Vaccinia virus complement control protein is capable of protecting xenoendothelial cells from antibody binding and killing by human complement and cytotoxic cells

Transplantation

Volumn 71, Issue 6, 2001, Pages 796-801

  Al Mohanna, Futwan ^a,b   Parhar, Ranjit ^a,b   Kotwal, Girish J ^a,b,c  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^b University of Louisville School of Medicine   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; FLUORESCEIN ISOTHIOCYANATE; UNCLASSIFIED DRUG; VACCINIA VIRUS COMPLEMENT CONTROL PROTEIN;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING SITE; CELL DEATH; CELL PROTECTION; CYTOTOXIC T LYMPHOCYTE; ENDOTHELIUM CELL; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0035957188     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200103270-00019     Document Type: Article

References (18)

1. Interactions of microorganisms with the immune system
2. Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins
3. Vaccinia virus major secretory protein inhibits the classical complement cascade
4. Regulation of complement activity by vaccinia virus complement-control protein
5. Vaccinia virus complement-control protein prevents antibody-dependent complement-enhanced neutralization of infectivity and contributes to virulence
6. The cowpox virus- encoded homolog of the vaccinia virus complement control protein is an inflammation modulatory protein
7. The inflammation modulatory protein of cowpox virus drasticaly dimishes the tissue damage by down-regulating infiltration of lymphocytes
8. The genomic sequence analysis of the left species-specific region of cowpox virus reveals a cluster of ORFs for immunomodulatory proteins and host range functions
9. Molecular mimicry of the inflammation modulatory proteins (IMPs) of poxviruses: Evasion of the inflammatory response to preserve viral habitat
10. Surface exposed conserved K/R-X-K/R sites and net positive charge on poxviral complement control proteins contribute to heparin binding and to inhibition of molecular interactions with human endothelial cells: Novel mechanism for evasion of host defense
11. Vaccinia virus complement control protein is a virokine with lysozyme-like heparin binding activity: Possible implications in prolonged evasion of host immune response
12. Cellular transplantation
13. Pro-inflammatory complement activation by the Abeta peptide of Alzheimer's disease is biologically significant and can be blocked by vaccinia virus complement control protein
14. Purification of virokines by ultrafiltration
15. Naive neutrophils and xenotransplantation
16. Activation of naïve xenogeneic but not allogeneic endothelial cells by human naive neutrophils: A potential occult barrier to xenotransplantation
17. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria
18. Heparin- binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis