Searching for the cartilage-associated mimicry epitope in adjuvant arthritis

Autoimmunity

Volumn 35, Issue 3, 2002, Pages 201-210

  Van Bilsen, Jolanda H M ^a   Wagenaar Hilbers, Josée P A ^a   Boot, Elmieke P J ^a   Van Eden, Willem ^a   Wauben, Marca H M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Adjuvant arthritis; Molecular mimicry; Mycobacterium tuberculosis; T cell epitopes

Indexed keywords

ANTIGEN; EPITOPE; FREUND ADJUVANT; HEAT SHOCK PROTEIN 65; AUTOANTIGEN; BACTERIAL PROTEIN; CHAPERONIN; HEAT SHOCK PROTEIN 65, MYCOBACTERIUM; HEAT-SHOCK PROTEIN 65, MYCOBACTERIUM; PEPTIDE FRAGMENT; STROMELYSIN;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; CELL SPECIFICITY; COMPUTER; CROSS REACTION; DISEASE COURSE; GENETIC SUSCEPTIBILITY; HEATING; IMMUNIZATION; MALE; MOLECULAR MIMICRY; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; RAT; T LYMPHOCYTE; AMINO ACID SEQUENCE; ANIMAL; ARTHRITIS; CARTILAGE; FLOW CYTOMETRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOLECULAR GENETICS; WISTAR RAT;

AMINO ACID SEQUENCE; ANIMAL; ARTHRITIS, EXPERIMENTAL; AUTOANTIGENS; BACTERIAL PROTEINS; CARTILAGE; CHAPERONINS; CROSS REACTIONS; EPITOPES, T-LYMPHOCYTE; FLOW CYTOMETRY; LYMPHOCYTE ACTIVATION; MALE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; STROMELYSIN 1; ANIMALS; MATRIX METALLOPROTEINASE 3;

EID: 0035990951     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.1080/08916930290024188     Document Type: Article

References (39)

1. Molecular mimicry and immune-mediated diseases
2. Molecular mimicry in T cell mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
3. Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis
4. Identification of high potency microbial and self ligands for a human autoreactive class II restricted T cell clone
5. Autoimmunity in heart disease: Mechanisms and genetic susceptibility
6. Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection
7. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes
8. Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase
9. Peptide recognition, T-cell receptor usage and HLA restriction elements of human heat-shock protein (hsp)-60 and mycobacterial 65-kDa hsp-reactive T-cell clones from rheumatoid synovial fluid
10. Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis
11. Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans
12. Development of arthritis, periarthritis and periostitis in rats given adjuvant
13. Arthritis induced in rats by cloned T lymphocytes responsive to Mycobacteria but not to collagen type II
14. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis
15. Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides
16. Heat shock protein T-cell epitopes as immunogenic carriers in subunit vaccines
17. The rapid isolation of clonable antigen-specific T lymphocytes lines capable of mediating autoimmune encephalomyelitis
18. Determination of lymphocyte division by flow cytometry
19. DDA as an immunological adjuvant
20. Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class II molecules
21. Do epitopes derived from autoantigens display low affinity for MHC class I?
22. Lowering the tone: Mechanisms of immunodominance among epitopes with low affinity for MHC
23. Definition of an extended MHC class II-peptide binding motif for the autoimmune disease-associated Lewis rat RT1.BL molecule
24. A peptide variant of an arthritis-related T cell epitope induces T cells that recognize this epitope as a synthetic peptide but not in its naturally processed form
25. Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: More than blocking alone
26. Self-reactive T cells and degeneracy of T cell recognition: Evolving concepts-from sequence homology to shape mimicry and TCR flexibility
27. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity
28. Sequence homology between yeast histone H3 and uveitopathogenic site of S-antigen: Lymphocyte cross-reaction and adoptive transfer of the disease
29. A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis
30. Highly cross-reactive T cell responses to myelin basic protein epitopes reveal a nonpredictable form of TCR degeneracy
31. Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis
32. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin
33. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues
34. Competence of thoracic duct cells in the transfer of adjuvant disease and delayed hypersensitivity. Evidence that mycobacterial components are required for the successful transfer of the disease
35. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis
36. Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides
37. Induction of experimental autoimmune arthritis by a public epitope of the T cell receptor variable alpha domain of an arthritogenic T cell clone
38. Arthritis in Lewis rats induced by the non-immunogenic adjuvant CP20961: An immunohistochemical analysis of the developing disease
39. Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement