A murine model of intranasal immunization to assess the immunogenicity of attenuated Salmonella typhi live vector vaccines in stimulating serum antibody responses to expressed foreign antigens

Vaccine

Volumn 15, Issue 6-7, 1997, Pages 700-708

  Galen, James E ^a   Gomez Duarte, Oscar G ^a,b   Losonsky, Genevieve A ^a   Halpern, Jane L ^c   Lauderbaugh, Carol S ^d   Kaintuck, Shevon ^a   Reymann, Mardi K ^a   Levine, Myron M ^a  

^a University of Maryland School of Medicine Center for Vaccine Development   (United States)

^b MAX PLANCK INST FÜR BIOLOGIE   (Germany)

^c CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; IMMUNOGLOBULIN G ANTIBODY; TETANUS TOXIN; TYPHOID VACCINE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; IMMUNOGENICITY; INTRAGASTRIC DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE DIAGNOSIS; SALMONELLA TYPHI; STRAIN DIFFERENCE; VACCINATION;

EID: 0030959610     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(96)00227-7     Document Type: Article

References (45)

1. Clements, J.D., Lyon, F.L., Lowe, K.L., Farrand, A.L. and El-Morshidy, S. Oral immunization of mice with attenuated Salmonella enteritidis containing a recombinant plasmid which encodes for production of the B subunit of heat-labile Escherichia coli enterotoxin. Infect. Immun. 1986, 53, 685-692
2. Curtiss, R.I., Kelly, S.M., Gulig, P.A. and Nakayama, K. Selective delivery of antigens by recombinant bacteria. Curr. Top. Microbiol. Immunol. 1989, 146, 35-49
3. Dougan, G., Hormaeche, C.E. and Maskell, D.J. Live oral Salmonella vaccines: potential use of attentuated strains as carriers of heterologous antigens to the immune system. Parasite Immunol. 1987, 9, 151-160
4. Fairweather, N.F., Chatfield, S.N. and Makoff, A.J. et al. Oral vaccination of mice against tetanus by use of a live attenuated Salmonella carrier. Infect. Immunol. 1990, 58, 1323-1326
5. Formal, S.B., Baron, L.S., Kopecko, D.J., Washington, O., Powell, C. and Life, C.A. Construction of a potential bivalent vaccine strain: introduction of Shigella sonnei form I antigen genes into the gaIE Salmonella typhi Ty21a typhoid vaccine strain. Infect. Immun. 1981, 34, 746-750
6. Langermann, S., Palaszynski, S., Sadziene, A., Stover, C.K. and Koenig, S. Systemic and mucosal immunity induced by BCG vector expressing outer-surface protein A of Borrelia burgdorferi. Nature 1994, 372, 552-555
7. Levine, M.M., Hone, D., Heppner, D.G., Noriega, F. and Sriwathana, B. Attenuated Salmonella as carriers for the expression of foreign antigens. Microecol. Ther. 1990, 19, 23-32
8. Noriega, F.R., Losonsky, G., Wang, J.Y., Formal, S.B. and Levine, M.M. Further characterization of aroA, virG Shigella flexneri 2a strain CVD 1203 as a mucosal Shigella vaccine and as a live vector vaccine for delivering antigens of enterotoxigenic Escherichia coli. Infect. Immunol. 1996, 64, 23-27
9. Schodel, F. Prospects for oral vaccination using recombinant bacteria expressing viral epitopes. Adv. Virus Res. 1992, 41, 409-446
10. Gonzalez, C., Hone, D. and Noriega, F. et al. Salmonella typhi vaccine strain CVD 908 expressing the circumsporozoite protein of Plasmodium falciparum: strain construction and safety and immunogenicity in humans. J. Infect. Dis. 1994, 169, 927-931
11. Khan, C.M.A., Villarreal-Ramos, B. and Pierce, R.J. et al. Construction, expression, and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of Salmonella. Proc. Natl Acad. Sci. USA 1994, 91, 11261-11265
12. Chatfield, S.N., Charles, I.G. and Makoff, A.J. et al. Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine. Bio/Technology 1992, 10, 888-892
13. Sztein, M., Tanner, M.K., Polotsky, Y., Orenstein, J.M. and Levine, M.M. Cytotoxic T lymphocytes after oral immunization with attenuated vaccine strains of Salmonella typhi in humans. J. Immunol. 1995, 155, 3987-3993
14. Sztein, M.B., Wasserman, S.S. and Tacket, C.O. et al. Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella typhi. J. Infect. Dis. 1994, 170, 1508-1517
15. Khan, C.M.A., Villarreal-Ramos, B. and Pierce, R.J. et al. Construction, expression, and immunogenicity of multiple tandem copies of the Schistosoma mansoni peptide 115-131 of the P28 glutathione S-transferase expressed as C-terminal fusions to tetanus toxin fragment C in a live Aro-attenuated vaccine strain of Salmonella. J. Immunol. 1994, 153, 5634-5642
16. Walker, M.J., Rohde, M., Timmis, K.N. and Guzman, C.A. Specific lung mucosal and systemic immune responses after oral immunization of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit. Infect. Immunol. 1995, 60, 4260-4268
17. Clements, J.D. and El-Morshidy, S. Construction of a potential live oral bivalent vaccine for typhoid fever and cholera-Escherichia coli-related diarrheas. Infect. Immunol. 1984, 46, 564-569
