Disruption of the gene homologous to mammalian Nramp1 in Mycobacterium tuberculosis does not affect virulence in mice

Infection and Immunity

Volumn 70, Issue 8, 2002, Pages 4124-4131

  Boechat, Neio ^a   Lagier Roger, Béatrice ^a   Petit, Stéphanie ^a   Bordat, Yann ^a   Rauzier, Jean ^a   Hance, Allan J ^a   Gicquel, Brigitte ^a   Reyrat, Jean Marc ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1;

ANIMAL CELL; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CONTROLLED STUDY; GENE DISRUPTION; GENE INACTIVATION; MACROPHAGE; MOUSE; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TISSUE DISTRIBUTION;

ANIMALS; BACTERIAL PROTEINS; BONE MARROW CELLS; CATION TRANSPORT PROTEINS; CELLS, CULTURED; CULTURE MEDIA; FEMALE; GENE TARGETING; IRON; MACROPHAGES; MICE; MICE, INBRED BALB C; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; VIRULENCE;

EID: 0036077222     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.8.4124-4131.2002     Document Type: Article

References (54)

1. Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family
2. High level expression of Nramp1G169 in RAW 1264.7 cell transfectants: Analysis of intracellular iron transport
3. Hematological and iron-related measurements in active pulmonary tuberculosis
4. The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague
5. Regulation of Leishmania populations within the host. II. Genetic control of acute susceptibility of mice to Leishmania donovani infection
6. Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis
7. Resistance to intracellular infections: Comparative genomic analysis of Nramp
8. Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue specific expression
9. Nramp defines a family of membrane proteins
10. Construction and characterization of a Mycobacterium tuberculosis mutant lacking the alternate sigma factor gene sigF
11. Massive gene decay in the leprosy bacillus
12. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
13. The many faces of host response to tuberculosis
14. Stability constants of metal complexes
15. Bone marrow macrophage iron grade and survival of HIV-seropositive patients
16. Iron acquisition and metabolism by mycobacteria
17. The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages
18. Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall
19. Evidence for a link between iron metabolism and Nrampl gene function in innate resistance to Mycobacterium avium
20. +/bivalent cation antiporter
21. Functional expression of Nramp1 in vitro after transfection into murine macrophage line RAW264.7
22. The Ith/Lsh/Bcg locus: Genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele
23. Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice
24. Natural resistance to intracellular parasites: The Nrampl protein is recruited to the membrane of the phagosome
25. Host resistance to intracellular infection: Mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification
26. Natural resistance to intracellular infections: Natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane
27. Phosphatidylinositol is an essential phospholipid of mycobacteria
28. Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine
29. Induction of nitric oxide in human monocytes and monocytes cell lines by Mycobacterium tuberculosis
30. Iron, infections and anemia of inflammation
31. The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen
32. Tuberculostatic activity of normal sera
33. Genetic control of resistance to experimental infection with virulent Mycobacterial tuberculosis
34. Gly169-transfected RAW264.7 macrophage cell line
35. Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter
36. Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor
37. Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection
38. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
39. Resistance ranking of some common inbred mouse strains to Mycobacterium tuberculosis and relationship to major histocompatibility haplotype and Nramp1 genotype
40. Consequence of Nramp1 deletion to Mycobacterium tuberculosis infection in mice
41. Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis
42. An essential role for phoP in Mycobacterium tuberculosis virulence
43. Genetics of resistance to infection with Salmonella typhimurium in mice
44. Rapid assessment of mycobacterial growth inside macrophages and mice, using the radiometric (BACTEC) method
45. Mycobacterium avium and Mycobacterium tuberculosis-containing vacuoles are dynamic, fusion competent vesicles that are accessible to glycosphingolipids from the host cell plasmalemma
46. Sur la nutrition minerale du bacille tuberculeux
47. Genetic regulation of resistance to intracellular pathogens
48. Phenotypic expression of genetically controlled natural resistance to Mycobacterium bovis (BCG)
49. The COG database: New developments in phylogenetic classification of proteins from complete genomes
50. Mycobacterial infection of macrophages results in membrane-permeable phagosomes
51. The Ith/Lsh/Bcg locus: Natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene
52. A whole blood bactericidal assay for tuberculosis
53. Attenuation of MHC class II expression in macrophages infected with Mycobacterium bovis bacillus Calmette-Guerin involves class II transactivator and depends on the Nramp1 gene
54. Role of iron in Nramp1-mediated inhibition of mycobacterial growth