Synthesis, biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high affinity for the 5-HT1A receptor and the alpha1-adrenergic receptor

Nuclear Medicine and Biology

Volumn 29, Issue 4, 2002, Pages 375-387

  Heimbold, I ^a   Drews, A ^a   Kretzschmar, M ^a   Varnas K ^b   Hall, H ^b   Halldin, C ^b   Syhre, R ^a   Kraus, W ^c   Pietzsch, H J ^a   Seifert, S ^a   Brust, P ^a   Johannsen, B ^a  

^a INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c BAM FEDERAL INSTITUTE FOR MATERIALS RESEARCH AND TESTING   (Germany)

Author keywords

In vitro and ex vivo autoradiography; Ligand synthesis; Receptor binding assay; Serotonin 5 HT1A receptor; Tc 99m receptor ligand; WAY100635 analogue

Indexed keywords

123 (3 N METHYLAZAPENTANE 1,5 DITHIOLATO)[6 [1 (2 METHOXYPHENYL)PIPERAZIN 4 YL]HEXYL 1 THIOLATO]OXOTECHNETIUM TC 99M; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALPHA 1 ADRENERGIC RECEPTOR; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PRAZOSIN; RADIOLIGAND; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; (3 N METHYLAZAPENTANE 1,5 DITHIOLATO)(6 (1 (2 METHOXYPHENYL)PIPERAZIN 4 YL)HEXYL 1 THIOLATO)OXOTECHNETIUM(V); (3-N-METHYLAZAPENTANE-1,5-DITHIOLATO)(6-(1-(2-METHOXYPHENYL)PIPERAZIN-4-YL)HEXYL-1-THIOLATO)OXOTECHNETIUM(V); PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR; TECHNETIUM; TECHNETIUM COMPLEX;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING COMPETITION; BRAIN; BRAIN CORTEX; CAUDATE NUCLEUS; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; ANIMAL; CADAVER; CHEMICAL STRUCTURE; EVALUATION; IN VITRO STUDY; METABOLISM; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; SYNTHESIS; TISSUE DISTRIBUTION; WISTAR FURTH RAT;

ANIMAL; AUTORADIOGRAPHY; BRAIN; CADAVER; HUMAN; IN VITRO; MALE; MODELS, MOLECULAR; ORGANOTECHNETIUM COMPOUNDS; PIPERAZINES; PYRIDINES; RADIOPHARMACEUTICALS; RATS; RATS, INBRED WF; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, SEROTONIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TECHNETIUM; TISSUE DISTRIBUTION; ANIMALS; HUMANS; RECEPTORS, SEROTONIN, 5-HT1;

EID: 0035988204     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(01)00313-4     Document Type: Article

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