Mutation spectrum of 1,2-dibromo-3-chloropropane, an endorcine disruptor, in the lacI transgenic Big Blue Rat2 fibroblast cell line

Mutagenesis

Volumn 17, Issue 4, 2002, Pages 301-307

  Ryu, Jae Chun ^a   Kim, Youn Jung ^a,b   Chai, Young Gyu ^b  

^a Korea Institute of Science and Technology   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMO 3 CHLOROPROPANE; ADENINE; CYTOSINE; GUANINE; THYMINE; 1,2-DIBROMO-3-CHLOROPROPANE; ANTINEMATODAL AGENT; BACTERIAL PROTEIN; CARCINOGEN; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; LACI PROTEIN, BACTERIA; PROPANE; REPRESSOR PROTEIN;

ANALYSIS OF VARIANCE; ANIMAL CELL; ARTICLE; BASE PAIRING; CALCULATION; CARCINOGENICITY; CELL COUNT; CELL SURVIVAL; CHEMICAL CARCINOGENESIS; CHEMICAL MUTAGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOCRINE SYSTEM; EXPOSURE; FIBROBLAST CULTURE; GENOTOXICITY; MALE GENITAL SYSTEM; MUTAGENICITY; NEMATODE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RAT; SOIL FUMIGATION; SURVIVAL RATE; TRANSGENIC ANIMAL; ANIMAL; CELL LINE; DRUG EFFECT; FIBROBLAST; GENETICS; METHODOLOGY; MUTAGEN TESTING; MUTATION;

ANIMAL; ANIMALS, GENETICALLY MODIFIED; ANTINEMATODAL AGENTS; CARCINOGENS; CELL LINE; CELL SURVIVAL; ESCHERICHIA COLI PROTEINS; FIBROBLASTS; MUTAGENICITY TESTS; MUTATION; PROPANE; RATS; REPRESSOR PROTEINS; ANIMALS; BACTERIAL PROTEINS;

ANIMALIA; NEMATODA;

EID: 0036020633     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. How the lac repressor binds to DNA
2. Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection
3. Method for detecting carcinogens and mutagens with Salmonella/mammalian-microsome mutagenicity test
4. Mutational analysis of the liver, colon and kidney of Big Blue® rats treated with 2-amino-3-methylimidazo[4,5-f]quinoline
5. Organ-specific and transplacental DNA damage and its repair in rats treated with 1,2-dibromo-3-chloropropane
6. Mutational spectra: From model systems to cancer-related genes
7. The use of shuttle vectors for mutation analysis in transgenic mice and rats
8. Overview of mutation assays in transgenic mice for routine testing
9. Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo
10. The micronucleus assay using peripheral blood reticulocytes from mitomycin C- and cyclophosphamide-treated rats
11. The transmission rate of the lacI transgene from the Big Blue™ mouse
12. 7-guanyl adducts derived from 1,2-dibromo-3-chloropropane
13. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans
14. Chromosome test with 134 compounds on Chinese hamster cells in vitro-a screening for chemical carcinogens
15. Y-chromosomal non-disjunction in dibromochloropropane-exposed workmen
16. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice
17. Mutagenic activity of halogenated propanes and propanes: Effect of bromine and chlorine positioning
18. The use of selection in recovery of transgenic targets for mutation analysis
19. Revised methods for the Salmonella mutagenicity test
20. Further mutagenicity studies on pesticides in bacterial reversion assay system
21. The HeLa DNA-synthesis inhibition test as a rapid screen for mutagenic carcinogens
22. Dibromochloropropane (DBCP): An 8-year reevaluation of testicular function and reproductive performance
23. Mutation spectrum in lacI gene of transgenic Big Blue cell line following to short term exposure 4-nitroquinoline-N-oxide
24. Mutation spectrum of 4-nitroquinoline-N-oxide in the lacI transgenic Big Blue® Rat2 cell line
25. Genotoxicity assessment of atrazine in the Big Blue Rat2 lacI transgenic cell line
26. Spermatogenesis in agricultural workers exposed to dibromochloropropane (DBCP)
27. Molecular analysis of lacI mutants from transgenic fibroblasts exposed to 1,2-epoxybutene
28. Mutagenicity of 1,2-dibromo-3-chloropropane (DBCP) in the mouse spot test
29. Detection of in vivo genotoxicity of haloalkanes and haloalkenes carcinogenic to rodents by the alkaline single cell gel electrophoresis (comet) assay in multiple mouse organs
30. Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the E. coli lacI gene
31. The micronucleus test
32. lacI mutation spectra following benzo[a]pyrene treatment of Big Blue® mice
33. Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene
34. Metabolism of 1,2-dibromo-3-chloropropane by glutathione-S-transferases
35. Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: A model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis(2-chloroethyl)-1-nitrosourea
36. Lambda phage shuttle vector for analysis of mutations in mammalian cells in cultures and in transgenic mice
37. Comparison of somatic mutation in a transgenic versus host locus
38. Genetic toxicology of 1,2-dibromo-3-chloropropane (DBCP)
39. Sister-chromatid exchanges and chromosomal aberrations in cultured Chinese hamster cells treated with pesticides positive in microbial reversion assays
40. The Evaluation and Testing of Drugs for Mutagenicity: Principles and Problems