Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis

Carcinogenesis

Volumn 17, Issue 2, 1996, Pages 185-190

  O'Brien, M L ^a   Rangwala, S M ^b   Henry, K W ^a   Weinberger, C ^c   Crick, D C ^a   Waechter, C J ^a   Feller, D R ^d   Noonan, D J ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESOL; PEROXISOME PROLIFERATOR; RETINOID X RECEPTOR; STEROID RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA TRANSCRIPTION; LIPID METABOLISM; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; NONHUMAN; OXIDATIVE STRESS; PEROXISOME; PRIORITY JOURNAL; RAT; TUMOR PROMOTION;

ACYL-COA OXIDASE; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; FARNESOL; FATTY ACIDS, UNSATURATED; LIVER NEOPLASMS; LOVASTATIN; MICROBODIES; OXIDOREDUCTASES; POLYISOPRENYL PHOSPHATES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS;

EID: 0029940553     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.2.185     Document Type: Article

References (51)

1. Moody,D.E., Reddy,J.K., Lake,B.G., Popp,J.A. and Reese,D.H. (1991) Peroxisome proliferation and nongenotoxic carcinogenesis: commentary on a Symposium. Fund. Appl. Toxicol., 16, 233-248.
2. Reisenbichler,H. and Eckl,P.M (1993) Genotoxic effects of selected peroxisome proliferators. Mutai. Res., 286, 135-144.
3. Hwang,J.J., Hsia,M.T. and Jirtle,R.L. (1993) Induction of sister chromatid exchange and micronuclei in primary cultures of rat and human hepatocytes by the peroxisome proliferator, Wy-14,643. Mutar. Res., 286, 123-133.
4. Elcombe,C.R. (1985) Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: a biochemical human hazard assessment. Arch. Toxicol., 8 (Suppl.), 6-17.
5. Rao,M.S. and Reddy,J.K. (1987) Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis, 8, 631-636.
6. Reddy,J.K. and Azarnoff,D.L. (1980) Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature, 283, 397-398.
7. Lazarow,P.B. and De Duve,C. (1976) A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug. Proc. Natl Acad. Sci. USA, 73, 2043-2046.
8. Issemann,I. and Green,S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347, 645-650.
9. Evans,R.M. (1988) The steroid and thyroid hormone receptor superfamily. Science, 240, 889-895.
10. Beato,M. (1989) Gene regulation by steroid hormones. Cell, 56, 335-344.
11. Chen,F., Law,S.W. and O'Malley,B.W. (1993) Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem. Biophys. Res. Commun., 196, 671-677.
12. Zhu,Y., Alvares,K., Huang,Q., Rao,M.S. and Reddy,J.K. (1993) Cloning of a new member of the peroxisome proliferator-activated gene family from mouse liver. J. Biol. Chem., 268, 26817-26820.
13. Dreyer,C., Krey,G., Keller,H., Givel,F., Helftenbein,G. and Wahli,W. (1992) Control of the peroxisomal b-oxidation pathway by a novel family of nuclear hormone receptors. Cell, 68, 879-887.
14. Göttlicher,M., Widmark,E., Li,Q. and Gustafsson,J.-Å. (1992) Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl Acad. Sci. USA, 89, 4653-4657.
15. Sher,T., Yi,H.F., McBride,O.W. and Gonzalez,F.J. (1993) cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry, 32, 5598-5604.
16. Greene,M.E., Blumberg,B., McBride,O.W., Yi,H.F., Kronquist,K., Kwan,K., Hsieh,L., Greene,G. and Nimer,S.D. (1995) Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr., 4, 281-299.
17. Tugwood,J.D., Isseman,I., Anderson,R.G., Bundell,K.R., Mcpheat,W.L. and Green,S. (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′-flanking sequence of the rat acyl CoA oxidase gene. EMBO J., 11, 433-439.
18. Zhang,B., Marcus,S.L., Sajjadi,F.G., Alvares,K., Reddy,J.K., Subramani,S., Rachubinski,R.A. and Capone,J.P. (1992) Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enol-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc. Natl Acad. Sci. USA, 89, 7541-7545.
19. Tontonoz,P., Hu,E., Graves,R.A., Budavari,A.I. and Spiegelman,B.M. (1994) mPPARg2: tissue-specific regulator of an adipocyte enhancer. Genes Dev., 8, 1224-1234.
20. Rodriguez,J.C, Gil-Gomez,G., Hegardt,F.G. and Haro,D. (1994) Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J. Biol. Chem., 269, 18767-18772.
21. Kliewer,S.A., Umesono,K., Noonan,D.J., Heyman,R.A. and Evans,R.M. (1992) Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature, 358, 771-774.
22. Henry,K., O'Brien,M.L., Clevenger,W., Jow,L. and Noonan,D.J. (1995) Peroxisome proliferator-activated receptor response specificities as defined in yeast and mammalian cell transcription assays. Toxicol. Appl. Pharmacol., 132, 317-324.
23. O'Brien,M., Rangwala,S., Feller,D.R. and Noonan,D.J. (1995) A mechanism for calcium mediated peroxisome proliferation. Biochem. Pharmacol., (submitted).
