A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 10, 1996, Pages 5061-5066

  Schlegel, Paul G ^a   Aharoni, Rina ^b   Chen, Yanfei ^a   Chen, Jun ^a   Teitelbaum, Dvora ^b   Arnon, Ruth ^b   Sela, Michael ^b   Chao, Nelson J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

MURINAE;

ALANINE; AMINO ACID COPOLYMER; BIOLOGICAL RESPONSE MODIFIER; CD4 ANTIGEN; CD8 ANTIGEN; GLUTAMINE; INTERLEUKIN 1BETA; LYSINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SYNTHETIC PEPTIDE; TYROSINE;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; GRAFT VERSUS HOST REACTION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MINOR HISTOCOMPATIBILITY COMPLEX; MIXED LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; BASE SEQUENCE; CHIMERA; DNA PRIMERS; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-1; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; MINOR HISTOCOMPATIBILITY ANTIGENS; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYMERS; PROTEIN BINDING; T-LYMPHOCYTES;

EID: 0029978508     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.10.5061     Document Type: Article

References (36)

1. den Haan, J. M., Sherman, N. E., Blokland, E., Huczko, E., Koning, F., Drijfhout, J. W., Skipper, J., Shabanowitz, J., Hunt, D. F., Engelhard, V. H. & Goulmy, E. (1995) Science 268, 1476-1480.
2. Sakamoto, H., Michaelson, J., Jones, W. K., Bhan, A. K., Abhyankar, S., Silverstein, M., Golan, D. E., Burakoff, S. J. & Ferrara, J. L. (1991) Proc. Natl. Acad. Sci. USA 88, 10890-10894.
3. Miconnet, I., Roger, T., Seman, M. & Bruley-Rosset, M. (1995) Eur. J. Immunol. 25, 364-368.
4. Griem, P., Wallny, H. J., Falk, K., Rötzschke, O., Arnold, B., Schönrich, G., Hämmerling, G. & Rammensee, H. G. (1991) Cell 65, 633-640.
5. Wang, W., Meadows, L. R., den Haan, J. M. M., Sherman, N. E., Chen, Y., Blokland, E., Shabanowitz, J., Agulnik, A. I., Hendrickson, R. C., Bishop, C. E., Hunt, D. F., Goulmy, E. & Engelhard, V. H. (1995) Science 269, 1588-1590.
6. Speiser, D. E., Zürcher, T., Ramseier, H., Hengartner, H., Staeheli, P., Haller, O. & Zinkernagel, R. M. (1990) Proc. Natl. Acad. Sci. USA 87, 2021-2025.
7. Wallny, P. J. & Rammensee, H. G. (1990) Nature (London) 343, 275-278.
8. Roopenian, D. C., Christianson, G. J., Davis, A. P., Zuberi, A. R. & Mobraaten, L. E. (1993) Immunogenetics 38, 131-140.
9. Rus, V., Svetic, A., Nguyen, P., Gause, W. C. & Via, C. S. (1995) J. Immunol. 155, 2396-2406.
10. Nestel, F. P., Price, K. S., Seemayer, T. A. & Lapp, W. S. (1992) J. Exp. Med. 175, 405-413.
11. Schlegel, P. G., Aharoni, R., Smilek, D. E., Fernandez, L. P., McDevitt, H. O., Tran, N., Vaysburd, M. & Chao, N. J. (1994) Blood 84, 2802-2810.
12. Blazar, B. R., Taylor, P. A. & Vallera, D. A. (1994) J. Immunol. 152, 3665-3674.
13. Schlegel, P. G., Vaysburd, M., Chen, Y., Butcher, E. C. & Chao, N. J. (1995) J. Immunol. 155, 3856-3865.
14. Ishioka, G. Y., Adorini, L., Guery, J. G., Gaeta, F. C. A., LaFond, R., Alexander, J., Powell, M. F., Sette, A. & Grey, H. M. (1994) J. Immunol. 152, 4310-4319.
15. Samson, M. F. & Smilek, D. E. (1995) J. Immunol. 155, 2737-2746.
16. Sela, M., Arnon, R. & Teitelbaum, D. (1990) Bull. Inst. Pasteur 88, 303-314.
17. Teitelbaum, D., Meshorer, A., Hirshfeld, T., Arnon, R. & Sela M. (1971) Eur. J. Immunol. 1, 242-248.
18. Teitelbaum, D., Webb, C., Meshorer, A., Arnon, R. & Sela, M. (1973) Eur. J. Immunol. 3, 273-279.
19. Bornstein, M. B., Miller, A., Slagle, S., Weitzman, M., Crystal, H., Drexler, E., Keilson, M., Merriam, A., Wassertheil-Smoller, S., Spada, V., Weiss, W., Arnon, R., Jacobsohn, I., Teitelbaum, D. & Sela, M. (1987) N. Engl. J. Med. 317, 408-414.
20. Johnson, K. P., Brooks, B. R., Cohen, J. A., Ford, C. C., Goldstein, J., Lisak, R. P., Myers, L. W., Panitch, H. S., Rose, J. W., Schiffer, R. B., Vollmer, T., Weiner, L. P. & Wolinsky, J. S. (1995) Neurology 45, 1268-1276.
21. Fridkis-Hareli, M., Teitelbaum, D., Gurevich, E., Pecht, I., Brautbar, C., Kwon, O. J., Brenner, T., Arnon, R. & Sela, M. (1994) Proc. Natl. Acad. Sci. USA 91, 4872-4876.
22. Teitelbaum, D., Aharoni, R., Arnon, R. & Sela, M. (1988) Proc. Natl. Acad. Sci. USA 85, 9724-9728.
23. Teitelbaum, D., Fridkis-Hareli, M., Arnon, R. & Sela, M. (1996) J. Neuroimmunol., in press.
24. Fridkis-Hareli, M., Teitelbaum, D., Arnon, R. & Sela, M. (1995) Cell. Immunol. 168, 229-236.
25. Claman, H. N., Jaffee, B. D., Huff, J. C. & Clark, R. A. (1985) Cell. Immunol. 94, 73-84.
26. Korngold, R. & Sprent, J. (1987) J. Exp. Med. 165, 1552-1564.
27. Hamilton, B. L. (1987) J. Immunol. 139, 2511-2555.
28. Webb, S., Morris, C. & Sprent, J. (1990) Cell 63, 1249-1256.
29. Sellins, K. S. & Cohen, J. J. (1987) J. Immunol. 139, 3199-3206.
30. McConkey, D. J., Hartzeli, P., Duddy, S. K., Håkansson, H. & Orrenius, S. (1988) Science 242, 256-259.
31. Newell, M. K., VanderWall, J., Beard, K. S. & Freed, J. H. (1993) Proc. Natl. Acad. Sci. USA 90, 10459-10463.
32. Chao, N. J. (1992) Curr. Opin. Immunol. 4, 571-576.
33. Hunt, D. F., Michel, H., Dickinson, T. A., Shabanowitz, J., Cox, A. L., Sakaguchi, K., Appella, E., Grey, H. M. & Sette, A. (1992) Science 256, 1817-1820.
34. Teitelbaum, D., Aharoni, R., Sela, M. & Arnon, R. (1991) Proc. Natl. Acad. Sci. USA 88, 9528-9532.
35. Webb, C., Teitelbaum, D., Arnon, R. & Sela, M. (1973) Eur. J. Immunol. 3, 279-286.
36. Aharoni, R., Teitelbaum, D. & Arnon, R. (1993) Eur. J. Immunol. 23, 17-25.