Novel Mycobacterium tuberculosis anti-σ factor antagonists controls σF activity by distinct mechanisms

Molecular Microbiology

Volumn 45, Issue 6, 2002, Pages 1527-1540

  Beaucher, Jocelyn ^a   Rodrigue, Sébastien ^a   Jacques, Pierre Étienne ^a   Smith, Issar ^b   Brzezinski, Ryszard ^a   Gaudreau, Luc ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIGMA FACTOR;

ADAPTATION; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; DISEASE COURSE; LATENT PERIOD; MUTATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PHYSIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; TUBERCULOSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); SIGMA FACTOR; TRANSCRIPTION, GENETIC;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0036034863     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.03135.x     Document Type: Article

References (44)

1. Alper, S., Duncan, L., and Losick, R. (1994) An adenosine nucleotide switch controlling the activity of a cell type-specific transcription factor in B. subtilis. Cell 77: 195-205.
2. Alper, S., Dufour, A., Garsin, D.A., Duncan, L., and Losick, R. (1996) Role of adenosine nucleotides in the regulation of a stress-response transcription factor in Bacillus subtilis. J Mol Biol 160: 165-177.
3. Bates, P.A., and Sternberg, M.J.E. (1999) Model building by comparison at CASP3. Using Expert Knowledge Computer Automation Proteins Supplement 3: 47-54.
4. Betts, J.C., Lukey, P.T., Robb, L.C., McAdam, R.A., and Duncan, K. (2002) Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol Microbiol 43: 717-731.
5. Busby, S., and Ebright, R.H. (1994) Promoter structure, promoter recognition, and transcription activation in prokaryotes. Cell 79: 743-746.
6. A factor. J Bacteriol 172: 3257-3263.
7. Chen, P., Ruiz, R.E., Li, Q., Silver, R.F., and Bishai, W.R. (2000a) Construction and characterization of a Mycobacterium tuberculosis mutant lacking the alternate sigma factor gene, sigF. Infect Immun 68: 5575-5580.
8. Chen, P., Gomez, J., and Bishai, W.R. (2000b) Mycobacterial transcription regulation in stationary phase. In Molecular Genetics of Mycobacteria. Hatfull, G.F., and Jacobs Jr, W.R. (eds). Washington: American Society for Microbiology Press, pp. 149-156.
9. Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., et al. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393: 537-544.
10. Collins, D.M., Kawakami, R.P., DeLisle, G.W., Pascopella, L., Bloom, B.R., and Jacobs Jr, W.R. (1995) Mutation of the principal σ factor causes loss of virulence in a strain of Mycobacterium tuberculosis complex. Proc Natl Acad Sci USA 92: 8036-8040.
11. DeMaio, J., Zhang, Y., Ko, C., Young, D.B., and Bishai, W.R. (1996) A stationary-phase stress-response sigma factor from Mycobacterium tuberculosis. Proc Natl Acad Sci USA 93: 2790-2794.
12. DeMaio, J., Zhang, Y., Ko, C., and Bishai, W.R. (1997) Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber Lung Dis 78: 3-12.
13. Dufour, A., and Haldenwang, W.G. (1994) Interaction between a Bacillus subtilis anti-σ factor (RsbW) and its antagonist (RsbV). J Bacteriol 176: 1813-1820.
14. F from its anti-sigma factor SpoIIAB. J Mol Biol 260: 147-164.
15. Fernandes, N.D., Wu, Q.L., Kong, D., Puyang, W., Garg, S., and Husson, R.N. (1999) A mycobacterial extracytoplasmic sigma factor involved in survival following heat shock and oxydative stress. J Bacteriol 172: 4266-4274.
16. Gaur, N.K., Cabane, K., and Smith, I. (1988) Structure and expression of the Bacillus subtilis sin operon. J Bacteriol 170: 1046-1053.
17. Ghosh, P., Ishihama, A., and Chatterji, D. (2001) Escherichia coli RNA polymerase subunit ω and its N-terminal domain bind full-length b to facilitate incorporation into the a2b subassembly. Eur J Biochem 268: 4621-4627.
18. Glickman, M.S., and Jacobs Jr, W.R. (2001) Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline. Cell 104: 477-485.
