New multidrug-resistance-reversing drugs, MS-209 and SDZ PSC 833

Cancer Chemotherapy and Pharmacology, Supplement

Volumn 40, Issue , 1997, Pages

  Naito, Mikihiko ^a   Tsuruo, Takashi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

MDR reversal; MRK 16; MS 209; SDZ PSC 833

Indexed keywords

5 [3 (4 DIPHENYLACETYL 1 PIPERAZINYL) 2 HYDROXYPROPOXY]QUINOLINE; ANTINEOPLASTIC AGENT; CYCLOSPORIN A; DOXORUBICIN; GLYCOPROTEIN P; MONOCLONAL ANTIBODY MRK 16; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VALSPODAR; VINCRISTINE;

ANIMAL CELL; ANIMAL MODEL; CELL LINE; CELL STRAIN K 562; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA L 1210; LEUKEMIA P 388; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CYCLOSPORINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; QUINOLINES; TUMOR CELLS, CULTURED;

EID: 0030788302     PISSN: 09439404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (26)

1. Archinal-Mattheis A, Rzepka RW, Watanabe T, Kokubu N, Itoh Y, Combates NJ, Bair KW, Cohen D (1995) Analysis of the interaction of SDZ PSC 833 ([3′-keto-Bmt1]-Val2]-cyclosporin), a multidrug resistance modulator, with P-glycoprotein. Oncol Res 7:603
2. Baba M, Nakanishi O, Sato W, Saito A, Miyama Y, Yano O, Shimada S, Fukazawa N, Naito M, Tsuruo T (1995) Relationship between multidrug resistant gene expression and multidrug resistant-reversing effect of MS-209 in various tumor cells. Cancer Chemother Pharmacol 36:361
3. Boesch D, Gaveriaux C, Jachez B, Pourtier-Manzanedo A, Bollinger P, Loor F (1991) In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res 51:4226
4. Boesch D, Muller K, Pourtier-Manzanedo A, Loor F (1991) Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a non-immunosuppressive cyclosporin derivative. Exp Cell Res 196:26
5. Dalton WS, Grogan TM, Meltzer PS, Scheper RJ, Durie BGM, Taylor CW, Miller TP, Salmon SE (1989) Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J Clin Oncol 7:415
6. Endicott JA, Ling V (1989) The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58:137
7. Keller RP, Altermatt HJ, Nooter K, Poschman G, Laissue JA, Bollinger P, Hiestand PC (1992) SDZ PSC 833, a non-immunosuppressive cyclosporin: its potency in overcoming P-glycoprotein-mediated multidrug resistance of murine leukemia. Int J Cancer 50:593
8. Keller RP, Altermatt HJ, Donatsch P, Zihlmann H, Laissue JA, Hiestand PC (1992) Pharmacologic interactions between the resistance-modifying cyclosporin SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity. Int J Cancer 51:433
9. Miller TP, Grogan TM, Dalton WS, Spier CM, Scheper RJ, Salmon SE (1991) P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil. J Clin Oncol 9:17
10. Naito M, Tsuge H, Kuroko C, Koyama T, Tomida A, Tatsuta T, Heike Y, Tsuruo T (1993) Enhancement of cellular accumulation of cyclosporin by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. J Natl Cancer Inst 85:311
11. Naito M, Watanabe T, Tsuge H, Koyama T, Oh-hara T, Tsuruo T (1996) Potentiation of the reversal activity of SDZ PSC833 on multidrug resistance by an anti-P-glycoprotein monoclonal antibody, MRK-16. Int J Cancer 67:435
12. Pastan I, Gottesman MM (1987) Multiple-drug resistance in human cancer. N Engl J Med 316:1388
13. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T (1993) Human P-glycoprotein transports cyclosporin A and FK-506. J Biol Chem 268:6077
14. Sato W, Fukazawa N, Nakanishi O, Baba M, Suzuki T, Yano O, Naito M, Tsuruo T (1995) Reversal of multidrug resistance by a novel quinoline derivative, MS-209. Cancer Chemother Pharmacol 35:271
15. Shirai A, Naito M, Tatsuta T, Dong J, Hanaoka K, Mikami K, Ohhara T, Tsuruo T (1994) Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein. Biochim Biophys Acta 1222:400
16. Slater LM, Sweet P, Stupecky M, Gupta S (1986) Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro. J Clin Invest 77:1405
17. Slater LM, Sweet P, Stupecky M, Wetzel MW, Gupta S (1986) Cyclosporin A corrects daunorubicin resistance in Ehrlich ascites carcinoma. Br J Cancer 54:235
18. Sonneveld P, Durie BGM, Lokhorst HM, Marie JP, Solbu G, Sucin S, Zittoun R, Lswenberg B, Nooter K (1992) Modulation of multidrug-resistant multiple myeloma by cyclosporin. Lancet 340:255
19. Tsuruo T (1988) Mechanism of multidrug resistance and implications for therapy. Jpn J Cancer Res 79:285
20. Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y (1981) Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41:1967
21. Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y (1982) Increased accumulation of vincristine and adriamycin in drug-resistant tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Res 42:4730
22. Tsuruo T, Iida-Saito H, Kawabata H, Oh-hara T, Hamada H, Utakoji T (1986) Characteristics of resistance to Adriamycin in human myelogenous leukemia K562 resistant to Adriamycin and in isolated clones. Jpn J Cancer Res 77:682
23. Twentyman PR (1988) Modification of cytotoxic drug resistance by non-immuno-suppressive cyclosporins. Br J Cancer 57:254
24. Watanabe T, Tsuge H, Oh-hara T, Naito M, Tsuruo T (1995) Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo. Acta Oncol 34:235
25. Watanabe T, Naito M, Oh-hara T, Itoh Y, Cohen D, Tsuruo T (1996) Modulation of multidrug resistance by SDZ PSC 833 in leukemic and solid tumor-bearing mice model. Jpn J Cancer Res 87:184
26. Yusa K, Tsuruo T (1989) Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells. Cancer Res 49:5002