Mutation analysis and association studies of nuclear factor-κB1 in sporadic Parkinson's disease patients

Journal of Neural Transmission

Volumn 109, Issue 9, 2002, Pages 1181-1188

  Wintermeyer, P ^a   Riess, O ^a   Schols L ^b   Przuntek, H ^b   Miterski, B ^a   Epplen, J T ^a   Kruger R ^b  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Genetics; Neurodegeneration; Nuclear factor Kappa B; Parkinson's disease

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; ARTICLE; CHROMOSOME 4Q; CONTROLLED STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; APOPTOSIS; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 4; DNA MUTATIONAL ANALYSIS; EXONS; GENE FREQUENCY; GENETIC SCREENING; GENOTYPE; HUMANS; NF-KAPPA B; OXIDATIVE STRESS; PARKINSON DISEASE; POINT MUTATION; POLYMORPHISM, GENETIC; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036042738     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-001-0688-x     Document Type: Article

References (30)

1. Tumor necrosis factors: Developments during the last decade
2. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
3. Immunocytochemical analysis of tumor necrosis factor and it's receptors in Parkinson's disease
4. Comprehensive human genetic maps: Individual and sex-specific variation in recombination
5. A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor
6. A susceptibility locus for Parkinson's disease maps to chromosome 2p13
7. Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease
8. Transcription factor NF-kappa B is activated in primary neurons by amyloid beta peptides and neurons surrounding early plaques from patients with Alzheimer disease
9. Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis
10. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
11. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
12. Ala30Pro mutation in the gene encoding alpha synuclein in Parkinson's disease
13. Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype
14. Genetic analysis of immunomodulating factors in sporadic Parkinson's disease
15. Antiapoptotic role of NF-kappaB in the auto-oxidized dopamine-induced apoptosis of PC12 cells
16. The ubiquitin pathway in Parkinson's disease
17. Signal transduction through NF- kappa B
18. Cloning of the DNA-binding subunit of human nuclear factor kappa B: The level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha
19. PCR/SSCP detects reliably and efficiently DNA sequence variations in large scale screening projects
20. Cytokines in Parkinson's disease
21. NF-kappa B: A crucial transcription factor for glial and neuronal cell function
22. Mutation in the alpha-synuclein gene identified in families with Parkinson's diesease
23. Genepop (version 1.2): Population genetics software for exact tests and ecumenicism
24. Neuronal death caused by apoptosis in Parkinson's disease
25. Targeted disruption of the p50 subunit of NF-kappa B leads multifocal defects in immune responses
26. HLA and disease - A survey
27. HLA and disease associations: Detecting the strongest association
28. Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies
29. Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36
30. PARK7, a novel locus for autosomal recessive early-onset Parkinsonism, on chromosome 1p36