Of mice and men: The tale of two therapies

Stem Cells

Volumn 20, Issue 4, 2002, Pages 275-278

  Hawley, Robert G ^a   Sobieski, Donna A ^b  

^a Holland Laboratory   (United States)

^b AMERICAN RED CROSS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; CD34 ANTIGEN; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN; MACROGOL; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; RAG2 PROTEIN; CYTOKINE RECEPTOR;

ALLOTRANSPLANTATION; BONE MARROW TRANSPLANTATION; CELL CULTURE; CELL LINEAGE; CELLULAR IMMUNITY; COMBINED IMMUNODEFICIENCY; DNA VECTOR; DRUG FORMULATION; ENZYME REPLACEMENT; FOLLOW UP; GENE THERAPY; GENETIC CODE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IN SITU HYBRIDIZATION; MOLECULAR CLONING; NATURAL KILLER CELL; NONHUMAN; POLYMERASE CHAIN REACTION; SHORT SURVEY; STEM CELL; T LYMPHOCYTE; TREATMENT OUTCOME; ANIMAL; CELL NUCLEUS; CELL NUCLEUS TRANSPLANTATION; CLONING; CYTOLOGY; DISEASE MODEL; GENETIC ENGINEERING; GENETICS; HEMATOPOIETIC STEM CELL; IMMUNOLOGY; METHODOLOGY; MOUSE; REVIEW;

ANIMALS; CELL NUCLEUS; CLONING, ORGANISM; DISEASE MODELS, ANIMAL; GENE THERAPY; GENETIC ENGINEERING; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; NUCLEAR TRANSFER TECHNIQUES; RECEPTORS, CYTOKINE; SEVERE COMBINED IMMUNODEFICIENCY; T-LYMPHOCYTES;

EID: 0035991657     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.20-4-275     Document Type: Short Survey

References (21)

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2. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
3. Detection of pluripotent hematopoietic cells in SCID-X1 gene therapy
4. Long-term immune reconstitution and outcome after HLA-nonidentical T-cell-depleted bone marrow transplantation for severe combined immunodeficiency: A European retrospective study of 116 patients
5. Successful treatment of human X-SCID using a GALV-pseudotyped retroviral vector
6. +CD38-cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function
7. Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells
8. Expression levels by retroviral vectors based upon the N2 and the MFG backbones
9. Correction of ADA-SCID by stem cell gene therapy combined with non-myeloablative conditioning
10. Successful peripheral T-lymphocyte-directed gene transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency
11. Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement
12. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy
13. RAG and RAG defects
14. Hematopoietic commitment during embryonic stem cell differentiation in culture
15. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic precursors
16. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
17. Intraembryonic, but not yolk sac hematopoietic precursors, isolated before circulation, provide long-term multilineage reconstitution
18. Neurotrophic activity of the Antennapedia homeodomain depends on its specific DNA-binding properties
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21. Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse