Structural determinants for the action of grayanotoxin in D1 S4-S5 and D4 S4-S5 intracellular linkers of sodium channel α-subunits

Biochemical and Biophysical Research Communications

Volumn 295, Issue 2, 2002, Pages 452-457

  Maejima, Hiroshi ^a   Kinoshita, Eiji ^a   Yuki, Tsunetsugu ^a   Yakehiro, Masuhide ^b   Seyama, Issei ^a   Yamaoka, Kaoru ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

Grayanotoxin; Hek 293; S4 S5 linker; Sodium channel; Whole cell patch clamp

Indexed keywords

ALANINE; GRAYANOTOXIN; LEUCINE; MUTANT PROTEIN; PROTEIN SUBUNIT; SERINE; SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOPLASM; DRUG BINDING; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; SEQUENCE HOMOLOGY; VOLTAGE CLAMP;

ALANINE; ANIMALS; CELLS, CULTURED; DITERPENES; ION CHANNEL GATING; KINETICS; MUTAGENESIS; PROTEIN CONFORMATION; RATS; SODIUM CHANNELS; TOXINS, BIOLOGICAL;

EID: 0036064140     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00702-7     Document Type: Article

References (24)

1. Structure-activity relationship for grayanotoxin derivatives in frog skeletal muscle
2. Effect of structural modification of several groups on the D-ring of grayanotoxin on its depolarization potency in squid giant axon
3. Structure-activity relationship for D-ring derivatives of grayanotoxin in the squid giant axon
4. + channels in frog ventricular myocytes
5. + channel isoforms
6. On site of action of grayanotoxin in domain 4 segment 6 of rat skeletal muscle sodium channel
7. Novel site on sodium channel α-subunit responsible for the differential sensitivity of grayanotoxin in skeletal and cardiac muscle
8. Primary structure and functional expression of a mammalian skeletal muscle sodium channel
9. + channel isoform
10. Novel wasp toxin discriminates between neuronal and cardiac sodium channels
11. Grayanotoxin opens Na channels from inside the squid axonal membrane
12. An analysis of the variations in potency of grayanotoxin analogs in modifying frog sodium channels of differing subtypes
13. Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides
14. Neuronal ion channels as the target sites of insecticides
15. Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker
16. Interaction between the sodium channel inactivation linker and domain III S4-S5
17. A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel α-subunit in fast inactivation
18. + channel mutation associated with paramyotonia congenita in a human cell line
19. + channel mutation causing paramyotonia congenital
20. + channel disrupt fast and enhance slow inactivation
21. + channels
22. Primary structure of electrophorus electricus sodium channel deduced from cDNA sequence
23. Evidence for voltage-dependent S4 movement in sodium channels
24. + channel fast inactivation