Aspirin inhibits Chlamydia pneumoniae-induced nuclear factor-κB activation, cytokine expression, and bacterial development in human endothelial cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 7, 2002, Pages 1075-1080

  Tiran, Andreas ^a   Gruber, Hans Jürgen ^a   Graier, Wolfgang F ^a   Wagner, Andreas H ^b   Van Leeuwen, Ellen B M ^c   Tiran, Beate ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Aspirin; Chlamydia pneumoniae; Nuclear factor B; Transcription factor

Indexed keywords

ACETYLSALICYLIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8;

APOPTOSIS; ARTICLE; BACTERIAL GROWTH; CHLAMYDOPHILA PNEUMONIAE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG MECHANISM; ELECTROPHORETIC MOBILITY; ENDOTHELIUM CELL; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HEART PROTECTION; HOST CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; PROGENY;

APOPTOSIS; ASPIRIN; CELL LINE; CHLAMYDOPHILA PNEUMONIAE; ENDOTHELIUM, VASCULAR; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; NF-KAPPA B; UMBILICAL VEINS;

EID: 0036061713     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000022695.22369.BE     Document Type: Article

References (34)

1. Chlamydia pneumoniae (TWAR)
2. Roles of infectious agents in atherosclerosis and restenosis: An assessment of the evidence and need for future research
3. Chlamydia pneumoniae in coronary plaques: Increased detection with acute coronary syndrome
4. Chlamydia pneumoniae infection in human monocytes
5. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells
6. In vitro susceptibility of human vascular wall cells to infection with Chlamydia pneumoniae
7. Expression of adhesion molecules on endothelial cells stimulated by Chlamydia pneumoniae
8. Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line
9. Requirement for NF-kappaB in transcriptional activation of monocyte chemotactic protein 1 by Chlamydia pneumoniae in human endothelial cells
10. Production of basic fibroblast growth factor and interleukin 6 by human smooth muscle cells following infection with Chlamydia pneumoniae
11. Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression: A potential link to accelerated arteriosclerosis
12. Signal transduction pathways activated in endothelial cells following infection with Chlamydia pneumoniae
13. The NF-kappa B and I kappa B proteins: New discoveries and insights
14. Bridging the gap: Composition, regulation, and physiological function of the IkappaB kinase complex
15. New insights into the role of nuclear factor-kappaB in cell growth regulation
16. Inhibition of NF-kappa B by sodium salicylate and aspirin
17. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I kappa B kinase-beta
18. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
19. An SV40 large T-antigen immortalized human umbilical vein endothelial cell line for anti-endothelial cell antibody detection
20. A microcarrier culture method for the production of large quantifies of viable Chlamydia pneumoniae
21. Lymphotoxin inhibits Chlamydia pneumoniae growth in HEp-2 cells
22. Cytokine-inducible CD40 gene expression in vascular smooth muscle cells is mediated by nuclear factor kB and signal transducer and activator of transcription factor-1
23. Aspirin
24. Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate
25. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells
26. Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells
27. Reactive oxygen species as mediators of signal transduction in cardiovascular disease
28. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
29. Activation of NF-kappa B via the Ikappa B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells
30. Survival of Chlamydia pneumoniae-infected Mono Mac 6 cells is dependent on NF-kappaB binding activity
31. Nuclear factor-kappaB and caspases co-operatively regulate the activation and apoptosis of human macrophages
32. Characterization of antiapoptotic activities of Chlamydia pneumoniae in human cells
33. Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis
34. Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection