Reactivity toward thiols and cytotoxicity of 3-methylene-2-oxindoles, cytotoxins from indole-3-acetic acids, on activation by peroxidases

Chemical Research in Toxicology

Volumn 15, Issue 6, 2002, Pages 877-882

  Folkes, Lisa K ^a   Rossiter, Sharon ^a   Wardman, Peter ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLENE 2 OXINDOLE DERIVATIVE; CHLORINE; CYSTEINE; CYTOTOXIN; FLUORINE; GLUTATHIONE; HALOGEN; HORSERADISH PEROXIDASE; INDOLEACETIC ACID; METHYL GROUP; OXINDOLE; PEPTIDE; PEROXIDASE; PRODRUG; THIOL DERIVATIVE; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; INDOLEACETIC ACID DERIVATIVE; METHANOL;

ANIMAL CELL; ARTICLE; CANCER THERAPY; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; CYTOTOXICITY; DIFFUSION; DRUG ACTIVATION; DRUG SYNTHESIS; DRUG TARGETING; NONHUMAN; OXIDATION; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION; ANIMAL; BIOTRANSFORMATION; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; CRICETULUS; CYTOLOGY; DRUG EFFECT; FIBROBLAST; HAMSTER; KINETICS; LUNG; METABOLISM; OXIDATION REDUCTION REACTION;

ANIMAL; BIOTRANSFORMATION; CELL SURVIVAL; CELLS, CULTURED; COMPARATIVE STUDY; CRICETULUS; CYSTEINE; CYTOTOXINS; FIBROBLASTS; GLUTATHIONE; HAMSTERS; HORSERADISH PEROXIDASE; INDOLEACETIC ACIDS; INDOLES; KINETICS; LUNG; METHANOL; OXIDATION-REDUCTION; PEPTIDES; PRODRUGS; SULFHYDRYL COMPOUNDS; SUPPORT, NON-U.S. GOV'T; ANIMALS; CRICETINAE;

ANIMALIA; ARMORACIA RUSTICANA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0035998288     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx025521+     Document Type: Article

References (46)

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