A comparison of the effects of dopexamine and prostacyclin in systemic inflammatory response syndrome

Anaesthesia

Volumn 54, Issue 4, 1999, Pages 313-319

  Blunt, M ^a   Young, P ^a   Ridley, S ^a  

^a NORFOLK AND NORWICH HOSPITAL   (United Kingdom)

Author keywords

Blood flow, splanchnic; Infection, systemic inflammatory response syndrome; Sympathetic nervous system, pharmacology, dopexamine

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DOPEXAMINE; PROSTACYCLIN;

ADRENERGIC SYSTEM; ADULT; AGED; ARTICLE; CARDIOVASCULAR FUNCTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HEART RATE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; OXYGEN TRANSPORT; RANDOMIZED CONTROLLED TRIAL; SPLANCHNIC BLOOD FLOW; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; URINE VOLUME;

ADRENERGIC BETA-AGONISTS; AGED; AGED, 80 AND OVER; ALGORITHMS; CROSS-OVER STUDIES; DOPAMINE; DOUBLE-BLIND METHOD; EPOPROSTENOL; HEMODYNAMIC PROCESSES; HUMANS; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; SPLANCHNIC CIRCULATION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; VASODILATOR AGENTS;

EID: 0032891137     PISSN: 00032409     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2044.1999.00748.x     Document Type: Article

References (28)

1. Deitch EA, Berg R, Specian R. Endotoxin promotes translocation of bacteria from the gut. Archives of Surgery 1987; 122: 185-90.
2. Fiddian-Green RG. Studies in splanchnic ischaemia and multiple organ failure. In: Marston A, Bulkley GB, Fiddian-Green RG, Haglund UH, eds. Splanchnic Ischaemia and Multiple Organ Failure. London: Edward Arnold, 1989; 349-63.
3. Fink MP. Gastrointestinal mucosal injury in experimental models of shock, trauma and sepsis. Critical Care Medicine 1991; 19: 627-41.
4. Meakins JL, Marshall JC. The gut as the motor of multiple system organ failure. In: Marston A, Bulkley GB, Fiddian-Green RG, Haglund UH, eds. Splanchnic Ischaemia and Multiple Organ Failure. London: Edward Arnold, 1989; 339-48.
5. Takala J, Roukonen E. Blood flow and oxygen transport in septic shock. Clinical Intensive Care 1992; 3 (Suppl.): 24-7.
6. Keller GA, West MA, Cerra FB, Simmons RL. Multiple systems organ failure. Modulation of hepatocyte protein synthesis by endotoxin-activated Kupffer cells. Annals of Surgery 1985; 201: 87-95.
7. Marshall JC, Lee C, Meakins JL, Michel RP, Christou NV. Kupffer cell modulation of the systemic immune response. Archives of Surgery 1987; 122: 191-6.
8. Maynard ND. Monitoring of gut and liver function in the critically ill. Clinical Intensive Care 1994; 5 (Suppl.): M23.
9. 2 uptake during endotoxaemia. Journal of Applied Physiology 1988; 64: 2410-19.
10. Fiddian-Green RG. Tonometry. Theory and application. Intensive Care World 1992; 9: 60-5.
11. Shelley MP. Grand round in intensive care. Clinical Intensive Care 1994; 5: 133-8.
12. Boyd O, Grounds M, Bennett ED. A randomised clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. Journal of the American Medical Association 1993; 270: 2699-707.
13. Young Y, Baldock D. Gastric intramural pH. Mixed venous lactate and dopexamine infusion. Clinical Intensive Care 1992; 3 (Suppl.): 40.
14. Tigne D, Moss RF, Haywood G, et al. Dopexamine hydrochloride maintains portal blood flow and attenuates hepatic ultrasound changes in a porcine peritonitis model of multiple system organ failure. Circulatory Shock 1993; 39: 199-206.
15. Leier CV. Regional blood flow responses to vasodilators and inotropes in congestive heart failure. American Journal of Cardiology 1988; 62: 86E-93E.
16. Differ H, Mattias FR, Voss R, Lohmann E. Beneficial effects of prostacyclin in a rabbit endotoxin shock model. Thrombosis Research 1988; 51: 403-15.
17. Bihari D, Smithies M, Gimson A, Tinker J. The effect of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients. New England Journal of Medicine 1987; 317: 397-403.
18. Bone RC, Balk RA, Cerra FB, et al. ACCP/SCCM Consensus Conference - definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 1992; 101: 1644-55.
19. Knaus WA, Draper EA, Wagner DP, Zimmerman JE, APACHE II. A severity of disease classification system. Critical Care Medicine 1985; 13: 818-29.
20. Maynard ND, Bihari DJ, Dalton RN, Smithies MN, Mason RC. Increasing splanchnic blood flow in the critically ill. Chest 1995; 108: 1648-54.
21. Fiddian-Green RG. Assessment of the adequacy of mucosal oxygenation in patients with intraluminally located silicone tonometers. In: Manabe H, Zweifach BW, Messmer K, eds. Microcirculation in Circulatory Disorder. Tokyo: Springer, 1988; 481-7.
22. Hills M, Armitage P. The two-period cross-over clinical trial. British Journal of Clinical Pharmacology 1979; 8: 7-20.
23. Bonde J, Lauritsen HK, Stenberg M, Kamp-Jensen M, Olsen NV. Low-dose dopamine in surgical and intensive care unit patients. Acta Anaesthesiologica Scandinavica 1996; 40: 326-30.
24. Webb AR, Moss RF, Tigne D, Al-Saady N, Bennett ED. The effect of dobutamine, dopexamine and fluid on hepatic histological responses to porcine faecal peritonitis. Intensive Care Medicine 1991; 17: 487-93.
25. Parviainen I, Ruokonen E, Takala J. Dobutamine-induced dissociation between changes in splanchnic blood flow and gastric intramucosal pH after cardiac surgery. British Journal of Anaesthesia 1995; 74: 277-82.
26. Smithies M, Hwei Yee T, Jackson L, Beale R, Bihari D. Protecting the gut and the liver in the critically ill: effects of dopexamine. Critical Care Medicine 1994; 22: 789-95.
27. Kuhly P, Oschmann G, Specht M, Spies C. Dopexamine hydrochloride does not improve gastric and sigmoid mucosal acidosis in patients with sepsis. British Journal of Anaesthesia 1995; 74 (Suppl. 1): A399.
28. Gutierrez G, Palizas F, Duglio G, et al. Gastric intramural pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992; 339: 195-9.