A randomised controlled trial investigating the effects of dopexamine on gastrointestinal function and organ dysfunction in the critically ill

Intensive Care Medicine

Volumn 28, Issue 7, 2002, Pages 884-890

  Ralph, Catherine J ^a   Tanser, Suzie J ^b   Macnaughton, Peter D ^b   Sinclair, David G ^a  

^a TORBAY HOSPITAL   (United Kingdom)

^b DERRIFORD HOSPITAL   (United Kingdom)

Author keywords

Dopexamine; Dual saccharide technique; Gastrointestinal permeability; Sequential Organ Failure Score

Indexed keywords

3 METHYLGLUCOSE; CREATININE; DOPEXAMINE; LACTULOSE; RHAMNOSE; DOPAMINE; DRUG DERIVATIVE;

ADULT; ARTICLE; CALCULATION; CHEMICAL ANALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE CLEARANCE; CRITICAL ILLNESS; DRUG EFFECT; DRUG INFUSION; FEMALE; HUMAN; INTENSIVE CARE UNIT; INTESTINE ABSORPTION; INTESTINE FUNCTION; INTESTINE MUCOSA PERMEABILITY; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESUSCITATION; SCORING SYSTEM; COMPARATIVE STUDY; DIGESTIVE SYSTEM; KIDNEY; MIDDLE AGED; PATHOPHYSIOLOGY; PERMEABILITY; TREATMENT OUTCOME; UNITED KINGDOM; URINE;

COMPARATIVE STUDY; CREATININE; CRITICAL ILLNESS; DOPAMINE; GASTROINTESTINAL SYSTEM; GREAT BRITAIN; HUMAN; INTESTINAL ABSORPTION; KIDNEY; MIDDLE AGE; PERMEABILITY; SUPPORT, NON-U.S. GOV'T; TREATMENT OUTCOME; DIGESTIVE SYSTEM; HUMANS; MIDDLE AGED;

EID: 0036020298     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-002-1322-6     Document Type: Article

References (39)

1. Multiple organ failure: The pilgrims progress
2. Evolving concepts in the pathogenesis of postinjury multiple organ failure
3. Splanchnic ischaemia and its role in multiple organ failure
4. The GI tract: The 'motor' of MOF
5. Regional blood flow responses to vasodilators and inotropes in congestive cardiac failure
6. An introduction to the pharmacologic properties of dopacard (dopexamine hydrochloride)
7. Gastrointestinal permeability following cardiopulmonary bypass: A randomised study comparing the effects of dopamine and dopexamine
8. Effects of dopexamine on creatinine clearance, systemic inflammation and splanchnic oxygenation in patients undergoing coronary artery bypass grafting
9. The effects of dobutamine, dopexamine and fluid on hepatic histological responses to porcine faecal peritonitis
10. Dopexamine hydrochloride maintains portal blood flow and attenuates hepatic ultrastructural changes in a porcine peritonitis model of multiple system organ failure
11. Pathogenesis on non-occlusive mesenteric ischaemia: Studies in a porcine model induced by pericardial tamponade
12. Ischaemic injury in the cat small intestine: The role of superoxide radicals
13. On the pathophysiology of intestinal ischaemic injury
14. Relationship of blood flow and oxygen consumption to ischaemic injury in the canine small intestine
15. Intestinal permeation of molecules in health and disease
16. Intestinal permeability is increased in burns patients shortly after injury
17. Intestinal permeability after severe trauma and haemorrhagic shock is increased without relation to septic complications
18. The effect of cardiopulmonary bypass upon intestinal and pulmonary endothelial permeability
19. Gastrointestinal permeability and absorptive capacity in sepsis
20. Increased intestinal permeability is associated with development of multiple organ dysfunction syndrome in critically ill ICU patients
21. Intestinal permeability: Functional assessment and significance
22. Effects of enteral and parenteral nutrition on gut mucosal permeability in the critically ill
23. The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study
24. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study
25. Abnormalities of gastric mucosal oxygenation in septic shock. Partial responsiveness to dopexamine
26. Dopexamine reduces the incidence of acute inflammation in the gut mucosa after abdominal surgery in the high-risk patients
27. A comparison of the effects of dopexamine and prostacyclin in systemic inflammatory response syndrome
28. Effects of dopaminergic agonists on organ blood flow and function
29. Regional blood flow and oxygen transport in low cardiac output syndrome after cardiac surgery
30. Gastric pH does not reflect change in splanchnic blood flow after cardiac surgery
31. Dopexamine increases splanchnic blood flow but decreases gastric mucosal pH in severe septic patients treated with dobutamine
32. A randomised clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients
33. Reducing the risk of major elective surgery: Randomised controlled trial of preoperative optimisation of oxygen delivery
34. Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure
35. Effect of dopexamine on outcome after major abdominal surgery: A prospective, randomised, controlled multicenter study
36. Effect of haemorrhagic shock on bacterial translocation, intestinal morphology and intestinal permeability in conventional and antibiotic-decontaminated rats
37. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: A randomised controlled trial
38. Intestinal permeability: An overview
39. Interpreting dual-sugar absorption studies in critically ill patients: What are the implications of apparent increases in intestinal permeability to hydrophilic solutes?