Neurodegeneration in the central nervous system of apoE-deficient mice

Experimental Neurology

Volumn 136, Issue 2, 1995, Pages 107-122

  Masliah, Eliezer ^a   Mallory, Margaret ^a   Ge, Nianfeng ^a   Alford, Michael ^a   Veinbergs, Isaac ^a   Roses, Allen D ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; TUBULIN;

ADOLESCENT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; IMMUNOCYTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; MUTANT; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; ULTRASTRUCTURE;

AGING; ANIMAL; ANTIBODIES; APOLIPOPROTEINS E; BRAIN; CENTRAL NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED STRAINS; MICROSCOPY, CONFOCAL; NERVE DEGENERATION; PRESYNAPTIC TERMINALS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028844138     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1006/exnr.1995.1088     Document Type: Article

References (53)

1. Alford, M. F., E. Masliah, L. A. Hansen, and R. D. Tèrry. 1994. A simple dot-immunobinding assay for the quantification of synaptophysin-like immunoreactivity in human brain. J. Hi stochern. Cytochem. 42:283-287.
2. ALLAIN, C. C., L. S. POON, C. S. G. CHAN, W. RICHMOND, and R C. FU. 1974. Enzymatic determination of total serum cholesterol. Clin. Chem. 20: 470-475.
3. ANDREWS, T. J., D. Lf, J. HALLIWELL, and T. COWEN. 1994. The effect of age on dendrites in the rat superior cervical ganglion. J. Anat, 184: 111-117.
4. BIFULCO, M., C. LAEZZA, S. M. Aloj, and C. GARBI. 1993. Mevalonate controls cytoskeleton organization and cell morphology in thyroid epithelial cells. J. Cell. Physiol. 155: 340-348.
5. BOYLES, J. K., L. M. NOTTERPEK, and L. J. ANDERSON. 1990. Accumulation of apolipoproteins in the regenerating and remy-elinating mammalian peripheral nerve. J. Biol. Chem. 265: 17805-17815.
6. BOYLES, J. K., R. E. PITAS, E. WILSON, R. W. MAHLEY, and J. M. TAYLOR 1985. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J. Clin. Invest. 76:1501-1513.
7. C ACERES, A., J. BUS CIGLIO, A. FERREIRA, and O. STEWARD. 1988. An immunocytochemical and biochemical study of the microtu-bule-associated protein MAP-2 during post-lesion dendritic remodeling in the central nervous system in adult rats. Mol. Brain Res. 3: 233-246.
8. Caceres, A., and C. Dotti. 1985. Immunocytochemical localization of tubulin and the high molecular weight microtubule-associated protein 2 in purkinje cell dendrites deprived of climbing fibers. Neuroscience 16: 133-150.
9. DIEDRICH, J. F., H. MINNIGAN, R. I. CARP, J. N. WHITAKER, R. RACE, W. FREY, and A. T. HAASE. 1991. Neuropathological changes in scrapie and Alzheimer’s disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes. J. Virol. 65: 4759-4768.
10. GOEDERT, M., R. A. CROWTHER, and C. C. GARNER. 1991. Molecular characterization of microtubule-associated proteins tau and MAP2. Trends Neurosci 14:193-199.
11. GUNDERSEN, G. G., I. KIM, and C. J. CHAPIN. 1994. Induction of stable microtubules in 3T3 fibroblasts by TGF-ß and serum. J. Cell Sci. 107: 645-659.
12. Han, S.-H., G. Einstein, K. H. Weisgraber, W. J. Strittmatter, A. M. Saunders, M. Vance-Pericak, A. D. ROSES, and D. E. Schmechel. 1994. Apolipoprotein E is localized to the cytoplasm of human cortical neurons. A light and electron microscopic study. J. Neuropathol. Exp. Neurol. 53: 535-544.
13. HAN, S-H., C. HULETTE, A. M. SAUNDERS, G. EINSTEIN, M. PERICAK-VANCB, W. J. STRITTMATTER, A. D. ROSES, and D. E. SCHMECHEL. 1994. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer’s disease and in age-matched controls. Exp. Neurol. 128: 13-26.
14. HANDELMANN, G. E., J. K. BOYLES, K. H. WEISGRABER, R. W. MAHLEY, and R. E. PITAS. 1992. Effects of apolipoprotein E, ß-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in uitro. J. Lipid Res. 33:1677-1688.
