Evidence That Ligand and Metal Ion Binding to Integrin α 4β1 Are Regulated through a Coupled Equilibrium

Journal of Biological Chemistry

Volumn 276, Issue 39, 2001, Pages 36520-36529

  Ling Chen, Ling ^b   Whitty, Adrian ^b   Scott, Daniel ^b   Lee, Wen Cherng ^b   Cornebise, Mark ^b   Adams, Steven P ^b   Petter, Russell C ^b   Lobb, Roy R ^b   Pepinsky, R Blake ^a  

^a BIOGEN   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CELLS; POSITIVE IONS;

LIGANDS;

BIOCHEMISTRY;

2 [(1 BENZENESULFONYLPYRROLIDINE 2 CARBONYL)AMINO] 4 [4 METHYL 2 [METHYL [2 [4 (3 O TOLYLUREIDO)PHENYL]ACETYL]AMINO]PENTANOYLAMINO]BUTYRIC ACID; 4 [(N' 2 METHYLPHENYL)UREIDO]PHENYLACETYLLEUCYLGLUTAMYLVALYLPROLINE; ALPHA4 INTEGRIN; BETA1 INTEGRIN; BIO 1211; BIO 7662; BUTYRIC ACID DERIVATIVE; CALCIUM; EDETIC ACID; INHIBITOR PROTEIN; MAGNESIUM ION; MANGANESE; METAL ION; UNCLASSIFIED DRUG; 2 ((1 BENZENESULFONYLPYRROLIDINE 2 CARBONYL)AMINO) 4 (4 METHYL 2 (METHYL (2 (4 (3 O TOLYLUREIDO)PHENYL)ACETYL)AMINO)PENTANOYLAMINO)BUTYRIC ACID; 2-((1-BENZENESULFONYLPYRROLIDINE-2-CARBONYL)AMINO)-4-(4-METHYL-2-(METHYL-(2-(4-(3-O-TOLYLUREIDO)PHENYL)ACETYL)AMINO)PENTANOYLAMINO)BUTYRIC ACID; BENZOIC ACID DERIVATIVE; CARBANILAMIDE DERIVATIVE; CATION; DIPEPTIDE; HOMING RECEPTOR; INTEGRIN; ION; LIGAND; MAGNESIUM; VERY LATE ACTIVATION ANTIGEN 4;

ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; DRUG STRUCTURE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; KINETICS; METABOLISM; PROTEIN BINDING; TIME;

BENZOIC ACIDS; CALCIUM; CATIONS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; EDETIC ACID; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRINS; IONS; JURKAT CELLS; KINETICS; LIGANDS; MAGNESIUM; MANGANESE; MODELS, CHEMICAL; PHENYLUREA COMPOUNDS; PROTEIN BINDING; RECEPTORS, LYMPHOCYTE HOMING; TIME FACTORS;

EID: 0035965303     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106216200     Document Type: Article

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