메뉴 건너뛰기




Volumn 56, Issue 6, 2001, Pages 702-708

Mechanisms of action of glatiramer acetate in multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GLATIRAMER; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

EID: 0035957307     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.56.6.702     Document Type: Review
Times cited : (243)

References (86)
  • 1
    • 0029114427 scopus 로고
    • Copolymer 1: A most reasonable alternative therapy for early relapsing-remitting multiple sclerosis with mild disability
    • (1995) Neurology , vol.45 , pp. 1245-1247
    • Wolinsky, J.S.1
  • 2
    • 0033600078 scopus 로고    scopus 로고
    • Progress in determining the causes and treatment of multiple sclerosis
    • (1999) Nature , vol.399 , Issue.SUPPL.
    • Noseworthy, J.H.1
  • 3
    • 0032893142 scopus 로고    scopus 로고
    • Glatiramer acetate or interferon-β for multiple sclerosis? A guide to drug choice
    • (1999) CNS Drugs , vol.11 , pp. 289-306
    • Milo, R.1    Panitch, H.2
  • 4
    • 0001925434 scopus 로고    scopus 로고
    • Glatiramer acetate
    • Hawkins CP, Wolinsky JS, eds. Principles of treatments in multiple sclerosis. Oxford, Woburn: Butterworth-Heinemann
    • (2000) , pp. 71-94
    • Wolinsky, J.S.1
  • 5
    • 0029936443 scopus 로고    scopus 로고
    • New insights into the mechanism of action of copolymer 1 in experimental allergic encephalomyelitis and multiple sclerosis
    • (1996) J Neurol , vol.243 , Issue.SUPPL. 1
    • Arnon, R.1    Sela, M.2    Teitelbaum, D.3
  • 6
    • 0030013545 scopus 로고    scopus 로고
    • The development of Cop-1 (Copaxone®), an innovative drug for the treatment of multiple sclerosis: Personal reflections
    • (1996) Immunol Lett , vol.50 , pp. 1-15
    • Arnon, R.1
  • 13
    • 0029986881 scopus 로고    scopus 로고
    • The autoimmune reactivity to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis is potentially pathogenic: Effect of copolymer 1 on MOG-induced disease
    • (1996) J Neurol , vol.243 , Issue.SUPPL. 1
    • Ben-Nun, A.1    Mendel, I.2    Bakimer, R.3
  • 14
    • 0029978508 scopus 로고    scopus 로고
    • A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5061-5066
    • Schlegel, P.G.1    Aharoni, R.2    Chen, Y.3
  • 20
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis. Results of a phase III multicenter, double-blind, placebo-controlled trial
    • (1995) Neurology , vol.45 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 21
    • 6844254570 scopus 로고    scopus 로고
    • Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability
    • (1998) Neurology , vol.50 , pp. 701-708
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 22
    • 0000093080 scopus 로고    scopus 로고
    • The effect of glatiramer acetate (Copaxone®) on disease activity as measured by cerebral MRI in patients with relapsing-remitting multiple sclerosis (RRMS): A multi-center, randomized, double blind, placebo-controlled study extended by open-label treatment
    • Abstract
    • (1999) Neurology , vol.52 , Issue.SUPPL. 2
    • Comi, G.1    Filippi, M.2
  • 25
    • 0032111406 scopus 로고    scopus 로고
    • Probing into the realm of proteins and immunity
    • (1998) Protein Sci , vol.7 , pp. 1653-1659
    • Sela, M.1
  • 26
    • 0015888233 scopus 로고
    • In vivo and in vitro immunological cross-reactions between basic encephalitogen and synthetic basic polypeptides capable of suppressing experimental allergic encephalomyelitis
    • (1973) Eur J Immunol , vol.3 , pp. 279-286
    • Webb, C.1    Teitelbaum, D.2    Arnon, R.3    Sela, M.4
  • 33
    • 0027397577 scopus 로고
    • T suppressor hybridomas and interleukin-2 dependent lines induced by copolymer 1 or by spinal cord homogenate down-regulate experimental allergic encephalomyelitis
    • (1993) Eur J Immunol , vol.23 , pp. 17-25
    • Aharoni, R.1    Teitelbaum, D.2    Arnon, R.3
  • 39
    • 0033103608 scopus 로고    scopus 로고
    • Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor (BDNF) in vitro and in brain lesions: A neuroprotective role of inflammation?
    • (1999) J Exp Med , vol.189 , pp. 865-870
    • Kerschensteiner, M.1    Gallmeier, E.2    Behrens, L.3
  • 45
    • 0000316952 scopus 로고    scopus 로고
    • The lymphocyte proliferative response to glatiramer acetate in normal humans is dependent on both major histocompatibility complex (MHC)
    • Abstract
    • (2000) J Neurol , vol.247 , Issue.SUPPL. 3
    • Ragheb, S.1    Lisak, R.P.2
  • 47
    • 0005628335 scopus 로고    scopus 로고
    • Effect of treatment of patients with glatiramer acetate (copolymer-1) on the proliferative response of peripheral blood mononuclear cells to glatiramer acetate in vitro
    • Abstract
    • (1999) Ann Neurol , vol.46 , pp. 457
    • Ragheb, S.1    Abramczk, S.2    Lisak, R.P.3
  • 56
    • 0343006716 scopus 로고    scopus 로고
    • Glatiramer acetate (Copolymer-1)-specific, human T cell lines: Cytokine profile and suppression of T cell lines reactive against myelin basic protein (MBP)
    • (2000) Neurosci Lett , vol.289 , pp. 205-208
    • Dabbert, D.1    Rösner, S.2    Krämer, M.3
  • 65
    • 0034678450 scopus 로고    scopus 로고
    • Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex
    • (2000) J Exp Med , vol.191 , pp. 1395-1412
    • Krogsgaard, M.1    Wucherpfennig, K.W.2    Canella, B.3
  • 66
    • 0033152935 scopus 로고    scopus 로고
    • Clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors
    • (1999) J Immunol , vol.162 , pp. 6303-6306
    • Besser, M.1    Wank, R.2
  • 67
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • (1997) Immunol Today , vol.19 , pp. 335-343
    • Weiner, H.L.1
  • 68
    • 0030989875 scopus 로고    scopus 로고
    • Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives
    • (1997) Brain , vol.120 , pp. 865-916
    • Hohlfeld, R.1
  • 69
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 77
    • 0028842529 scopus 로고
    • Interferon (IFN) β acts downstream of IFN-γ-induced class II transactivator messenger RNA accumulation to block histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-γ
    • (1995) J Exp Med , vol.182 , pp. 1517-1525
    • Lu, H.T.1    Riley, J.L.2    Babcock, G.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.