Targeting systemically administered proteins to bone by bisphosphonate conjugation

Biotechnology Progress

Volumn 18, Issue 3, 2002, Pages 604-611

  Uludag, Hasan ^a   Yang, Jennifer ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; BOVINE SERUM ALBUMIN; LYSOZYME;

ANIMAL; ARTICLE; BONE; CHEMISTRY; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; OVARIECTOMY; RAT; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; BONE AND BONES; DIPHOSPHONATES; FEMALE; INJECTIONS, INTRAVENOUS; MURAMIDASE; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN, BOVINE; TISSUE DISTRIBUTION; ANIMAL; SUPPORT, NON-U.S. GOV'T;

INTRAVENOUS INJECTIONS;

AMINO ACIDS; BIOLOGICAL ORGANS; BONE;

PROTEINS;

BOVINAE;

EID: 0035988057     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0200447     Document Type: Article

References (30)

1. Bisphosphonates: Mechanisms of action
2. Administration routes and delivery systems of bisphosphonates for the treatment of bone resorption
3. Bone-seeking radiopharmaceuticals
4. Radiolabeled bone-seeking radiopharmaceuticals
5. Anticancer-agent-linked phosphonates with antiosteolytic and antineoplastic properties: A promising perspective in the treatment of bone-related malignancies
6. Osteoporotic drug delivery system (ODDS) based on bisphosphonic prodrug: V biological disposition and targeting characteristics of osteotropic estradiol
7. Effect of 17β-estradiol bisphosphonate conjugates, potential bone-seeking estrogen prodrugs, on 17β-estradiol serum kinetics on bone mass in rats
8. Prostaglandin E2-bisphosphonate conjugates: Potential agents for treatment of osteoporosis
9. Protein growth factors in bone tissue engineering
10. Stimulation of endosteal bone formation by systemic injections of recombinant basic fibroblast growth factor in rats
11. Infusion of platelet-derived growth factor or bFGF induces selective glomerular mesengial cell proliferation and matrix accumulation in rats
12. Bisphosphonate conjugation to proteins as a means to impart bone affinity
13. Bone affinity of a bisphosphonate-conjugated protein in vivo
14. Synthesis of aminobisphosphonates
15. Bone formation: Osteoblast lineage, growth factors, matrix proteins, and the mineralization process
16. The interactions of proteins with hydroxyapatite: Role of protein charge and structure
17. Improved liquid chromatography separation of different proteins by designing functional surfaces of cattle bone-originated apatite
18. The interactions of proteins with hydroxyapatite: Role of acidic and basic groups
19. Cooperative adsorption of proteins onto hydroxyapatite
20. Adsorption of bovine serum albumin and lysozyme on hydrophobic calcium hydroxyapatites
21. Osteoporotic drug delivery system (ODDS) based on bisphosphonic prodrug: V biological disposition and targeting characteristics of osteotropic estradiol
22. Lymphatic transport of proteins after subcutaneous administration
23. Lymphatic transport of proteins after s.c. injection: Implications of animal model selection
24. Effect of molecular weight on the lymphatic absorption of water soluble compounds following subcutaneous administration
25. Perivascular and intravenous administration of basic fibroblast growth factor: Vascular and solid organ deposition
26. 125I-labeled recombinant fibroblast growth factor 2
27. 125I-labeled recombinant fibroblast growth factor 2
28. Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model
29. Development of tricalcium phosphate/amylopectin paste combined with recombinant human transforming growth factor β 1 as a bone defect filler