolysin of Listeria monocytogenes by attenuated Salmonella
48. Construction, genotypic and phenotypic characterization, and immunogenicity of attenuated ΔguaBA Salmonella enterica serovar Typhi strain CVD 915
49. Development of antibody-secreting cells and antigen-specific T cells in cervical lymph nodes after intranasal immunization
50. Salmonella typhi flagella are potent inducers of proinflammatory cytokine secretion by human monocytes
51. Dissemination and proliferation of Salmonella typhimurium in genetically resistant and susceptible mice
52. In vivo activation of dendritic cells and T cells during Salmonella enterica serovar Typhimurium infection