Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease

Cell Biology International

Volumn 26, Issue 6, 2002, Pages 529-539

  Shoeman, Robert L ^a   Hartig, Roland ^a   Hauses, Claudia ^a   Traub, Peter ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Focal adhesion plaque; Focal adhesion plaque kinase; HIV 1 protease; Vimentin; Vinculin

Indexed keywords

ALPHA3 INTEGRIN; BETA4 INTEGRIN; FIBRONECTIN; FILAMIN; FOCAL ADHESION PLAQUE KINASE; PROTEIN; PROTEIN ANTIBODY; PROTEIN FIMBRIN; PROTEINASE; SPECTRIN; TALIN; UNCLASSIFIED DRUG; VINCULIN; ACTIN BINDING PROTEIN; FIMBRIN; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 1; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE; PTK2 PROTEIN, HUMAN; PTK2 PROTEIN, MOUSE; VIMENTIN;

ANIMAL CELL; ARTICLE; CELL PERMEABILIZATION; CONTROLLED STUDY; FIBROBLAST; FOCAL ADHESION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOBLOTTING; IMMUNOREACTIVITY; MICROINJECTION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; ANIMAL; CELL ADHESION; CELL CULTURE; CELL MEMBRANE; DRUG EFFECT; EXTRACELLULAR MATRIX; FETUS; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; MICROFILAMENT; MUTATION; PATHOPHYSIOLOGY; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMALS; CELL ADHESION; CELL MEMBRANE; CELLS, CULTURED; EXTRACELLULAR MATRIX; FETUS; FIBROBLASTS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; HIV INFECTIONS; HIV PROTEASE; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICROFILAMENT PROTEINS; MICROFILAMENTS; MUTATION; PROTEIN-TYROSINE KINASES; TALIN; VIMENTIN; VINCULIN;

EID: 0035989091     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1006/cbir.2002.0895     Document Type: Article

References (69)

1. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
2. Cell-matrix contact structures
3. Relationship between immune complex-dissociated p24 antigen and human-immunodeficiency-virus type-1 RNA titers in plasma-reply
4. Talin: A cytoskeletal component concentrated in adhesion plaques and other sites of actin-membrane interaction
5. Adhesion plaques: Sites of transmembrane interaction between the extracellular matrix and the actin cytoskeleton
6. Cleavage of focal adhesion kinase by different proteases during Src-regulated transformation and apoptosis-distinct roles for calpain and caspases
7. Molecular characterization of human tensin
8. + T cells
9. Impaired fitness of human immunodeficiency virus type I variants with high-level resistance to protease inhibitors
10. Altered distributions of the cytoskeletal proteins vinculin and alpha-actinin in cultured fibroblasts transformed by Rous sarcoma virus
11. Infectious virus with reduced cytopathogenicity resulting from persistent infection of normal lung fibroblasts by HIV type 1 strains
12. Locomotion of tumor cells: A molecular comparison to migrating pre- and post-mitotic leukocytes
13. Infection of primary human placental fibroblasts with HIV-1, HIV-2, and SIV
14. Specific adhesion molecules bind anchoring filaments and endothelial cells in human skin initial lymphatics
15. Integrin signaling
16. TPA induces apoptosis in MPC-11 mouse plasmacytoma cells grown in serum-free medium
17. Hierarchical cleavage of focal adhesion kinase by caspases alters signal transduction during apoptosis of intestinal epithelial cells
18. Binding of fluorescence- and gold-labeled oligodeoxyribonucleotides to cytoplasmic intermediate filaments in epithelial and fibroblast cells
19. Active nuclear import of single-stranded oligonucleotides and their complexes with non-karyophilic macromolecules
20. DNA-mediated transport of the intermediate filament protein vimentin into the nucleus of cultured cells
21. Human immunodeficiency virus type 1 protease microinjected into cultured human skin fibroblasts cleaves vimentin and affects cytoskeletal and nuclear architecture
22. Degradation of cytoskeletal proteins by the human immunodeficiency virus type 1 protease
23. The molecular architecture of focal adhesions
24. Adhesion-linked kinases in cancer; emphasis on Src, focal adhesion kinase and PI 3-kinase
25. F-actin binding site masked by the intramolecular association of vinculin head and tail domains
26. Actin activates a cryptic dimerization potential of the vinculin tail domain
27. Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartments
28. Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions
29. Viral proteinases
30. Differences in turnover rates of vinculin and talin caused by viral transformation and cell density
31. Caspase-mediated cleavage of focal adhesion kinase PP125 (FAK) and disassembly of focal adhesions in human endothelial cell apoptosis
32. Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates
33. Integrin cytoplasmic domain-binding proteins
34. Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase
35. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes
36. HIV-1 DNA in fibroblast cultures infected with urine from HIV-seropositive cytomegalovirus (CMV) excretors
37. Infection of human fibroblasts and osteoblast-like cells with HIV-1
38. The integrin-triggered rescue of T lymphocyte apoptosis is blocked in HIV-l-infected individuals
39. Fibronectin is a non-viral substrate for the HIV proteinase
40. Focal adhesion kinase: A regulator of focal adhesion dynamics and cell movement
41. HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
42. 2+-activated proteinase, thrombin and lysine-specific endoproteinase Lys-C
43. Focal adhesions: Structure and dynamics
44. HIV-1 infection of lung alveolar fibroblasts and macrophages in humans
45. Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cell is a rapid response to angiotensin II
46. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
47. Bidirectional signaling between the cytoskeleton and integrins
48. Characterization of the nucleic acid binding region of the intermediate filament protein vimentin by fluorescence polarization
49. Potential role of the viral protease in human immunodeficiency virus type 1 associated pathogenesis
50. Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein
51. Amino-terminal polypeptides of vimentin are responsible for the changes in nuclear architecture associated with human immunodeficiency virus type 1 protease activity in tissue culture cells
52. Non-viral cellular substrates for human immunodeficiency virus type 1 protease
53. Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease: Actin, desmin, myosin, and tropomyosin
54. Calpains and the cytoskeleton
55. Depletion of focal adhesion kinase by antisense depresses contractile activation of smooth muscle
56. Role of the intermediate filament protein vimentin in delaying senescence and in the spontaneous immortalization of mouse embryo fibroblasts
57. A simple, continuous fluorometric assay for HIV protease
58. Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates
59. Paxillin: A new vinculin-binding protein present in focal adhesions
60. Retroviruses
61. Motility and adhesive properties of high- and low-metastatic murine neoplastic cells
62. Identification, purification, and cell culture assays of retroviral proteases
63. Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases
64. Cleavage of focal adhesion kinase by caspases during apoptosis
65. Cystic diseases of the kidney: Role of adhesion molecules in normal and abnormal tubulogenesis
66. Vinculin knockout results in heart and brain defects during embryonic development
67. Molecular interactions in cell adhesion complexes
68. Molecular diversity of cell-matrix adhesions
69. Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts