Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis

Circulation Research

Volumn 89, Issue 5, 2001, Pages 401-407

  McDermott, David H ^a   Halcox, Julian P J ^a   Schenke, William H ^a   Waclawiw, Myron A ^a   Merrell, Maya N ^a   Epstein, Neal ^a   Quyyumi, Arshed A ^a   Murphy, Philip M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Acetylcholine; Epidemiology; Fractalkine; Genetics; Inflammation

Indexed keywords

ACETYLCHOLINE; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; ISOLEUCINE; NITROPRUSSIDE SODIUM; UNCLASSIFIED DRUG; VALINE;

ADULT; ALLELE; ANGIOGRAPHY; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY BLOOD VESSEL; CORONARY VASCULAR RESISTANCE; DISEASE SEVERITY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOTE; HUMAN; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY; RISK FACTOR; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0035980162     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1701.095642     Document Type: Article

References (53)

1. Atherosclerosis: An inflammatory disease
2. Endothelial function in health and disease: New insights into the genesis of cardiovascular disease
3. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction
4. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart
5. Nitric oxide activity in the human coronary circulation: Impact of risk factors for coronary atherosclerosis
6. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease
7. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
8. The genetics of coronary atherosclerosis
9. Novel risk factors for atherosclerosis
10. Genetic susceptibility to death from coronary heart disease in a study of twins
11. Participation of innate and acquired immunity in atherosclerosis
12. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
13. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis
14. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction
15. Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28→Pro), on lipoproteins and the prevalence of coronary artery disease in whites
16. Peroxisome proliferator-activated receptor γ Cl61→T polymorphism and coronary artery disease
17. Insertion-deletion polymorphism of the ACE gene modulates reversibility of endothelial dysfunction with ACE inhibition
18. Chemokines: Chemotactic cytokines that mediate inflammation
19. International union of pharmacology. XXII. Nomenclature for chemokine receptors
20. -/- mice reveals a role for chemokines in the initiation of atherosclerosis
21. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
22. Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice
23. A new class of membrane-bound chemokine with a CX3C motif
24. Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1
25. Genetic polymorphism in the HIV coreceptor CX3CR1 and risk of HIV disease
26. Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease
27. ACC/AHA guidelines for percutaneous coronary intervention: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1993 Guidelines for Percutaneous Transluminal Coronary Angioplasty)
28. Contribution of nitric oxide to reactive hyperemia: Impact of endothelial dysfunction
29. Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function
30. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: Studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk
31. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study
32. Infection and atherosclerosis: Emerging mechanistic paradigms
33. Does Chlamydia pneumoniae cause atherosclerosis?
34. The possible role of human cytomegalovirus (HCMV) in the origin of atherosclerosis
35. Autoantibodies to modified LDLs and other phospholipid-protein complexes as markers of cardiovascular diseases
36. Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: Evidence for an autoimmune component of atherogenesis
37. Chemokines, leukocytes, and atherosclerosis
38. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
39. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
40. Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow
41. Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction: Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation
42. Inflammatory agents regulate in vivo expression of fractalkine in endothelial cells of the rat heart
43. NF-κB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1β, TNF-α, and LPS
44. Fractalkine-mediated endothelial cell injury by NK cells
45. CX3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and -independent mechanisms
46. Nitric oxide activity in the atherosclerotic human coronary circulation
47. Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia. Comparison of acetylcholine and substance P
48. Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice
49. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease
50. Acute systemic inflammation impairs endothelium-dependent dilatation in humans
51. Relation of inflammation to vascular function in patients with coronary heart disease
52. Constrictor and dilator responses to intracoronary acetylcholine in adjacent segments of the same coronary artery in patients with coronary artery disease: Endothelial function revisited