Evolutionary and functional analyses of variants of the toxin-coregulated pilus protein TcpA from toxigenic Vibrio cholerae non-O1/nonO139 serogroup isolates

Microbiology

Volumn 148, Issue 6, 2002, Pages 1655-1666

  Boyd, E Fidelma ^a   Waldor, Matthew K ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

CTXphi receptor; Intestinal colonization; Pathogenesis

Indexed keywords

BACTERIAL PROTEIN; BACTERIOPHAGE RECEPTOR; CHOLERA TOXIN; PILIN; POLYMER; PROTEIN SUBUNIT; FIMBRIA PROTEIN; TCPA PROTEIN, VIBRIO CHOLERAE;

ADAPTATION; ALLELE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM PILUS; CARBOXY TERMINAL SEQUENCE; CHROMOSOMAL LOCALIZATION; CLONE; CONTROLLED STUDY; EVOLUTION; GENETIC VARIABILITY; IMMUNE RESPONSE; IN VITRO STUDY; INFECTION SENSITIVITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN POLYMORPHISM; SEROTYPE; VIBRIO CHOLERAE; ANIMAL; BACTERIAL GENE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; FIMBRIA; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETICS; INTESTINE; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PHYLOGENY; PROTEIN CONFORMATION; SUCKLING; VIRULENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); NEGIBACTERIA; TOR; VIBRIO; VIBRIO CHOLERAE;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, SUCKLING; CHOLERA TOXIN; EVOLUTION, MOLECULAR; FIMBRIAE PROTEINS; FIMBRIAE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; INTESTINES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYLOGENY; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; VARIATION (GENETICS); VIBRIO CHOLERAE; VIRULENCE;

EID: 0035987249     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-148-6-1655     Document Type: Article

References (63)

1. Large outbreak of clinical cholera due to Vibrio cholerae non-O1 in Bangladesh
2. Genetic diversity and population structure of Vibrio cholerae
3. Genesis of the novel epidemic Vibrio cholerae O139 strain: Evidence for horizontal transfer of genes involved in polysaccharide synthesis
4. DNA fingerprinting of Vibrio cholerae strains with a novel insertion sequence element: A tool to identify epidemic strains
5. Molecular variation among type IV pilin (bfpA) genes from diverse enteropathogenic Escherichia coli strains
6. Value of phage typing of Vibrio cholerae biotype El Tor in West Africa
7. Diversifying selection governs nucleotide polymorphism in fimbriae pilin genes of Escherichia coli
8. Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica
9. Molecular genetic relationships of the salmonellae
10. Molecular analysis of a putative CTXφ precursor and evidence for independent acquisition of distinct CTXφs by toxigenic Vibrio cholerae
11. Organization of tcp, acf and toxT genes within a ToxT-dependent operon
12. Evolutionary relationships of pathogenic clones of Vibrio cholerae by sequence analysis of four housekeeping genes
13. Virulence genes in environmental strains of Vibrio cholerae
14. The Vibrio cholerae O139 Calcutta CTXφ is infectious and encodes a novel repressor
15. CTX prophages in classical biotype Vibrio cholerae: Functional phage genes but dysfunctional phage genomes
16. Differential expression of the ToxR regulon in classical and E1 T or biotypes of Vibrio cholerae is due to biotype-specific control over toxT expression
17. Genetic exchange among natural isolates of bacteria: Recombination within the phoA gene of Escherichia coli
18. Nucleotide sequence of the structural gene, tcpA, for a major pilin subunit of Vibrio cholerae
19. Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae
20. A search for cholera toxin (CT), toxin coregulated pilus (TCP), the regulatory element ToxR and other virulence factors in non-O1/non-O139 Vibrio cholerae
21. Characterization and distribution of the hemagglutinins produced by Vibrio cholerae
22. DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
23. CTXφ infection of Vibrio cholerae requires the tolQRA gene products
24. Toxin, toxin-coregulated pili and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans
25. Using CLUSTAL for multiple sequence alignments
26. A conserved infection pathway for filamentous bacteriophages is suggested by the structure of the membrane penetration domain of the minor coat protein g3p from phage fd
27. Translocation failure in a type-4 pilin operon: Rfb and tcpT mutants in Vibrio cholerae
28. Role of F pili in the penetration of bacteriophage fl
29. The sixth and seventh cholera pandemics are due to independent clones separately derived from environmental, nontoxigenic, non-O1 Vibrio cholerae
30. A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains
31. Comparison of Vibrio cholerae pathogenicity islands in sixth and seventh pandemic strains
32. Biogenesis and regulation of the Vibrio cholerae toxin-coregulated pilus: Analogies to other virulence factor secretory systems
33. CTXphi immunity: Application in the development of cholera vaccines
34. Delineation of pilin domains required for bacterial association into microcolonies and intestinal colonization by Vibrio cholerae
35. A putative integrase gene defines the distal end of a large cluster of ToxR-regulated colonization genes in Vibrio cholerae
36. Relationship between evolutionary rate and cellular location among the Inv/Spa invasion proteins of Salmonella enterica
37. The tcp gene cluster of Vibrio cholerae
38. Cholera toxin genes: Nucleotide sequence, deletion analysis and vaccine development
39. Characterization of VPI pathogenicity island and CTXphi prophage in environmental strains of Vibrio cholerae
40. Characterization of phenotypic, serological, and toxigenic traits of Vibrio cholerae O139 bengal
41. Molecular characterization of a new variant of toxin-coregulated pilus protein (TcpA) in a toxigenic non-O1/non-O139 strain of Vibrio cholerae
42. Evolutionary genetics of the proline permease gene (putP) and the control region of the proline utilization operon in populations of Salmonella and Escherichia coli
43. Size and sequence polymorphism in the isocitrate dehydrogenase kinase/phosphatase gene (aceK) and flanking regions in strains of Salmonella enterica and Escherichia coli
44. Toxin-co-regulated pilus cluster in non-O1, non-toxigenic Vibrio cholerae: Evidence of a third allele of pilin gene
45. Comparison of the promoter proximal regions of the toxin-co-regulated tcp gene cluster in classical and El Tor strains of Vibrio cholerae O1
46. CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor
47. Characterization of a periplasmic thiol: Disulfide interchange protein required for the functional maturation of secreted virulence factors of Vibrio cholerae
48. Evolutionary relationships among pathogenic and nonpathogenic Escherichia coli strains inferred from multilocus enzyme electrophoresis and mdh sequence studies
49. TcpA pilin sequences and colonization requirements for O1 and O139 Vibrio cholerae
50. The C-terminal domain of TolA is the coreceptor for filamentous phage infection of E. coli
51. The neighbor-joining method: A new method for reconstructing phylogenetic trees
52. RASMOL: Biomolecular graphics for all
53. Vibrio cholerae O395 tcpA pilin gene sequence and comparison of predicted protein structural features to those of type 4 pilins
54. Control of the ToxR virulence regulon in Vibrio cholerae by environmental stimuli
55. Localization of protective epitopes within the pilin subunit of the Vibrio cholerae toxin-coregulated pilus
56. fII, a bacterial locus required for filamentous phage infection and its relation to colicin-tolerant tolA and tolB
57. Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escherichia coli
58. Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin
59. Type 4 fimbriae
60. The toxin-coregulated pilus is a colonization factor and protective antigen of Vibrio cholerae El Tor
61. Lysogenic conversion by a filamentous phage encoding cholera toxin
62. The Vibrio cholerae O139 serogroup antigen includes an O-antigen capsule and lipopolysaccharide virulence determinants
63. An enterotoxin produced by noncholera vibrios