Mutation spectrum of 4-nitroquinoline N-oxide in the lacI transgenic Big Blue® Rat2 cell line

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 445, Issue 1, 1999, Pages 127-135

  Ryu, Jae Chun ^a   Youn, Ji Youn ^a   Kim, Youn Jung ^a   Kwon, Oh Seung ^a   Song, Yun Seon ^a   Kim, Hyung Tae ^a   Cho, Kyung Hae ^b   Chang, Il Moo ^c  

^a Korea Institute of Science and Technology   (South Korea)

^b Seoul Women University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

4 Nitroquinoline N oxide; Big Blue Rat2 cell line; LacI gene; Mutational spectrum

Indexed keywords

4 NITROQUINOLINE 1 OXIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARCINOGENESIS; GENE MUTATION; MUTANT; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TANDEM REPEAT;

4-NITROQUINOLINE-1-OXIDE; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BACTERIAL PROTEINS; BASE SEQUENCE; CELL LINE; DNA; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI PROTEINS; FRAMESHIFT MUTATION; MUTAGENICITY TESTS; MUTAGENS; MUTATION; POINT MUTATION; RATS; REPRESSOR PROTEINS; SEQUENCE DELETION;

EID: 0032829015     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00136-9     Document Type: Article

References (40)

1. Dogliotti E. Mutational spectra: from model systems to cancer-related genes. Carcinogenesis. 17:1996;2113-2118.
2. Gorelick N.J. Overview of mutation assays in transgenic mice for routine testing. Environ. Mol. Mutagen. 25:1995;218-230.
3. Sofuni T., Suzuki T., Hayashi M. Initial consideration for use of transgenic mutation assays in a regulatory submission. Environ. Mol. Mutagen. 28:1996;443-446.
4. Erfle H.L., Walsh D.F., Holcroft J., Hague N., de Boer J.G., Glickman B.W. An efficient laboratory protocol for the sequencing of large numbers lacI mutants recovered from Big Blue transgenic animals. Environ. Mol. Mutagen. 28:1996;393-396.
5. Skopek T.R., Kort K.L., Marino D.R. Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1TM mice. Environ. Mol. Mutagen. 26:1995;9-15.
6. Zimmer D.M., Zhang X.B., Harbach P.R., Mayo J.K., Aaron C.S. Spontaneous an ethylnitrosourea-induced mutation fixation and molecular spectra at the lacI transgene in the Big Blue Rat-2 embryo cell line. Environ. Mol. Mutagen. 28:1996;325-333.
7. Dycaico M.J., Provost G.S., Kretz P.L., Ransom S.L., Moores J.C., Short J.M. The use of shuttle vectors for mutation analysis in transgenic mice and rats. Mutat. Res. 307:1994;461-478.
8. de Boer J.G. Software package for the management of sequencing projects using lacI transgenic animals. Environ. Mol. Mutagen. 25:1995;256-262.
9. Lundberg K.S., Provost G.S., Kretz P.L., Short J.M. The use of selection in recovery of transgenic targets for mutation analysis. Mutat. Res. 301:1993;99-105.
10. Heddle J.A., Tao K.S. The transmission rate of the lacI transgene from the Big Blue™ mouse. Mutat. Res. 348:1995;63-66.
11. Summers W.C., Glazer P.M., Malkevich D. Lambda phage shuttle vector for analysis of mutations in mammalian cells in cultures and in transgenic mice. Mutat. Res. 220:1989;263-268.
12. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Sorge J.A., Putman D.L., Short J.M. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 88:1991;7958-7962.
13. Tao K.S., Urlando C., Heddle J.A. Comparison of somatic mutation in a transgenic versus host locus. Proc. Natl. Acad. Sci. U. S. A. 90:1993;10681-10685.
14. Gossen J.A., de Leeuw W.J., Tan C.H., Zworthoff E.C., Berends F., Lohman P.H., Knook D.L., Vijg J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. U. S. A. 86:1989;7971-7975.
15. Nakahara W., Fukuoka F., Sugimura T. Carcinogenic action of 4-nitroquinoline-N-oxide. Gann. 48:1957;129-137.
16. Ruiz-Laguna J., Ariza R.R., Prieto-Alamo M.-J., Boiteux S., Pueyo C. Fpg protein protects E.coli K-12 from mutation induction by the carcinogen 4-nitroquinoline 1-oxide. Carcinogenesis. 15:1994;425-429.
17. Nagao M., Sugimura T. Molecular biology of the carcinogen, 4-nitroquinoline 1-oxide. Adv. Cancer Res. 23:1976;132-169.
18. Nunoshiba T., Demple B. Potent intracellular oxidative stress exerted by carcinogen 4-nitroquinoline-N-oxide. Cancer Res. 53:1993;3250-3252.
