Evaluation of plasma time-activity curves of technetium-99m-mebrofenin for measurement of hepatic function in dogs

Veterinary Radiology and Ultrasound

Volumn 41, Issue 1, 2000, Pages 78-84

  Matwichuk, Cary L ^a,b   Daniel, Gregory B ^a   Denovo, Robert C ^a   Schultze, A Eric ^a   Schmidt, Dorothy E ^a   Creevy, Kate E ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b Dept of Small Anim Clin Sciences ^*  (United States)

Author keywords

99mTc mebrofenin; Hepatocellular function; Plasma clearance

Indexed keywords

CANIS FAMILIARIS;

ANTIFILARIAL AGENT; CARBON TETRACHLORIDE; DIAGNOSTIC AGENT; IMINO ACID; RADIOPHARMACEUTICAL AGENT; SOLVENT; TECHNETIUM COMPLEX; TECHNETIUM TC 99M MEBROFENIN; THIACETARSAMIDE;

ALGORITHM; ANIMAL; ANIMAL DISEASE; AREA UNDER THE CURVE; ARTICLE; BLOOD; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOG; DOG DISEASE; DRUG EFFECT; FOLLOW UP; INTRAVENOUS DRUG ADMINISTRATION; LIVER; LIVER DISEASE; MESENTERIC VEIN; METABOLISM; PHYSIOLOGY; SCINTISCANNING; STATISTICAL MODEL;

ALGORITHMS; ANIMALS; AREA UNDER CURVE; ARSENAMIDE; CARBON TETRACHLORIDE; DOG DISEASES; DOGS; FILARICIDES; FOLLOW-UP STUDIES; IMINO ACIDS; INJECTIONS, INTRAVENOUS; LINEAR MODELS; LIVER; LIVER DISEASES; MESENTERIC VEINS; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; SOLVENTS;

EID: 0033632083     PISSN: 10588183     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1740-8261.2000.tb00431.x     Document Type: Article

References (13)

1. Krishnamurthy GT, Turner FE. Pharmacokinetics and Clinical Application of Technetium-99m-Labeled Hepatobiliary Agents. Semin Nucl Med 1990;20:130-149.
2. Doo E, Krishnamurthy GT, Eklem MJ, Gilbert S, Brown PH. Quantification of Hepatobiliary Function as an Integral Part of Imaging with Technetium-99m-Mebrofenin in Health and Disease. J Nucl Med 1991; 323:48-57.
3. Brown PH, Juni JE, Lieberman DA, Krishnamurthy GT. Hepatocyte Versus Biliary Disease: A Distinction by Deconvolutional Analysis of Technetium-99m IDA Time-Activity Curves. J Nucl Med 1988;29:623-630.
4. Lieberman DA, Brown PH, Krishnamurthy GT. Improved Scintigraphic Assessment of Severe Cholestasis with the Hepatic Extraction Fraction. Digestive Diseases and Sciences 1990;35:1385-1390.
5. Juni JE, Reichle R. Measurement of Hepatocellular Function with Deconvolutional Analysis: Application in the Differential Diagnosis of Acute Jaundice. Radiology 1990;177:171-175.
6. Daniel GB, Bahr A, Dykes JA, DeNovo R, Young K, Smith GT. Hepatic Extraction Efficiency and Excretion Rate of Technetium-99m-Mebrofenin in Dogs. J Nucl Med 1996;37:1846-1849.
7. Chilton HM, Witcofski RL. Radiopharmaceuticals for Gastrointestinal Imaging. In: Chilton HM, Witcofski RL (eds). Nuclear Pharmacy: An Introduction to the Clinical Application of Radiopharmaceuticals. Philadelphia: Lea & Febiger, 1986.
8. Center SA. Pathophysiology and Laboratory Diagnosis of Hepatobiliary Disorders. In: Ettinger SJ, Feldman EC (eds). Textbook of Veterinary Internal Medicine. Fourth Edition. Philadelphia: W.B. Saunders Company, 1995.
9. Bahr A, Daniel GB, DeNovo R, Young K, Merryman JL. Quantitative Hepatobiliary Scintigraphy with Deconvolutional Analysis for the Measurement of Hepatic Function in Dogs. Vet Radiol Ultrasound 1996; 37:214-220.
10. Newell SM, Selcer BA, Roberts RE, et al. Use of hepatobiliary scintigraphy in clinically normal cats. Am J Vet Res 1994;55:762-768.
11. Newell SM, Selcer BA, Roberts RE, Cornelius LM, Mahaffey EA. Hepatobiliary Scintigraphy in the Evaluation of Feline Liver Disease. J Vet Intern Med 1996;10:308-315.
12. Daniel GB, DeNovo RC, Schultze AE, Schmidt D, Smith GT. Hepatic Extraction Efficiency of Technetium-99m-Mebrofenin in the Dog with Toxic-Induced Acute Liver Disease. J Nucl Med 1998;39:1286-1292.
13. Shargel L, Yu BCA. Bioavailability and Bioequivalence. In: Shargel L, Yu BCA (eds). Applied Biopharmaceutics and Pharmacokinetics, 3rd ed. East Norwalk: Appleton & Lange, 1993.