Comparison of the pharmacological properties of cloned rat, human, and bovine norepinephrine transporters

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 2, 1999, Pages 761-767

  Paczkowski, Filip A ^a   Bryan Lluka, Lesley J ^a   Pörzgen, Peter ^a,b   Brüss, Michael ^b   Bönisch, Heinz ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 3',4' DIHYDROXY 2 METHYLPROPIOPHENONE; ADRENALIN; AMINO ACID; CARRIER PROTEIN; COCAINE; COMPLEMENTARY DNA; DESIPRAMINE; DOPAMINE; FLUOXETINE; IMIPRAMINE; NISOXETINE; NORADRENALIN; OXAPROTILINE; PARGYLINE; PAROXETINE; SODIUM ION; TRICYCLIC ANTIDEPRESSANT AGENT; TRITIUM; VANOXERINE;

AMINE TRANSPORT; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATTLE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; MOLECULAR CLONING; NONHUMAN; PHARMACOLOGY; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CARRIER PROTEINS; CATTLE; CLONING, MOLECULAR; COS CELLS; HUMANS; KINETICS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SODIUM; SPECIES SPECIFICITY; SYMPORTERS;

EID: 0032780362     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Amara SG and Kuhar MJ (1993) Neurotransmitter transporters: Recent progress. Annu Rev Neurosci 16:73-93.
2. Barker EL, Kimmel HL and Blakely RD (1994) Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Mol Pharmocol 46:799-807.
3. Blakely RD, Berson HE, Fremeau RT, Caron MG, Peek MM, Prince HK and Bradley CC (1991) Cloning and expression of a functional serotonin transporter from rat brain. Nature (Lond) 854:66-70.
4. Bönisch H and Brüss M (1994) The noradrenaline transporter of the neuronal plasma membrane. Ann N Y Acad Sci 733:193-202.
5. Bönisch H, Fuchs G and Graefe K-H (1986) Sodium-dependence of the saturability of carrier-mediated noradrenaline efflux from noradrenergic neurones in the rat vas deferens. Naunyn-Schmeideberg's Arch Pharmacol 332:131-134.
6. 3H-desipranune to the neuronal noradrenaline carrier of rat phaeochromocytoma cells (PC-12 cells). Naunyn-Schmeideberg's Arch Pharmacol 334:403-411.
7. Borowsky B and Hoffman BJ (1995) Neurotransmitter transporters: Molecular biology, function, and regulation. Int Rev Neurobiol 38:139-199.
8. Brüss M, Pörzgen P, Bryan-Lluka LJ and Bönisch H (1997) The rat norepinephrine transporter: Molecular cloning from PC12 cells and functional expression. Mol Brain Res 52:257-262.
9. Bryan-Lluka LJ and O'Donnell SR (1992) Dopamine and adrenaline, but not isoprenaline, are substrates for uptake and metabolism in isolated perfused lungs of rats. Naunyn-Schmeideberg's Arch Pharmacol 346:20-26.
10. 1 in noradrenergic neurones. Naunyn-Schmeideberg's Arch Pharmacol 345:319-326.
11. Buck KJ and Amara SG (1994) Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium. Proc Natl Acad Sci USA 91:12584-12588.
12. Buck KJ and Amara SG (1995) Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants. Mol Pharmacol 48:1030-1037.
13. Bunn SJ, O'Brien KJ, Boyd TL and Powis DA (1992) Pertussis toxin inhibits noradrenaline accumulation by bovine adrenal medullary chromaffin cells. Naunyn-Schmeideberg's Arch Pharmacol 346:649-656.
14. Bzoskie L, Yen J, Tseng Y-T, Blount L, Kashiwai K and Padbury JF (1997) Human placental norepinephrine transporter mRNA: Expression and correlation with fetal condition at birth. Placenta 18:205-210.
15. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
16. - in transport. Naunyn-Schmeideberg's Arch Pharmacol 333:246-252.
17. Fritz JD, Jayanthi LD, Thoreson MA and Blakely RD (1998) Cloning and chromosomal mapping of the murine norepinephrine transporter. J Neurochem 70:2241-2251.