19. Gomez, M., Doukhan, L., Nair, G., and Smith, I. (1998) sigA is an essential gene in Mycobacterium smegmatis. Mol Microbiol 29: 617-628.
20. Graham, J.E., and Clark-Curtiss, R. (1999) Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS). Proc Natl Acad Sci USA 96: 11554-11559.
21. Gross, C.A., Chan, C., Dombroski, A., Gruber, T., Sharp, M., Tupy, J., and Young, B. (1998) The functional and regulatory roles of sigma factors in transcription. In Cold Spring Harb Symp Quant Biol LXIII. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, pp. 141-155.
22. Hecker, M., Schumann, W., and Völker, U. (1996) Heat-shock and general stress response in Bacillus subtilis. Mol Microbiol 19: 417-428.
23. Helmann, J.D. (1999) Anti-sigma factors. Curr Opin Microbiol 2: 135-141.
24. Hughes, K.T., and Mathee, K. (1998) The anti-sigma factors. Ann Rev Microbiol 52: 231-286.
25. F in Bacillus subtilis. J Biomol NMR 19: 293-304.
26. Kuznedelov, K., Minakhin, L., Niedziela-Majka, A., Dove, S.L., Rogulja, D., Nickels, B.E., et al. (2002) A role for interaction of the RNA polymerase flap domain with the s subunit in promoter recognition. Science 295: 855-857.
27. Lee, C.S., Lucet, I., and Yudkin, M.D. (2000) Fate of the SpoIIAB*-ADP liberated after SpoIIAB phosphorylates SpoIIAA of Bacillus subtilis. J Bacteriol 182: 6250-6253.
28. F factor SpoIIAA lead to a Spo- phenotype. Mol Microbiol 40: 9-19.
29. F activity in sporulating Bacillus subtilis. J Bacteriol 179: 3922-3927.
30. Manganelli, R., Dubnau, E., Tyagi, S., Kramer, F.R., and Smith, I. (1999) Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis. Mol Microbiol 31: 715-724.
31. Manganelli, R., Voskuil, M.I., Schoolnik, G.K., and Smith, I. (2001) The Mycobacterium tuberculosis ECF sigma factor σE: role in global gene expression and survival in macrophages. Mol Microbiol 41: 423-437.
32. Michele, M.T., Ko, C., and Bishai, W.R. (1999) Exposure to antibiotics induces expression of the Mycobacterium tuberculosis sigF gene: implications for chemotherapy against mycobacterial persistors. Antimicrob Agents Chemother 43: 218-225.
33. F, the first compartment-specific transcription factor of B. subtilis, is regulated by an anti-σ factor that is also a protein kinase. Cell 74: 735-742.
34. F of Bacillus subtilis. J Bacteriol 177: 2912-2913.
35. R regulon. Mol Microbiol 42: 1007-1020.
36. B-dependent genes in Bacillus subtilis using a promoter consensus-directed search and oligonucleotide hybridization. J Bacteriol 181: 5718-5724.
37. Predich, M., Doukhan, L., Nair, G., and Smith, I. (1995) Characterization of RNA polymerase and two sigma-factor genes from Mycobacterium smegmatis. Mol Microbiol 15: 355-366.
38. Raman, S., Song, T., Puyang, X., Bardarov, S., Jacobs, W.R., and Husson, R.N. (2001) The alternative sigma factor SigH regulates major components of oxydative and heat stress responses in Mycobacterium tuberculosis. J Bacteriol 183: 6119-6125.
39. Rodriguez, R., Chinea, G., Lopez, N., Pons, T., and Vriend, G. (1998) Homology modeling, model and software evaluation: three related resources. CABIOS 14: 523-528.
40. Shafikhani, S.H., Mandic-Mulec, I., Strauch, M.A., Smith, I., and Leighton, T. (2001) Postexponential regulation of sin operon expression in Bacillus subtilis. J Bacteriol 184: 564-571.
41. Tatusov, R.L., Galperin, M.Y., Natale, D.A., and Koonin, E.V. (2000) The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res 28: 33-36.
42. Wayne, L.G., and Hayes, L.G. (1996) An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun 64: 2062-2069.
43. Wayne, L.G., and Sohaskey, C.D. (2001) Nonreplicating persistence of Mycobacterium tuberculosis. Annu Rev Microbiol 55: 139-163.
44. Zhang, G., Campbell, E.A., Minakhin, L., Richter, C., Severinov, K., and Darst, S.A. (1999) Crystal structure of Thermus aquaticus core RNA polymerase at 33 Å resolution. Cell 98: 811-824.