Dendritic cells crossprime allo-specific self-restricted CD4+ T cells after coculture with dead allogeneic cells

Human Immunology

Volumn 63, Issue 7, 2002, Pages 517-523

  Ciubotariu, Rodica ^a   Tsang, Ming L ^b   Steinman, Ralph M ^b   Suciu Foca, Nicole ^a   Münz, Christian ^b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Crosspriming; Dendritic cells; Indirect alloreactivity

Indexed keywords

CYTOKINE; HLA DR ANTIGEN; HLA DR1 ANTIGEN; HLA DR7 ANTIGEN; HLA DRB1 07 ANTIGEN; HLA-DRB1 ANTIGEN;

ALLOIMMUNITY; ARTICLE; COCULTURE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL; CD4+ T LYMPHOCYTE; CELL LINE; CROSS REACTION; IMMUNOLOGY;

CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; COCULTURE; CROSS REACTIONS; DENDRITIC CELLS; HLA-DR ANTIGENS; HUMAN; TH1 CELLS; COCULTURE TECHNIQUES; HUMANS;

EID: 0035985409     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(02)00403-2     Document Type: Article

References (33)

1. New approaches to specific immunomodulation in transplantation
2. Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo
3. Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection
4. Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides
5. Allorecognition of isolated, denatured chains of class I and class II major histocompatibility complex molecules. Evidence for an important role for indirect allorecognition in transplantation
6. T cell recognition of allopeptides in context of syngeneic MHC
7. Contribution of direct and indirect recognition pathways to T cell alloreactivity
8. Suppression of the indirect pathway of T cell reactivity by high doses of allopeptide
9. Indirect recognition of donor HLA-DR peptides in organ allograft rejection
10. Indirect recognition of donor MHC Class II antigens in human transplantation
11. Mechanism of liver allograft rejection: The indirect recognition pathway
12. Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts
13. MHC soluble, immunoregulation, and tolerance: A progress report
14. T cell recognition of self-human histocompatibility leukocyte antigens (HLA)-DR peptides in context of syngeneic HLA-DR molecules
15. Dendritic cells in transplantation - Friend or foe?
16. Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line
17. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
18. + lymphocytes consistently respond to the EBNA 1 latent EBV antigen
19. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under calf serum-free conditions
20. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application
21. 5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
22. Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells
23. Efficient presentation of phagocytosed cellular fragments on the MHC class II products of dendritic cells
24. Consequences of cell death. Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
25. Innate immune responses to transplants: A significant variable with cadaver donors
26. Chemokines, chemokine receptors, and allograft rejection
27. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
28. Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+CD28- T cells
29. - regulatory T cells
30. Induction of MHC-class I restricted human suppressor T cells by peptide priming in vitro
31. Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells
32. T suppressor lymphocytes inhibit NF-κB-mediated transcription of CD86 gene in APC
33. Distinct mRNA microarray profiles of tolerogenic dendritic cells