24. Espandiari,P., Thomas,V.A., Glauert,H.P., O'Brien,M., Noonan,D. and Robertson,L.W. (1995) The herbicide dicamba (2-methoxy-3,6-dichlorobenzoic acid) is a peroxisome proliferator in rats. Fund. Appl. Toxicol., 26, 85-90.
25. Green,S. and Wahli,W. (1994) Peroxisome proliferator-activated receptors: finding the orphan a home. Mol. Cell. Endocrinol., 100, 149-153.
26. Cannon,J.R. and Eacho,P.I. (1991) Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding rpotein from rat liver. Biochem. J., 280, 387-391.
27. Dreyer,C., Keller,H., Mahfoudi,A., Laudet,V., Krey,G. and Wahli,W. (1993) Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol. Cell, 77, 67-76.
28. Issemann,I., Prince,R., Tugwood,J. and Green,S. (1992) A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation? Biochem. Soc. Trans., 20, 824-827.
29. Giguere,V., Hollenberg,S.M., Rosenfeld,M.G. and Evans,R.M. (1986) Functional domains of the human glucocorticoid receptor. Cell. 46, 645-652.
30. Berger,T.S., Parandoosh,Z., Perrv,B.W. and Stein R.B.J.S.B.M.B., 1992. (1992) Interaction of glucocorticoid analogs with the glucocorticoid receptor. J. Steroid Biochem. Mol. Biol., 4, 733-738.
31. Bradford,M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
32. Walusimbi-Kisitu,M. and Harrison,E.H. (1983) Fluorometric assay for rat liver peroxisomal fatty acyl-coenzyme A oxidase activity. J. Lipid Res., 24, 1077-1084.
33. Forman,B.M., Goode,E., Chen,J., Oro,A.E. et al. (1995) Identification of a nuclear receptor that is activated by farnesol metabolites. Cell, 81, 687-693.
34. McDonnell,D.P., Pike,J.W., Drutz,D.J., Butt,T.R. and O'Malley,B.W. (1989) Reconstitution of the vitamin D3 responsive osteocalcin transcription unit in yeast. Mol. Cell. Biol., 39, 3517-3523.
35. Pham,T.A., Hwung,Y., McDonnell,D.P. and O'Malley,B.W. (1991) Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo. J. Biol. Chem., 266, 18179-18187.
36. Allegretto,E.A., McClurg,M.R., Lazarchik,S.B. et al. (1993) Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. J. Biol. Chem., 268, 26625-26633.
37. Ito,H., Fukuda,Y., Murata,K. and Kimura,A. (1983) Transformation of intact yeast cells with alkali cations. J. Bacterial., 153, 163-186.
38. Krisans,S.K. (1992) The role of peroxisomes in cholesterol metabolism. Am. J. Respir. Cell Mol. Biol., 7, 358-364.
39. Bergstrom,J.D., Kurtz,M.M., Rew,D.J. et al. (1993) Zaragozic acids: A family of fungal metabolites that are picomolar competitive inhibitors of squalene synthetase. Proc. Natl Acad. Sci. USA, 90, 80-84.
40. Crick,D.C., Waechter,C.J. and Andres,D.A. (1994) Utilization of geranylgeraniol for protein isoprenylation in C6 glial cells. Biochem. Biophys. Res. Commun., 205, 955-961.
41. Crick,D.C., Andres,D.A. and Waechter,C.J. (1995) Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. Biochem. Biophys. Res. Commun., 211, 590-599.
42. Bradfute,D.L. and Simoni,R.D. (1994) Non-sterol compounds that regulate cholesterogenesis. Analogues of famesyl pyrophosphate reduce 3-hydroxy-3-methylglutaryl-coenzyme A reductase levels. J. Biol. Chem., 269, 6645-6650.
43. Correll,C.C., Ng,L. and Edwards,P.A. (1994) Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem., 269, 17390-17393.
44. Bansal,V.S. and Vaidya,S. (1994) Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes. Arch. Biochem. Biophys., 315, 393-399.
45. Bostedor,R.G., Karkas,J.D., Gemershausen,J.I., Kurtz,M.M., Arison,B.H., Bansal,V.S., Vaidva,S. and Bergstrom,J.D. (1995) Famesol-derived dicarboxylic acids in the urine of animals treated with a squalene synthase inhibitor or fed farnesol. FASEB J., 9, A1317.
46. Mukherjee,R., Jow,L., Noonan,D.J. and McDonnell,D.P. (1994) Human and rat peroxisome proliferator-activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J. Steroid Biochem. Mol. Biol., 51, 157-166.
47. Bentley,P., Calder I., Elcombe,C., Grasso,R., Stringer,D. and Wiegand,H.J. (1993) Hepatic peroxisome proliferation in rodents and its significance for humans. Food Chem. Toxicol., 31, 857-907.
48. Hijikata,M., Ishii,N., Kagamiyama,H., Osumi,T. and Hashimoto,T. (1987) Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase. J. Biol. Chem., 262, 8151-8158.
49. Hijikata,M., Wen,J.K., Osumi,T. and Hashimoto,T. (1990) Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes. J. Biol. Chem., 265, 4600-4606.
50. Bodnar,A.G. and Rachubinski,R.A. (1990) Cloning and sequence determination of cDNA encoding a second rat liver peroxisomal 3-ketoacyl-CoA thiolase. Gene, 91, 193-199.
51. Bout,A., Franse,M.M., Collins,J., Blonden,L., Tager,J.M. and Benne,R. (1991) Characterization of the gene encoding human peroxisomal 3-oxoacyl-CoA thiolase (ACAA). No large DNA rearrangement in a thiolase-deficient patient. Biochim. Biophys. Acta, 1090, 43-51.