Copolymer 1 inhibits manifestations of graft rejection

Transplantation

Volumn 72, Issue 4, 2001, Pages 598-605

  Aharoni, R ^a   Teitelbaum, D ^a   Arnon, R ^a   Sela, M ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLATIRAMER; INTERLEUKIN 2; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; FEMALE; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; IMMUNOREACTIVITY; LYMPH NODE CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MINOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN GRAFT; SPLEEN CELL; SURVIVAL TIME; SYMPTOM; TH1 CELL; THYROID SURGERY;

EID: 0035959296     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200108270-00007     Document Type: Article

References (21)

1. The mechanism of action of FK-506 and cyclosporin A
2. Combination of immunosuppressive drugs for organ transplantation
3. Immunopharmacology of rapamycin
4. Outcome statistics of renal transplants with an emphasis on long-term survival
5. Immunobiology of transplantation
6. Antigen processing and presentation in transplantation
7. Cytokines and the Th1/Th2 paradigm in transplantation
8. Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules
9. Development of copolymer 1 (Copaxone) as a specific drug against multiple sclerosis
10. Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability
11. Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells: Specificity and promiscuity
12. Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis
13. A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative response to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo
14. Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease
15. Comparative immunopharmacologic effects of FK506 and CyA in in vivo models of organ transplantation
16. Use of rapamycin for the suppression of alloimmune reactions in vivo: Schedule dependence, tolerance induction, synergy with CyA and FK506 and effect on host-versus-graft and graft-versus-host reactions
17. Differential immunogenic expression of an H-2-linked histocompatibility antigen on different tissues
18. Antigen-induced tolerance to organ allografts
19. Selective immunosuppression of class II-restricted T cells by MHC class II-binding peptides
20. Mechanisms of transplantation tolerance
21. Functional diversity of helper T lymphocytes