Depletion of Vβ5.2/5.3 T cells with a humanized antibody in patients with multiple sclerosis

European Journal of Neurology

Volumn 9, Issue 2, 2002, Pages 153-164

  Olsson, T ^a   Edenius, C ^b   Ferm, M ^b   Samuelson, P ^b   Torrang A ^b   Wallstrom E ^a   Khademi, M ^a   Andersson, M ^a   Arfors L ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Autoimmunity; Clinical trials; Demyelinating disease; Monoclonal antibodies; MRI; T cells

Indexed keywords

ATM 027; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; MYELIN BASIC PROTEIN; RECOMBINANT ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTOANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA; MONOCLONAL ANTIBODY; MYELIN PROTEIN; T CELL RECEPTOR PEPTIDE VBETA5.2;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; IMMUNOREACTIVITY; IMMUNOTHERAPY; MALE; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TARGET CELL; ADOLESCENT; AMINO ACID SEQUENCE; CHEMISTRY; CLINICAL TRIAL; CYTOLOGY; GENE EXPRESSION; GENETICS; IMMUNOLOGY; LYMPHOCYTE COUNT; MIDDLE AGED; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE IMAGING;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; AUTOANTIGENS; FEMALE; GENE EXPRESSION; HUMANS; INTERFERON TYPE II; LYMPHOCYTE COUNT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; MYELIN PROTEINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 0035983035     PISSN: 13515101     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-1331.2002.00370.x     Document Type: Article

References (34)

1. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
2. Cytokine profile in interferon-β, treated multiple sclerosis patients: Reduction of interleukin-10 mRNA, expressing cells in peripheral blood
3. Cardiovascular autonomic function in multiple sclerosis
4. Sensitive mRNA detection using unfixed tissue: Combined radioactive and non-radioactive in situ hybridization histochemistry
5. TCR usage in human and experimental demyelinating disease
6. Detection of intracellular expression and secretion of IFN-γ at the single cell level after activation of human T cells with tetanus toxoid in vitro
7. Autoimmunity to collagen II and myelin basic protein. Comparative studies in man and rodents
8. Preferential T cell receptor beta-chain variable gene use in myelin basic protein-reactive T cell clones from patients with multiple sclerosis
9. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
10. Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis
11. Increased TGF-β, IL-4 and IFN-γ in multiple sclerosis
12. Immunological aspects of demyelinating diseases
13. HLA-DR15 is associated with lower age of onset in multiple sclerosis
14. Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis
15. Expansion of a recurrent Vβ 5.3+ T cell population in newly diagnosed and untreated HLA-DR2 multiple sclerosis patients
16. Augmented expression of tumor necrosis factor α and lymphotoxin mRNA in mononuclear cells in multiple sclerosis and optic neuritis
17. Selection for T cell receptor Vβ-Dβ-Jβ gene arrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis
18. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis
19. Autoreactive T lymphocytes in multiple sclerosis determined by antigen induced secretion of interferon-gamma
20. Exacerbations of multiple sclerosis in patients treated with gamma interferon
21. Quantitative MRI in patients with secondary progressive MS treated with monoclonal antibody Campath 1H
22. MRI in the diagnosis of MS: A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
23. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
24. Multiple sclerosis; a coordinated immunological attack against myelin in the central nervous system
25. Despite epitope spreading in the pathogenesis of autoimmune disease, highly restricted approaches to immune therapy may still succeed
26. Major T-cell responses in multiple sclerosis
27. Pharmacokinetics and metabolism of therapeutic and diagnostic antibodies
28. Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: Results of a randomized, double blind, placebo controlled, MR-monitored phase II trial
29. Treatment of multiple sclerosis with T cell receptor peptides: Results of a double-blind pilot trial
30. The functional significance of epitope spreading and its regulation by co-stimulatory molecules
31. T cell activation determined by T cell receptor number and tunable thresholds
32. Increased reactivity to myelin oligodendrocyte glycoprotein peptides and epitope mapping in DR2 (15)+ multiple sclerosis
33. Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes