Reducing the risk of major elective surgery: Randomised controlled trial of preoperative optimisation of oxygen delivery

British Medical Journal

Volumn 318, Issue 7191, 1999, Pages 1099-1103

  Wilson, Jonathan ^a   Woods, Ian ^a   Fawcett, Jayne ^a   Whall, Rebecca ^a   Dibb, Wendy ^a   Morris, Chris ^a   McManus, Elizabeth ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; DOPEXAMINE; INOTROPIC AGENT; OXYGEN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ELECTIVE SURGERY; FLUID THERAPY; HOSPITALIZATION; HUMAN; OXYGEN SUPPLY; PATIENT MONITORING; POSTOPERATIVE COMPLICATION; PREOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK; TREATMENT OUTCOME;

EID: 0033599760     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.318.7191.1099     Document Type: Article

References (18)

1. 1 Campling EA, Devlin HB, Hoile RW, Lunn JN. National Confidential Enquiry into Perioperative Deaths. London: Royal College of Surgeons, 1992.
2. 2 Intensive Care National Audit and Research Centre. Annual report from the national case mix programme database. London: Intensive Care National Audit and Research Centre, 1998.
3. 3 Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee T. Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 1987;94:1176-86.
4. 4 Boyd O, Grounds RM, Bennett ED. A randomised clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 1993;270:2699-707.
5. 5 Mythen MG, Webb AR. The role of gut mucosal hypoperfusion in the pathogenesis of post-operative organ dysfunction. Intensive Care Med 1994;20:203-9.
6. 6 Brown RA, Dixon J, Farmer JB, Hall JC, Humphries RG, Ince F, et al. Dopexamine: a novel agonist at peripheral dopamine receptors and β-receptors. Br J Pharm 1985;85:599-608.
7. 7 Smithies M, Yee TH, Jackson L, Beale R, Bihari D. Protecting the gut and the liver in the critically ill: effects of dopexamine. Crit Care Med 1994;22:789-95.
8. 8 Meier-Hellmann A, Reinhart K, Bredle DL, Specht M, Spies CD, Hannemann L. Adrenaline impairs splanchnic perfusion in septic shock. Crit Care Med 1997;25:399-404.
9. 9 Copeland GP, Jones MW. POSSUM: a scoring system for surgical audit. Br J Surg 1991;78:355-60.
10. 10 Gardner MJ, Altman DG. Statistics with confidence, London: BMJ Books, 1989.
11. 11 Berlauk JF, Abrams JH, Gilmore IJ, O'Conner SR, Knighton DR, Cerra FB. Preoperative optimisation of cardiovascular hemodynamics improves outcome in peripheral vascular surgery. Ann Surg 1991;214:289-97.
12. 12 Copeland GP, Jones D, Wilcox A, Harris PL. Comparative vascular audit using the POSSUM scoring system. Ann R Coll Surg Engl 1993;75:175-7.
13. 13 Sagar PM, Hartley MN, Mancey-Jones B, Sedman PC, May J, Macfie J. Comparative audit of colorectal resection with the POSSUM scoring system. Br J Surg 1994;81:1492-4.
14. 14 Lugo G, Arizpe D, Dominguez G, Ramirez M, Tamariz O. Relationship between oxygen consumption and oxygen delivery during anesthesia in high-risk surgical patients. Crit Care Med 1993;21:64-9.
15. 15 Sinclair S, James S, Singer M. Intraoperative intravascular volume optimisation and length of stay after repair of proximal femoral fracture: randomised controlled trial. BMJ 1997;315:909-12.
16. 16 Mythen MG, Webb AR. Peroperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion in cardiac surgery. Arch Surg 1995;130:423-9.
17. 17 Erkens U, Scholz SE, Cordes T, Petzinger E, Hemplemann G. Dopexamine impairs hepatic cytokine secretion after stimulation by endotoxin via β-receptor. Intensive Care Med 1998;24:428S.
18. 18 Tighe D, Moss R, Bennett ED. Adrenergic receptor α1 agonist and β2 antagonist increase hepatic injury during sepsis. Intensive Care Med 1998;24:397S.