Infusion of pregnant rats with calcitonin gene-related peptide (CGRP)8-37, a CGRP receptor antagonist, increases blood pressure and fetal mortality and decreases fetal growth

Biology of Reproduction

Volumn 67, Issue 2, 2002, Pages 624-629

  Gangula, P R R ^a   Dong, Y L ^a   Wimalawansa, S J ^a   Yallampalli, C ^a  

^a Medical Research Building ^*  (United States)

Author keywords

Placenta; Pregnancy; Progesterone; Uterus

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[8-37]; PROGESTERONE; RECEPTOR BLOCKING AGENT; CALCITONIN GENE RELATED PEPTIDE (8 37); CALCITONIN GENE-RELATED PEPTIDE (8-37); PEPTIDE FRAGMENT;

ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; DOSE RESPONSE; FEMALE; FETUS; FETUS GROWTH; FETUS MORTALITY; FETUS WEIGHT; HORMONE ACTION; NONHUMAN; PLACENTA DEVELOPMENT; PREGNANCY; PRIORITY JOURNAL; PUERPERIUM; RAT; SYSTOLIC BLOOD PRESSURE; ANIMAL; BIRTH WEIGHT; BLOOD FLOW; BREEDING; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; FETUS DEATH; GROWTH, DEVELOPMENT AND AGING; ORGAN SIZE; PHYSIOLOGY; PLACENTA; PRENATAL DEVELOPMENT; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; BIRTH WEIGHT; BLOOD PRESSURE; CALCITONIN GENE-RELATED PEPTIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL DEATH; FETAL WEIGHT; ORGAN SIZE; PEPTIDE FRAGMENTS; PLACENTA; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY, ANIMAL; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; REGIONAL BLOOD FLOW;

EID: 0035992903     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod67.2.624     Document Type: Article

References (45)

1. Calcitonin gene-related peptide and its receptors: Molecular genetics, physiology, pathophysiology and therapeutic potentials
2. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
3. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and eight other species
4. Ontogeny of peptide and amino-containing neurons in motor, sensory and autonomic regions of rat and human spinal cord, dorsal root ganglia and rat skin
5. The origin of circulating calcitonin gene-related peptide in the rat
6. Dose-dependent systemic and regional hemodynamic effects of calcitonin generelated peptide
7. Cardiovascular actions of calcitonin gene-related peptide
8. Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation
9. Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: Implications for atherosclerosis
10. Effects of acute and chronic estrogen treatment on vasomotor responses of aortic rings from ovariectomized rats
11. Natural progesterone and antihypertensive action
12. Pregnancy and steroid hormones enhance the vasodilation responses to CGRP in rats
13. Pregnancy and steroid hormones enhance the systemic and regional hemodynamic effects of calcitonin gene-related peptide (CGRP) in rats
14. Calcitonin gene-related peptide is a depressor in NG-nitro-L-arginine methyl ester-induced hypertension during pregnancy
15. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia and intrauterine growth retardation
16. CGRP reverses the hypertension and significantly decreases the fetal mortality in preeclampsia rats induced by nitro-L-arginine methyl ester
17. Pregnancy related hypertension
18. Maternal cardiovascular and other physiologic responses to the endocrinology of pregnancy
19. Effects of calcitonin gene-related peptide on vascular resistance in rats: Role of sex steroids
20. Effect of calcitonin gene-related peptide on the uterine vasculature of the nonpregnant ewe
21. Possible physiologic role of calcitonin gene-related peptide in the human uterine artery
22. Relaxation by calcitonin gene-related peptide may involve activation of K+ channels in the human uterine artery
23. Human a- and b-calcitonin gene-related peptides are vasodilators in human chorionic plate vasculature
24. Vasodilator effects of parathyroid hormone, parathyroid hormone-related protein and calcitonin gene-related peptide in the human fetal-placental circulation
25. Hormone profiles for progesterone, oestradiol, prolactin, plasma renin activity, aldosterone and corticosterone during pregnancy and pseudopregnancy in two strains of rat: Correlation with renal studies
26. Maternal hemodynamics and uteroplacental blood flow throughout gestation in conscious rats
27. Progesterone upregulates vasodilator effects of calcitonin gene-related peptide in NG-nitro-L-arginine methyl ester-induced hypertension
28. Increased concentration of circulating calcitonin gene-related peptide during normal human pregnancy
29. Hormonal influence on CGRP in man: Effect of sex difference and contraceptive pills
30. Pregnancy and sex steroid hormones enhance circulating calcitonin gene-related peptide levels in rats
31. Characterization of CGRP1 and CGRP2 receptor subtypes
32. Involvement of multiple receptors in the biological effects of calcitonin gene-related peptide and amylin in rat and guinea-pig preparations
33. Pharmacological characterization of CGRP receptor subtype in the vascular system of the rat: Studies with hCGRP fragments and analogues
34. Human alpha-calcitonin gene-related peptide (CGRP)-(8-37), but not-(28-37), inhibits carotid vasodilator effect of human alpha-CGRP in vivo
35. Antagonistic effects of human alpha-CGRP [8-37] on the in vivo regional haemodynamic actions of human alpha-CGRP
36. 8-37) inhibits microvascular response induced by CGRP and capsaicin in skin
37. Regulation of vascular adaptation during pregnancy and postpartum: Effects of nitric oxide inhibition and steroid hormones
38. Regulation of calcitonin gene-related peptide receptors in the rat uterus during pregnancy, labor and by progesterone
39. Regulation of calcitonin gene-related peptide (CGRP) receptors in nonpregnant and pregnant rat mesenteric arteries and by sex steroid hormones
40. Mechanisms involved in calcitonin gene-related peptide-induced relaxation and expression of CGRP receptor components in pregnant rat uterine artery
41. Calcitonin gene-related peptide receptor in human placental syncytiotrophoblast brush-border and basal plasma membranes
42. Uterine relaxation responses to calcitonin gene-related peptide and calcitonin gene-related peptide receptors decreased during labor in rats
43. Involvement of calcitonin gene-related peptide in the modulation of human myometrial contraction during pregnancy
44. Differential sensitivity of human nonpregnant and pregnant myometrium to calcitonin gene-related peptide
45. Endocrine and paracrine regulation of birth at term and preterm