The human genetics of eating disorders: Lessons from the leptin/melanocortin system

Child and Adolescent Psychiatric Clinics of North America

Volumn 11, Issue 2, 2002, Pages 387-397

  Costa, Jessica Lynn ^a   Brennen, Miles B ^a,b   Hochgeschwender, Ute ^c  

^a UNIVERSITY OF DENVER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN; ALPHA INTERMEDIN; ASPARTIC PROTEINASE; CORTICOTROPIN RECEPTOR; SERINE PROTEINASE;

BODY MASS; CULTURAL FACTOR; DIET RESTRICTION; EATING DISORDER; EXERCISE; GENE MUTATION; GENETICS; HUMAN; MALNUTRITION; OBESITY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; WEIGHT GAIN; ADOLESCENT; ANOREXIA NERVOSA; BULIMIA; CHILD; ENERGY METABOLISM; GENOTYPE; INFANT; PRESCHOOL CHILD; TWINS;

ADOLESCENT; ALPHA-MSH; ANOREXIA NERVOSA; ASPARTIC ENDOPEPTIDASES; BULIMIA; CHILD; CHILD, PRESCHOOL; ENERGY METABOLISM; GENOTYPE; HUMAN; INFANT; LEPTIN; OBESITY; PHENOTYPE; RECEPTORS, CORTICOTROPIN; SUPPORT, NON-U.S. GOV'T; TWIN STUDIES; HUMANS; PROPROTEIN CONVERTASES; RECEPTOR, MELANOCORTIN, TYPE 4;

EID: 0035998981     PISSN: 10564993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-4993(01)00013-X     Document Type: Review

References (60)

1. Cultural and historical aspects of eating disorders
2. The relationship of obsessive-compulsive disorder to possible spectrum disorders: Results from a family study
3. Lack of association between anorexia nervosa and D3 dopamine receptor gene
4. Reduced plasma leptin concentrations in bulimia nervosa
5. Eating disorders and antecedent anxiety disorders: A controlled study
6. Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder
7. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
8. Association between a marker in the CUP-2/UCP-3 gene cluster and genetic susceptibility to anorexia nervosa
9. Lack of association between 5-HT2A gene promoter polymorphism and susceptibility to anorexia nervosa
10. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
11. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
12. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
13. Association between 5-HT2A gene promoter polymorphism and anorexia nervosa
14. 5-HT2A promoter polymorphism - 1438G/A, anorexia nervosa, and obsessive-compulsive disorder
15. History of eating disorders in female patients with obsessive-compulsive disorder
16. Twin studies and the etiology of eating disorders
17. Effects of recombinant leptin therapy in a child with congenital leptin deficiency
18. Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non-specific eating disorders correlate with the body mass index but are independent of the respective disease
19. Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway
20. Association of anorexia nervosa with the high activity allele of the COMT gene. A family-based study in Israeli patients
21. Association of a functional 5-HT transporter gene polymorphism with anorexia nervosa and food intake
22. Comorbidity of psychiatric diagnoses in anorexia nervosa
23. Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
24. Serotonin transporter gene-linked polymorphic region: Allele distribution in relationship to body weight and in anorexia nervosa
25. Systematic mutation screening of the pro-opiomelanocortin gene: Identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes
26. No evidence of involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: Identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region
27. No evidence for an involvement of alleles of polymorphisms in the serotonin1Dbeta and 7 receptor genes in obesity, underweight or anorexia nervosa
28. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
29. No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity
30. 5-HT2A receptor gene polymorphisms, anorexia nervosa, and obesity
31. Diabetes, a new mutation in the mouse
32. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
33. Eating disorder and obsessive-compulsive disorder: Neurohemical and phenomenological commonalities
34. Anorexia nervosa, obsessional behavior, and serotonin
35. Anorexia and bulimia nervosa
36. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
37. Abnormal splicing of the leptin receptor in diabetic mice
38. Comorbidity of obsessive compulsive disorder in patients with eating disorders
39. Evolution of a Cys23Ser mutation within the human 5-HT2C receptor gene: No evidence for an association of the mutant allele with obesity or underweight in children, adolescents and young adults
40. Prevalence and symptomatology of comorbid obsessive-compulsive disorder among bulimic patients
41. Congenital leptin deficiency is associated with severe early-onset obesity in humans
42. 5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa
43. Screening for mutations in the neuropeptide YY5 receptor gene in cohorts belonging to different weight extremes
44. Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: Identification of several genetic variants
45. A preliminary investigation of the lifetime prevalence of anorexia and bulimia nervosa in patients with obsessive compulsive disorder
46. 5-HT2A promoter polymorphism in anorexia nervosa
47. A leptin missense mutation associated with hypogonadism and morbid obesity
48. Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa
49. Eating disorder history in women with obsessive compulsive disorder
50. Obsessive-compulsive disorder among patients with anorexia nervosa and bulimia nervosa
51. Obsessive compulsive comorbidity in the dieting disorders
52. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
53. Association between an agouti-related protein gene polymophism and anorexia nervosa
54. Obesity in the mouse model of proopiomelanocortin deficiency responds to peripheral melanocortin
55. A frameshift mutation in MC4R associated with dominantly inherited human obesity
56. Further lack of association between the 5-HT2A gene promoter polymorphism and susceptibility to eating disorders and a meta-analysis pertaining to anorexia nervosa