18. Giros B, El Mestikawy S, Godinot N, Zheng K, Han H, Yang-Feng T and Caron MG (1992) Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol Pharmacol 42:383-390.
19. Giros B, Wang Y-M, Suter S, McLeskey SB, Pifl C and Caron MG (1994) Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. J Biol Chem 269: 15985-15988.
20. Grohmann M (1987) The activity of the neuronal and extraneuronal catecholamine-metabolizing enzymes of the perfused rat heart. Naunyn-Schmeideberg's Arch Pharmacol 336:139-147.
21. Gu H, Wall SC and Rudnick G (1994) Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. J Biol Chem 269:7124-7130.
22. Hoffman BJ, Mezey E and Brownstein MJ (1991) Cloning of a serotonin transporter affected by antidepressants. Science (Wash DC) 264:579-580.
23. Kilty JE, Lorang D and Amara SG (1991) Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science (Wash DC) 254:578-579.
24. Kitayama S, Shimada S, Xu H, Markham L, Donovan DM and Uhl GR (1992) Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci USA 89:7782-7785.
25. + transport. Synapse 16:58-62.
26. + uptake and cocaine binding in bovine dopamine transporter. Neurosci Lett 214:199-201.
27. Lingen B, Brüss M and Bönisch H (1994) Cloning and expression of the bovine sodium- and chloride-dependent noradrenaline transporter. FEBS Lett 342:235-238.
28. Lowry O, Rosebrough N, Farr A and Randall R (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
29. 1B receptors. Nature (Lond) 360:161-163.
30. Pacholczyk T, Blakely RD and Amara SG (1991) Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature (Lond) 350: 350-353.
31. Paczkowski F, Bryan-Lluka LJ, Pörzgen P, Brüss M and Bönisch H (1997) Comparison of pharmacological activities of the rat, bovine and human noradrenaline transporters. Proc Aust Soc Clin Exp Pharmacol Toxicol 4:85.
32. Paczkowski NJ, Vuocolo HE and Bryan-Lluka LJ (1996) Conclusive evidence for distinct transporters for 5-hydroxytryptamine and noradrenaline in pulmonary endothelial cells of the rat. Naunyn-Schmeideberg's Arch Pharmacol 353:423-430.
33. Pifl C, Hornykiewicz O, Giros B and Caron MG (1996) Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: Studies comparing the cloned human noradrenaline and human dopamine transporter. J Pharmacol Exp Ther 277:1437-1443.
34. Pörzgen P, Bryan-Lluka LJ, Paczkowski F, Brüss M and Bönisch H (1997) Characterisation of the recently cloned rat noradrenaline transporter: Comparison with bovine and human transporters. Naunyn-Schmeideberg's Arch Pharmacol 356 (Suppl. 1):R21.
35. Pradier L, Habert-Ortoli E, Emile L, Le Guerin J, Loquet I, Bock M-D, Clot J, Mercken L, Fardin V, Garret C and Mayaux J-F (1995) Molecular determinants of the species selectivity of neurokinin type 1 receptor antagonists. Mol Pharmacol 47:314-321.
36. Ramamoorthy S, Prasad PD, Kulanthaivel P, Leibach FH, Blakely RD and Ganapathy V (1993) Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast. Biochemistry 32:1346-1353.
37. 3H-noradrenaline in isolated vasa deferentia and atria of the rat. Naunyn-Schmeideberg's Arch Pharmacol 340:502-508.
38. Shank RP, Gardocki JF, Schneider CR, Vaught JL, Setter PE, Maryanoff BE and McComsey DF (1987) Preclinical evaluation of McN-5707 as a potential antidepressant. J Pharmacol Exp Ther 242:74-84.
39. Shimada S, Kitayama S, Lin C, Patel A, Nanthakumar E, Gregor P, Kuhar M and Uhl G (1991) Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science (Wash DC) 264:576-578.
40. 1-mediated efflux of catecholamines from pulmonary endothelial cells of perfused lungs of rats. Naunyn-Schmeideberg's Arch Pharmacol 353:528-535.