Detection of TOAD-64 in adult rat brain as revealed by two-dimensional protein gel electrophoresis followed by MALDI mass spectrometry: Possible modulatory effect of chronic haloperidol treatment

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 26, Issue 4, 2002, Pages 693-698

  Dahmen, Norbert ^a   Jungblut, Peter R ^b   Fischer, Viola ^a   Schrank, Martina ^a   Reuss, Stefan ^a   Rujescu, Dan ^a   Hiemke, Christoph ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

Gene expression; Haloperidol; Neuroleptics; TOAD 64

Indexed keywords

HALOPERIDOL; NERVE PROTEIN; BRAIN PROTEIN; PROTEIN TOAD 64; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMISTRY; CORPUS STRIATUM; DRUG EFFECT; FEMALE; FOREBRAIN; GENE EXPRESSION REGULATION; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; STATISTICS; TWO DIMENSIONAL GEL ELECTROPHORESIS; ANIMAL TISSUE; CONTROLLED STUDY; FETUS DEVELOPMENT; GENE EXPRESSION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR MECHANICS; NERVE CELL DIFFERENTIATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; ANIMALS; CORPUS STRIATUM; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; GENE EXPRESSION REGULATION; HALOPERIDOL; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; ANIMAL; SUPPORT, NON-U.S. GOV'T;

EID: 0036016288     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(01)00319-0     Document Type: Article

References (38)

1. Haloperidol-induced cell death mechanism and protection with vitamin E in vitro
2. Changes in dopamine D1, D2, D3 receptor mRNA levels in rat brain following antipsychotic treatment
3. Lack of effect of chronic antipsychotic treatment on dopamine D5 receptor mRNA level
4. Identification and molecular characterization of UNC-33-like phosphoprotein (ULIP), a putative mammalian homolog of the axonal guidance-associated unc-33 gene product
5. 2 sites
6. Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain
7. Dopamine receptor binding predicts clinical and pharmacological potencies of antipsychotic drugs
8. Induction of c-fos gene expression by the selective sigma receptor ligand EMD 57445 in rat brain
9. Chronical haloperidol treatment differentially affects the expression of synaptic and neuronal plasticity-associated genes
10. Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia
11. Effects of acute and chronic clozapine and haloperidol administration on 3-methoxytyramine accumulation in rat prefrontal cortex, nucleus accumbens and striatum
12. Treatment of tardive dyskinesia with vitamin E
13. Quantitative analysis of D2-dopamine receptor binding in the living human brain by PET
14. Two-dimensional database of mouse liver proteins. An update
15. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution
16. Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol
17. Initiation and adaptation: A paradigm for understanding psychotropic drug action
18. Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of IIL-60 leucemic cells
19. Protein composition of the human heart: The construction of a myocardial two-dimensional electrophoresis database
20. Two-dimensional electrophoresis of proteins: An updated protocol and implications for a functional analysis of the genome
21. Matrix-assisted laser desorption-ionization mass spectrometry peptide mass fingerprinting for proteome analysis: Identification efficiency after on-blot or in-gel digestion with and without desalting procedures
22. Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and Islands of Calleja
23. Effect of long-term haloperidol treatment on striatal neuropeptides: Relation to stereotyped behavior
24. Differential regulation of hippocampal AMPA and kainate receptor subunit expression by haloperidol and clozapine
25. TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth
26. Early postmitotic neurons transiently express TOAD-64, a neural specific protein
27. Neurotensin, antipsychotic drugs, and schizophrenia basic and clinical studies
28. Identification of human myocardial proteins separated by two-dimensional electrophoresis using an effective sample preparation for mass spectrometry
29. Neuroleptic-induced decrease in plasma homovanillic acid and antipsychotic activity in schizophrenic patients
30. Neuroleptics increase c-fos expression in the forebrain: Contrasting effects of haloperidol and clozapine
31. Induction pattern of fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity
32. Comparison of two-dimensional electrophoresis patterns of heat shock protein Hsp27 species in normal and cardiomyopathic hearts
33. Identification and characterization of heat shock protein 27 protein species in human myocardial 2-DE patterns
34. Chronic haloperidol and clozapine in rats: A behavioral analysis
35. Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4
36. A family of rat CRMP genes is differentially expressed in the nervous system
37. Haloperidol and apomorphine differentially affect neuropeptidase activity
38. Negative symptoms and hypofrontality in chronic schizophrenia