Role of neurotrophins in inflammation of the gut

Current Opinion in Investigational Drugs

Volumn 3, Issue 4, 2002, Pages 565-568

  Reinshagen, Max ^a   Von Boyen, Georg ^a   Adler, Guido ^a   Steinkamp, Martin ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Apoptosis; Colitis; Neuropeptide; Neurotrophin; Trk receptor

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCITONIN GENE RELATED PEPTIDE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HYBRID PROTEIN; NERVE GROWTH FACTOR; NEUROPEPTIDE; NEUROTROPHIC FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN RECEPTOR; NEUTRALIZING ANTIBODY; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR; RECOMBINANT NEUROTROPHIN 3; UNCLASSIFIED DRUG;

ACUTE DISEASE; APOPTOSIS; B LYMPHOCYTE; BASOPHIL; CELL DIFFERENTIATION; CELL GROWTH; CELL PROTECTION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CHRONIC DISEASE; COLITIS; COMBINED IMMUNODEFICIENCY; CONSTIPATION; DIARRHEA; ENTERITIS; EPITHELIUM CELL; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; GENE THERAPY; GLIA CELL; HOMEOSTASIS; HUMAN; IMMUNOREGULATION; MACROPHAGE; MAST CELL; MONOCYTE; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; T LYMPHOCYTE; ANIMAL; ARTICLE; ENTEROPATHY; INFLAMMATION; INTESTINE; INTESTINE MUCOSA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; STOMACH MUCOSA;

ANIMAL; EPITHELIAL CELLS; GASTRIC MUCOSA; GASTROINTESTINAL MOTILITY; HOMEOSTASIS; HUMAN; INFLAMMATION; INTESTINAL DISEASES; INTESTINAL MUCOSA; INTESTINES; NERVE GROWTH FACTORS; ANIMALS; HUMANS;

EID: 0035988842     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (37)

1. An enzyme-linked immunoassay for nerve growth factor (NGF): A tool for studying regulatory mechanisms involved in NGF production in brain and in peripheral tissues
2. Localization of neurotrophins and their high-affinity receptors during human enteric nervous system development
3. Nerve growth factor and Trk high affinity receptor (TrkA) gene expression in inflammatory bowel disease
4. Expression of nerve growth factor prohormones in experimental colitis and inflammatory bowel disease
5. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived neurotrophic functions
6. Structural and functional properties of the TRK family of neurotrophin receptors
7. Differential expression of neurotrophins and their tyrosine kinase receptors in the inflamed colon of IL-2 k.o. and CD4+ repopulated SCID-mice suggest neuro-immune interactions
8. Neurotrophin production in inflamed rat intestine
9. Commercial recominant human beta-nerve growth factor and adult rat dorsal root ganglia contain an identical molecular species of NGF prohormone
10. Nerve growth factor regulates expression of neuropeptides genes in adult sensory neurons
11. Neuronal injury increases retrograde axonal transport of the neurotrophins to spinal sensory neurons and motor neurons via multiple receptor mechanisms
12. Protective function of extrinsic sensory neurons in acute rabbit experimental colitis
13. Action of sensory neurons in an experimental rat colitis model of injury and repair
14. Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonic injury
15. Protective role of neurotrophins in experimental inflammation of the rat gut
16. Mice lacking Nerve Growth Factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons
17. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
18. MHC-II-independent CD4+ T cells induce colitis in immunodeficient RAG-/- hosts
19. Nerve growth factor synthesis by intestinal epithelial cells
20. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice
21. Inflammatory signals induce neurotrophin expression in human microglial cells
22. Neurotrophins: The biological paradox of survival factors eliciting apoptosis
23. p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells
24. Nerve growth factor: From neurotrophin to neurokine
25. Neurotrophins: Signals between the nervous and the immune systems
26. Nerve growth factor: A survey of activity on immune and hematopoietic cells
27. Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones
28. Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors
29. Nerve growth factor signal transduction in human B lymphocytes is mediated by gp140trk
30. Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors
31. Mast cells synthesize, store, and release nerve growth factor
32. Cutting edge: Clonally restricted production of the neurotrophins brain-derived neurotropic factor and neurotrophin-3 mRNA by human immune cells and the Th1/Th2-polarized expression of their receptors
33. Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV
34. Recombinant human neurotrophic factors accelerate colonic transit and relieve constipation in humans
35. Blockade of endogenous neurotrophic factors prevents the androgenic rescue of rat spinal motoneurons
36. The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion
37. Neurotrophic molecules: Strategies for designing effective therapeutic molecules in neurodegeneration