15. IGNATIUS, M. J., E. M. SHOOTER, R. E. PITAS, and R. W. MAHLEY. 1987. Lipoprotein uptake by neuronal growth cones in vitro. Science 236: 959-962.
16. ITO, J., M. MASUDA, and R. TANAKA. 1994. Sialosylcholesterol effects on reconstitution of microfilament and glia filament. J. Neurochem. 62: 235-239.
17. JOACHIM, C. L., H. MORI, and D. J. SELKOE. 1989. Amyloid beta-protein deposition in tissues other than brain in Alzheimer’s disease. Nature 341: 226-230.
18. KREIS, T. E. 1987. MICROTUBULES CONTAINING DETYROSINATED TUBULIN ARE LESS DYNAMIC. EMBO J. 6: 2597-2606.
19. KUZNETSOV, S. A., Y. A. VAISBERG, S. W. ROTHWELL, D. B. MURPHY, and V. I. GELFAND. 1989. Isolation of a 4-kDa fragment from the kinesin heavy chain with enhanced ATPase and microtubule-binding activities. J. Biol. Chem. 264: 589-595.
20. LOWRY, O. H., N. J. ROSENBROUGH, A. L. FARR, and R. J. RANDALL. 1951. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265-272.
21. LUDES, B., A. C. SCHMIT, G. CREMEL, A. M. LAMBERT, P. HUBERT, D. JACQMIN, C. BOLLACK, and C. STAEDEL. 1993. Influence of cholesterol derivatives on cytoskeletal organization of human carcinoma cells. Eur. Urol. 23:490-501.
22. MASLIAH, E., C. L. ACHIM, N. GE, R. DETERESA, R. D. TERRY, and C. A. WILEY. 1992. Spectrum of human immunodeficiency virus-associated neocortical damage. Ann. Neurol. 32: 321-329.
23. MASLIAH, E., M. ELLISMAN, B. CARRAGHER, M. MALLORY, S. YOUNG, L. HANSEN, R. DETERESA, and R. D. TRRY. 1992. Three-dimensional analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer disease. J. Neuro-pathol. Exp. Neurol. 51: 404-414.
24. MASLIAH, E., A. M. FAGAN, R. D. TÜRRY, R. DETERESA, M. MALLORY, and F. H. GAGE, 1991. Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat. Exp. Neurol. 113: 131-142.
25. MASLIAH, E., M. MALLORY, M. ALFORD, L. A. HANSEN, and T. SAITOH. 1993. Immunoreactivity of the nuclear antigen pl05 is associated with plaques and tangles in Alzheimer’s disease. Lab. Invest. 69: 562-569.
26. MASLIAH, E., M. MALLORY, M. ALFORD, and L. MUCKE. 1994. Abnormal synaptic regeneration in hAPP transgenic and APOE-knockout mice. Neurobiol. Aging 15: SII.
27. MASLIAH, E., M. MALLORY, N. GE, G. GODSON, and T. SAITOH. 1993. Phorbol ester-induced neuritic alterations in the rat neocortex. Structural and immunocytochemical studies. Mol. Chem. Neuropathol. 20:125-145.
28. MASLIAH, E., M. MALLORY, L. HANSEN, M. ALFORD, T. ALBRIGHT, R. DETERESA, R. D. TERRY, J. BAUDIER, and T. SAITOH. 1991. Patterns of aberrant sprouting in Alzheimer disease. Neuron 6: 729-739.
29. MCKEE, A. C., K. S. KOSIK, and N. W. KOWALL. 1991. Neuritic pathology and dementia in Alzheimer’s disease. Ann. Neurol.30:156-165.
30. MCNEILL, T. H., L. L. KOEK, S. A. BROWN, and J. A. RAFOLS. 1990. Quantitative analysis of age-related dendritic changes in medium spiny 1 (MSI) striatal neurons of C57BL/6N mice. Neurobiol. Aging 11:573-650.
31. NAMBA, Y., M. TOMONAGA, H. KAWASAKI, E. OTO MO, and K. IKEDA. 1991. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer’s disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541:163-166.
32. NAM BA, Y., H. TSUCHIYA, and K. IKEDA. 1992. Apolipoprotein B immunoreactivity in senile plaque and vascular amyloids and neurofibrillary tangles in the brains of patients with Alzheimer’s disease. Neurosci. LeU. 134: 264-266.
33. Nathan, B. P., S. Bellosta, D. A. Sanan, K. H. Weisgraber, R. W. Mahley, and R. E. Pitas. 1994. Differential effects of apolipo-proteins E3 and E4 on neuronal growth in vitro. Science 264: 850-852.
34. OHANLON, G. M., and M. B. LOWRIE. 1993. Evidence for age-dependent changes in motoneuron dendritic morphology following neonatal nerve-crush in the rat. Neuroscience 95-1005.
35. PIPERNO, G., M. LEDIZET, and X. J. CHANG. 1987. Microtubules containing acetylated alpaa-tubulin in mammalian cells in culture. J. Cell Biol. 104: 289-302.
36. Pitas, R. E., J. K. Boyles, S. H. Lee, D. Foss, and R. W. Mahley. 1987. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein. E-containirig lipoproteins. Biochem. Biophys. Res. Commun. 917:148-161.
37. PITAS, R. E., T. L. INNERARITY, J. N. WEINSTEIN, and R. W. MAHLEY. 1981. Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy. Arteriosclerosis 1:177-185.
38. PLUMP, A. S., J. D. SMITH, T. HAYEK, K. AALTO-SETALA, A. WALSH, J. G. VERSTUYFT, E. M. RUBIN, and J. L. BRESLOW. 1992. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71: 343-353.
39. POIRIER, J., A. BACCICHET, D. DEA, and S. GAUTHIER. 1993. Cholesterol synthesis and lipoprotein reuptake during synaptic remodeling in hippocampus in adult rats. Neuroscience 55: 81-90.
40. POIRIER, J., M. HESS, P. C. May, and C. E. FINCH. 1991. Apolipoprotein E-and GFÄP-RNA in hippocampus during reactive synaptogenesis and terminal proliferation. Molee. Brain Res. 11: 97-106.
41. POPKO, B., J. F. GOODRUM, T. W. BOULDIN, S. H. Zhang, and N. MAEDA. 1993. Nerve regeneration occurs in the absence of apolipoprotein E in mice. J. Neurochem. 60: 1155-1158.
42. REBECK, G. W., J. S. REITER, D. K. STRICKLAND, and B. T. HYMAN. 1993. Apolipoprotein E in sporadic Alzheimer’s disease: allelic variation and receptor interactions. Neuron 11: 575-580.
43. SATO-YOSHITAKE, R., H. YORIFUJI, M. INAGAKI, and N. HIROKAWA. 1992. The phosphorylation of kinesin regulates its binding to synaptic vesicles. J. Biol. Chem. 267: 23930-23936.
44. SAUNDERS, A. M., W. J. STRITTMATTER, D. SCHMECHEL, P. H. GEORGE-HYSLOP, M. A. PERICAK-VANCE, S. H. Joo, B. L. Rosi, J. F. GUSELLA, D. R. CRAPPER-MACLACHLAN, M. J. ALBERTS, C. HULETTE, B. CRAIN, D. GOLDGABER, and A. D. ROSES. 1993. Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer’s disease. Neurology 43:1467-1472.
45. SCHMECHEL, D. E., A. M. SAUNDERS, W. J. STRITTMATTER, B. J. CRAIN, C. M. HULETTE, S. H. Joo, M. A. PERICAL-VANCE, D. GOLDGABER, and A. D. ROSES. 1993. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc. Natl. Acad. Set. USA 90: 9649-9653.
46. STEWARD, O., and S. L. VINSANT. 1983. The process of reinnervation in the dentate gyrus of the adult rat: a quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis. J. Comp. Neurol. 214: 370-386.
47. Strittmatter, W. J., A. M. Saunders, D. Schmechel, M. Pericak-Vance, J. En child, G. S. Salvesen, and A. D. Roses. 1993. Apolipoprotein E: High-avidity binding to ß-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA 90:1977-1981.
48. STRITTMATTER, W. J., K. H. WEISGRABER, M. GOEDERT, A. M. SAUNDERS, D. HUANG, E. H. CORDER, L. M. DONG, R. JAKES, M. J. ALBERTS, and J. R. GILBERT. 1994. Hypothesis: Microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp. Neurol. 125: 163-171.
49. STRITTMATTER, W. J., K. H. WEISGRABER, D. Y. HUANG, L. M. DONG, G. S. SALVESEN, M. PERICAK-VANCE, D. SCHMECHEL, A. M. SAUNDERS, D. GOLDGABER, and A. D. ROSES. 1993. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 90: 8098-8102.
50. TERRY, R. D., L. HANSEN, and E. MASLIAH. 1994. Structural alterations in Alzheimer disease. In Alzheimer disease. (R. D. Terry and R. Katzman, Eds.), pp. 179-196. Raven Press, New York.
51. TOGGAS, S. M., E. MASLIAH, E. M. ROCKENSTEIN, and L. MUCKE. 1994. Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice. Nature 367: 188-193.
52. WALAAS, S. I., R. JAHN, and P. GREENGARD. 1988. Quantitation of nerve terminal populations: synaptic vesicle-associated proteins on markers of synaptic density in the rat neostriatum. Synapse 2: 516-520.
53. WISNIEWSKI, T., A. GOLABEK, E. MATSUBARA, J. GHISO, and B. FRANGIONE. 1993. Apolipoprotein E: binding to soluble Alzheimer’s ß-amyloid. Biochem. Biophys. Res. Commun. 192: 359-365.