18. Black, R.E., Levine, M.M. and Clements, M.L. et al. Prevention of shigellosis by a Salmonella typhi-Shigella sonnei bivalent vaccine. J. Infect. Dis. 1987, 155, 1260-1265
19. Tacket, C.O., Forrest, B. and Morona, R. et al. Safety, immunogenicity, and efficacy against cholera challenge in humans of a typhoid-cholera hybrid vaccine derived from Salmonella typhi Ty21a. Infect. Immunol. 1990, 58, 1620-1627
20. Hone, D.M., Harris, A.M., Chatfield, S., Dougan, G. and Levine, M.M. Construction of genetically-defined double aro mutants of Salmonella typhi. Vaccine 1991, 9, 810-816
21. Tacket, C.O., Hone, D.M. and Curtiss, R.I. et al. Comparison of the safety and immunogenicity of ΔaroC, ΔaroD and Δcya, Δcrp Salmonella typhi strains in adult volunteers. Infect. Immunol. 1992, 60, 536-541
22. Tacket, C.O., Hone, D.M., Losonsky, G.A., Guers, L., Edelman, R. and Levine, M.M. Clinical acceptability and immunogenicity of CVD 908 Salmonella typhi vaccine strain. Vaccine 1992, 10, 443-446
23. Giron, J.A., Xu, J.-G., Gonzalez, C.R., Hone, D.M., Kaper, J.B. and Levine, M.M. Simultaneous constitutive expression of CFA/I and CS3 colonization factors of enterotoxigenic Escherichia coli by ΔaroC, ΔaroD Salmonella typhi vaccine strain CVD 908. Vaccine 1995, 10, 939-946
24. Gomez-Duarte, O., Galen, J., Chatfield, S.N., Rappuoli, R., Eidels, L. and Levine, M.M. Expression of fragment C of tetanus toxin fused to a carboxyl-terminal fragment of diphtheria toxin in Salmonella typhi CVD 908 vaccine strain. Vaccine 1995, 13, 1596-1602
25. Fouts, T.R., Lewis, G.K. and Hone, D.M. Construction and characterization of a Salmonella typhi-based human immunodeficiency virus type 1 vector vaccine. Vaccine 1995, 13, 561-569
26. Carter, P.B. and Collins, F.M. Growth of typhoid and paratyphoid bacilli in intravenously infected mice. Infect. Immunol. 1974, 10, 816-822
27. O'Brien, A.D. Innate resistance of mice to Salmonella typhi infection. Infect. Immunol. 1982, 38, 948-952
28. Gerichter, C.B. The dissemination of Salmonella typhi, S. paratyphi A and S. paratyphi B through the organs of the white mouse by oral infection. J. Hyg. Camb. 1960, 58, 307-319
29. Gerichter, C.B. and Boros, D.L. Dynamics of infection of the blood stream and internal organs of white mice with Salmonella typhi by intraperitoneal injection. J. Hyg. Camb. 1962, 60, 311-321
30. Oxer, M.D., Bentley, C.M., Doyle, J.G., Peakman, T.C., Charles, I.G. and Makoff, A.J. High level heterologous expression in E. coli using the anaerobically-activated nirB promoter. Nucleic Acids Res. 1991, 19, 2889-2892
31. 4-fold amplification of Escherichia coli minor protein. Bio/Technology 1984, 2, 81-85
32. Hoiseth, S. and Stocker, B.A.D. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 1981, 292, 238-239
33. Noriega, F.R., Wang, J.Y., Losonsky, G., Maneval, D.R., Hone, D.M. and Levine, M.M. Construction and characterization of attenuated Δ aroA Δ virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine. Infect. Immunol. 1995, 65, 5168-5172
34. Barile, M.F., Hardegree, M.C. and Pittman, M. Immunization against neonatal tetanus in New Guinea. Bull. WHO 1970, 43, 453-459
35. Gizurarson, S. Animal models for intranasal drug delivery studies: a review article. Acta Pharm. Nord. 1990, 2, 105-122
36. Rolf, J.M. and Eidels, L. Structure-function analyses of diphtheria toxin by use of monoclonal antibodies. Infect. Immunol. 1993, 61, 994-1003
37. Ivanoff, B., Andre, C., Fontanges, R. and Jourdan, G. Secondary immune response to oral and nasal rough mutant strains of Salmonella typhimurium. Ann. Immunol. 1982, 133D, 61-70
38. Orr, N., Robin, G., Cohen, D., Arnon, R. and Lowell, G.H. Immunogenicity and efficacy of oral or intranasal Shigella flexneri 2a and Shigella sonnei. Infect. Immunol. 1993, 61, 2390-2395
39. Douce, G., Turcotte, C. and Cropley, I. et al. Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants. Proc. Natl Acad. Sci. USA 1995, 92, 1644-1648
40. Barry, E.M., Gomez-Duarte, O., Chatfield, S., Rappuoli, R., Losonsky, G.A., Galen, J.E. and Levine, M.M. Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908. Infect. Immunol. (in press)
41. Cárdenas, L., Dasgupta, U. and Clements, J.D. Influence of strain viability and antigen dose on the use of attenuated mutants of Salmonella as vaccine carriers. Vaccine 1995, 12, 833-840
42. Kuper, C.F., Koornstra, P.J. and Hameleers, D.M.H. et al. The role of nasopharyngeal lymphoid tissue. Immunol. Today 1992, 13, 219-224
43. Spit, B.J., Hendriksen, E.G.J., Bruijintjes, J.P. and Kuper, C.F. Nasal lymphoid tissue in the rat. Cell Tissue Res. 1989, 225, 193-198
44. McGhee, J.R., Mestecky, J., Dertzbaugh, M.T., Eldridge, J.H., Hirasawa, M. and Kiyono, H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 1992, 10, 75-88
45. Holt, P.G. and Sedgwick, J.D. Suppression of IgE responses following inhalation of antigen. Immunol. Today 1987, 8, 14-15