19. Fronza G., Campomenosi P., Iannone R., Abbondandolo A. The 4-nitroquinoline 1-oxide mutational spectrum in single-stranded DNA is characterized by guanine to pyrimidine transversions. Nucleic Acids Res. 20(6):1992;1283-1287.
20. Ryu J.-C., Youn J.-Y., Cho K.-H., Chang I.-M. Mutation spectrum in lacI gene of transgenic Big Blue cell line following to short term exposure 4-nitroquinoline N-oxide. Environ. Mol. Mutagen. 31(Suppl. 29):1998;16. 29th Environmental Mutagen Society, Anaheim, CA.
21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
22. Carmichael J., De Graff W.G., Gazdar A.F., Minna J.D., Mitchell J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47:1987;936-942.
23. Recio L. Transgenic Animal models and their application in mechanistically based toxicology research. CIIT Act. 15(10):1995.
24. G. Obe, A.T. Natarajan, Chromosomal Aberrations, Basic and Applied Aspects, pp. 266-269.
25. Provost G.S., Kretz P.L., Hamner R.T., Mattews C.D., Rogers B.J., Lundberg K.S., Dycaico M.J., Short J.M. Transgenic systems for in vivo mutation analysis. Mutat. Res. 288:1993;133-149.
26. Eller M.S., Ostrom K., Gilchrest B.A. DNA damage enhances melanogenesis. Proc Natl. Acad. Sci. U. S. A. 93:1996;1087-1092.
27. Manjanatha M.G., Chen J.B., Shaddock J.G. Jr., Harris A.J., Shelton S.D., Casciano D.A. Molecular analysis of lacI mutations in Rat2 cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation. Mutat. Res. 372:1996;53-64.
28. Wilson V.L., Smith R.A., Longoria J., Liotta M.A., Harper C.M., Harris C.C. Chemical carcinogen-induced decreases in genomic 5-methyldeoxycytidine content of normal human bronchial epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 84:1987;3298-3301.
29. Farrance I.K., Ivarie R. Ethylation of poly(dC-dG)poly(dC-dG) by ethyl methanesulfonate stimulates the activity of mammalian DNA methyltransferase in vitro. Proc. Natl. Acad. Sci. U. S. A. 82:1985;1045-1049.
30. Zingg J.-M., Jones P.A. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis. 18(5):1997;869-882.
31. Schmutte C., Yang A.S., Beart R.W., Jones P.A. Base excision repair of U:G mismatches at a mutational hotspot in the p53 gene is more efficient than base excision repair of T:G mismatches in extracts of human colon tumors. Cancer Res. 55:1995;3742-3746.
32. Spruck C.H., Rideout W.M., Olumi A.F., Ohneseit P.F., Yang A.S., Tsai Y.C., Nichols P.W., Horn T., Hermann G.G., Steven K. Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage. Cancer Res. 53:1993;1162-1166.
33. Puisieux A., Lim S., Groopman J., Ozturk M. Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res. 51:1991;6185-6189.
34. Biggs P.J., Warren W., Venitt S., Stratton M.R. Does a genotoxic carcinogen contribute to human breast cancer? The value of mutational spectra in unravelling the etiology of cancer. Mutagenesis. 8:1993;275-283.
35. Koch W.H., Henrikson E.N., Kupchella E., Cebula T.A. Salmonella typhimurium strain TA100 differentiates several classes of carcinogens and mutagens by base substitution specificity. Carcinogenesis. 15:1994;79-88.
36. Fronza G., Madzak C., Campomenosi P., Inga A., Iannone R., Abbondandolo A., Sarasin A. Mutation spectrum of 4-nitroquinoline 1-oxide-damaged single-stranded shuttle vector DNA transfected into monkey cells. Mutat. Res. 308:1994;117-125.
37. Inga A., Iannone R., Degan P., Campomenosi P., Fronza G., Abbondandolo A., Menichini P. Analysis of 4-nitroquinoline 1-oxide induced mutations at the hprt locus in mammalian cells: possible involvement of preferential DNA repair. Mutagenesis. 9:1994;67-72.
38. Daubersies P., Galiegue-Zouitina S., Koffel-Schwartz N., Fuchs R.P.P., Loucheux-Lefebvre M.-H., Bailleul B. Mutation spectra of the two guanine adducts of the carcinogen 4-nitroquinoline 1-oxide in Escherichia coli. Influence of neighbouring base sequence on mutagenesis. Carcinogenesis. 13:1992;349-354.
39. Watson D.E., Cunningham M., Tindall K.R. Spontaneous and ENU-induced mutation spectra at the cII locus in Big Blue® Rat2 embryonic fibroblasts. Mutagenesis. 13:1998;487-497.
40. Erexson G.L., Cunningham M.L., Tindall K.R. Cytogenetic characterization of the transgenic Big Blue® Rat2 and Big Blue® mouse embryonic fibroblast cell lines. Mutagenesis. 13:1998;649-656.