A non-immunogenic adenoviral vector, coexpressing CTLA4lg and bilirubin-uridine-diphosphoglucuronateglucuronosyltransferase permits long-term, repeatable transgene expression in the Gunn rat model of Crigler-Najjar syndrome

Gene Therapy

Volumn 9, Issue 15, 2002, Pages 981-990

  Thummala, N R ^a   Ghosh, S S ^a   Lee, S W ^a   Reddy, B ^a   Davidson, A ^a   Horwitz, M S ^a   Chowdhury, J Roy ^a   Chowdury, N Roy ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

CTLA4 lg; Gene therapy; Gunn rat; Recombinant adenovirus; UPD glucuronysltransferase

Indexed keywords

ADENOVIRUS VECTOR; B7 ANTIGEN; BILIRUBIN; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCURONOSYLTRANSFERASE; VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ARTICLE; BILIRUBIN BLOOD LEVEL; CELL INFILTRATION; CONTROLLED STUDY; CRIGLER NAJJAR SYNDROME; CYTOMEGALOVIRUS; CYTOTOXIC LYMPHOCYTE; ESCHERICHIA COLI; GENE CONSTRUCT; GENE EXPRESSION; HEPATITIS; HOST; IMMUNE RESPONSE; IMMUNOGENICITY; INFLAMMATORY CELL; LIVER BIOPSY; LIVER CELL; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; RAT STRAIN; T LYMPHOCYTE; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; BILIRUBIN; CRIGLER-NAJJAR SYNDROME; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; GLUCURONOSYLTRANSFERASE; HUMANS; IMMUNOCONJUGATES; LIVER; MALE; MICE; RATS; RATS, GUNN; TIME FACTORS; TRANSGENES;

ADENOVIRIDAE; ANIMALIA; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; DNA VIRUSES; ESCHERICHIA COLI; MURINAE; RATTUS NORVEGICUS;

EID: 0036052121     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301729     Document Type: Article

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