lkB kinase alpha: A link in the chain of the mammary cycle

Breast Cancer Research

Volumn 4, Issue 5, 2002, Pages 173-175

  Clarkson, Richard ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apoptosis; lkB kinase; Mammary; NF B; Proliferation

Indexed keywords

CYCLIN D1; I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; CHUK PROTEIN, HUMAN; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST DEVELOPMENT; CARCINOGENESIS; CELL FATE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME SPECIFICITY; EPITHELIUM CELL; GENE ACTIVITY; HUMAN; HUMAN CELL; INVOLUTION; LACTATION; MAMMARY GLAND; MOUSE; MOUSE MUTANT; NONHUMAN; PREGNANCY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; BREAST; BREAST TUMOR; CELL DIVISION; ENZYMOLOGY; FEMALE; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; BREAST; BREAST NEOPLASMS; CELL DIVISION; EPITHELIAL CELLS; FEMALE; HUMANS; I-KAPPA B KINASE; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 0035995597     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr446     Document Type: Article

References (22)

1. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
2. NF-κB inhibits apoptosis in murine mammary epithelia
3. Activation of NF-kappaB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated beta-casein gene expression
4. The NF-kappa B activation pathway: A paradigm in information transfer from membrane to nucleus
5. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
6. Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium
7. Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
8. Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
9. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
10. IKKalpha controls formation of the epidermis independently of NF-kappaB
11. Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice
12. NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts
13. Roles of Fas and Fas ligand during mammary gland remodeling
14. NF-kappaB and apoptosis in mammary epithelial cells
15. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
16. Suppression of TNF-alpha-induced apoptosis by NF-kappaB
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18. Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
19. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer
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21. Specific protection against breast cancers by cyclin D1 ablation
22. Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis