Overexpression of HOX11 leads to the immortalization of embryonic precursors with both primitive and definitive hematopoietic potential

Blood

Volumn 92, Issue 3, 1998, Pages 877-887

  Keller, Gordon ^a   Wall, Charles ^b   Fong, Andrew Z C ^b   Hawley, Teresa S ^b   Hawley, Robert G ^b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; ERYTHROPOIESIS; GENE EXPRESSION; GROWTH REGULATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

EID: 0032147039     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.3.877     Document Type: Article

References (57)

1. Russell E: Heriditary anemias of the mouse: A review for geneticists. Adv Genet 20:357, 1979
2. Moore M, Metcalf D: Ontogeny of the hematopoietic system: Yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br J Haematol 18:279, 1970
3. Barker J: Development of the mouse hematopoietic system I. Types of hemoglobin produced in embryonic yolk sac and liver. Dev Biol 18:14, 1968
4. Brotherton T, Chui D, Gauldie J, Patterson M: Hemoglobin ontogeny during normal mouse fetal development. Proc Natl Acad Sci USA 76:2853, 1979
5. Johnson G, Barker D: Erythroid progenitor cells and stimulating factors during murine embryonic and fetal development. Exp Hematol 13:200, 1985
6. Godin I, Dieterlen-Lievre F, Cumano A: Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus. Proc Natl Acad Sci USA 92:773, 1995
7. Muller AM, Medvinsky A, Strouboulis J, Grosveld F, Dzierzak E: Development of hematopoietic stem cell activity in the mouse embryo. Immunity 1:291, 1994
8. Mucenski M, McLain K, Kier A, Swerdlow S, Schreiner C, Miller T, Pietryga D, Scott JW, Potter S: A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65:677, 1991
9. Okuda T, Van Deursen J, Hiebert S, Grosveld G, Downing JR: AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321, 1996
10. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe A, Speck N: Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 93:3444, 1996
11. Nocka K, Majumder S, Chabot B, Ray P, Cervone M, Bernstein A, Besmer P: Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice-evidence for an impaired c-kit kinase in mutant mice. Genes Dev 3:816, 1989
12. Wu H, Liu X, Jaenisch R, Lodish H: Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83:59, 1995
13. Lin C, Lim S, DAgati V, Costantini F: Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev 10:154, 1996
14. Wong P, Chung S, Chui D, Eaves C: Properties of the earliest clonogenic hemopoietic precursor to appear in the developing murine yolk sac. Proc Natl Acad Sci USA 83:3851, 1986
15. Keller G, Kennedy M, Papayannopoulou T, Wiles M: Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol 13:473, 1993
16. Schmitt R, Bruyns E, Snodgrass H: Hematopoietic development of embryonic stem cells in vitro: Cytokine and receptor gene expression. Genes Dev 5:728, 1991
17. Burkert U, von Ruden T, Wagner EF: Early fetal hematopoietic development from in vitro differentiated embryonic stem cells. New Biol 3:698, 1991
18. Keller G: In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol 7:862, 1995
19. Kabrun N, Buhring HJ, Choi K, Ullrich A, Risau W, Keller G: Flk-I expression defines a population of early embryonic hematopoietic precursors. Development 124:2039, 1997
20. Hawley RG, Fong AZC Lu M, Hawley TS: The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors, Oncogene 9:1, 1994
21. Perkins AC, Cory S: Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene. EMBO J 12:3835, 1993
22. Sauvageau G, Thorsteinsdottir U, Eaves C, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK: Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9:1753, 1995
23. Helgason CD, Sauvageau G, Lawrence HJ, Largman C, Humphries RK: Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cell differentiated in vitro. Blood 87:2740, 1996
24. Hawley RG, Lieu FHL, Fong AZC, Hawley TS: Versatile retroviral vectors for potential use in gene therapy. Gen Ther 1:136, 1994
25. Hawley RG, Hawley TS, Fong AZC, Quinto C, Collins M, Leonard JP, Goldman SJ: Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin-11. Proc Natl Acad Sci USA 93:10297, 1996
26. Hawley TS, Sabourin LA, Hawley RG: Comparative analysis of retroviral vector expression in mouse embyonal carcinoma cells. Plasmid 22:120, 1989
27. Brady G, Barbara M, Iscove N: Representative in vitro cDNA amplification from individual hemopoietic cells and colonies. Methods Mol Cell Biol 2:17, 1990
28. Church GM, Gilbert W: Genomic sequencing. Proc Natl Acad Sci USA 81:1991, 1984
29. Karasuyama H, Melchers F: Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4, or 5 using modified cDNA expression vectors. Eur J Immunol 18:97, 1988
30. Hawley RG, Fong AZC, Reis MD, Zhang N, Lu M, Hawley TS: Transforming function of the HOX11/TCL3 homeobox gene. Cancer Res 57:337, 1997
31. Rodewald H-R, Moingeon P, Lucich J, Dosiou C, Lopez P, Reinherz E: A population of early fetal thymocytes expressing FcγRII/ III contains precursors of T lymphocytes and natural killer cells. Cell 69:139, 1992
32. Carlsson L, Candeias S, Staerz U, Keller G: Expression of FcγRIII defines distinct subpopulations of fetal liver B cell and myeloid precursors. Eur J Immunol 25:2308, 1995
33. Miyake K, Medina KL, Hayashi S, Ono S, Hamaoka T, Kincade PW: Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures. J Exp Med 171:477, 1990
34. Hemler ME: VLA proteins in the integrin family: Structures, functions, and their role on leukocytes. Annu Rev Immunol 8:365, 1990
35. Miller BA, Antognetti G, Springer TA: Identification of cell surface antigens present on murine hematopoietic stem cells. J Immunol 134:3286, 1985
36. Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chien Y-H, Weissman IL: A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 62:863, 1990
37. Jordan C, McKearn J, Lemischka I: Cellular and developmental properties of fetal hematopoietic stem cells. Cell 61:953, 1990
38. Spangrude G, Heimfeld S, Weissman I: Purification and characterization of mouse hematopoeitic stem cells. Science 241:58, 1988
39. Morrison SJ, Hemmati HD, Wandycz AM, Weissman IL: The purification and characterization of fetal liver hematopoietic stem cells. Proc Natl Acad Sci USA 92:10302, 1995
40. Trevisan M, Iscove NN: Phenotypic analysis of murine long-term hemopoietic reconstituting cells quantitated competitively in vivo and comparison with more advanced colony-forming progeny. J Exp Med 181:93, 1995
41. Hestday K, Ruscetti FW, Ihle JN, Jacobsen SEW, Dubois CM, Kopp WC, Longo DL, Keller JR: Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. J Immunol 147:22, 1991
42. Coffman RL, Weissman IL: A monoclonal antibody that recognizes B cells and B cell precursors in mice. J Exp Med 153:269, 1981
43. Owczarek C, Layton M, Robb L, Nicola N, Begley CG: Molecular basis of the soluble and membrane-bound forms of the murine leukemia inhibitory factor receptor alpha-chain. J Biol Chem 271:5495, 1996
44. Begley CG, Aplan PD, Denning S, Haynes BF, Waldmann TA, Kirsch SS: The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proc Natl Acad Sci USA 86:10128, 1989
45. Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey RP, Metcalf D, Begley CG: Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci USA 92:7075, 1995
46. Shivdasani R, Mayer E, Orkin SH: Absence of blood formation in mice lacking the T-cell leukemia oncoprotein tal-1/SCL. Nature 373:432, 1995
47. Orkin S: GATA-binding transcription factors in hematopoietic cells. Blood 80:575, 1992
48. Dieterlen-Lievre F: On the origin of haemopoietic stem cells in the avian embryo: An experimental approach. J Embryol Exp Morph 33:607, 1975
49. Lassila O, Martin C, Toivanen P, Dieterlen-Lievre F: Erythropoiesis and lymphopoiesis in the chick yolk-sac-embryo chimeras: Contribution of yolk sac and intraembryonic stem cells. Blood 59:377, 1982
50. Cumano A, Dieterlen-LIevre F, Godin I: Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. Cell 86:907, 1996
51. Nakano T, Kodama H, Honjo T: In vitro development of primitive and definitive erythrocytes from different precursors. Science 272:722, 1996
52. Kennedy M, Firpo M, Choi K, Wall C, Robertson S, Kabrun N, Keller G: A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature 386:488, 1997
53. Turpen JB, Kelly CM, Mead PE, Zon LI: Bipotential primitive-definitive hematopoietic progenitors in the vertebrate embryo. Immunity 7:325, 1997
54. Stewart CL, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Kontgen F, Abbondanzo SJ: Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 359:76, 1992
55. Escary J-L, Perreau I, Dumenil D, Ezine S, Brulet P: Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature 363:361, 1993
56. Yoshida K, Taga T, Saito M, Suematsu S, Kumanogoh A, Tanaka T, Fujiwara H, Hirata M, Yamagami T, Nakahata T, Hirabayashi T, Yoneda Y, Tanaka K, Wang WZ, Mori C, Shiota K, Yoshida N, Kishimoto T: Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci USA 93:407, 1996
57. Kawabe T, Muslin AJ, Korsmeyer SJ: HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. Nature 385:454, 1997